Review Flashcards
conjunctival xerosis in VAD caused by ->
deficiency of mucin produced by goblet cells (degeneration of goblet cells)
Can cause hydration of the cornea
Hypotony -> reduced compressive force
Maps seen in epithelial basement membrane dystrophy show this staining
NEGATIVE staining
Dellen staining
positive or pooling of dye
Effect of tetracycline on anticoagulants
potentiate anticoagulant effect
Treatment options for ocular rosacea
Tetracycline (SE no anticoagulant)
Azithromycin (no cardio problems - may cause irregular heart rhythm)
Erythromycin - low adverse reactions
Diffuse punctate staining + whorled epithelium with normal schirmer/TBUT
Toxic keratitis -> switch to PF alternatives
Extra row of eyelashes from ducts of meibomian glands
Distichiasis (congenital AD or acquired)
Cornea >13mm diagnosis and associated problem during surgery
megalocornea -> zonular instability
Type of eye a/w increased risk for choroidal effusion during cataract surgery
nanophthalmia
Condition most commonly a/w posterior embryotoxon
Normal eyes
Corneal finding in children with untreated congenital syphilis
interstitial keratitis develops 6 to 12 yo with progressive corneal edema, ABNORMAL DEEP STROMAL VASCULARIZATION adjacent to descemet membrane
Medication that causes chalky white deposits that adhere to corneal epithelial defects
topical fluoroquinolone especially ciprofloxacin
Band keratopathy made of what substance?
Workup labs for unexplained band keratopathy should include
calcium hydroxyapatite
Calcium and phosphate tests -> elevated phosphate can drive precipitation of calcium hydroxyapatite (renal patient)
Vision loss in terrier marginal degeneration
high against-the-rule, oblique or irregular ASTIGMATISM
Monitor patient with cystinosis for –>
Tx for cystinosis –>
Nephropathy -may lead to kidney failure by 10 years of age
Topical cysteamine for cornea
Oral cysteamine for posterior segment (retinopathy, optic neuropathy)
History you must elicit for keratinized epithelium, cellular debris, corynebacterium xerosis
restrictive diet
alcoholism
chronic lipid malabsorption (bowel resection, cystic fibrosis)
Surrounded by capsid of primarily glycoproteins more resistant to alcohol
Adenoviruses -> diluted bleach
Varicella-zoster vaccine reduces the incidence of zoster by –>
50% in new cases of zoster and 66% postherpetic neuralgia
Immunity lasts only 5 years
follicular conjunctivitis with eyelid nodule with central umbilication would show this pathology
eosinophilic intracytoplasmic inclusions (Henderson-Patterson bodies) within epidermal cells surrounding a necrotic core
Pathology of herpetic vesicle
Vacuolized cytoplasm with multinucleate cells
Foamy histiocytes surrounding blood vessels
xanthelasma
treatment for gram-negative intracellular diplococci
intramuscular ceftriaxone 1 g for gonococcal conjunctivitis caused by neisseria gonorrhoeae
bandlike or stellate tarsal scarring superior + corneal scarring, trichiasis
Trachoma caused by bacterium Chlamydia trachomatis (Serotypes A-C)
Tx for fungal keratitis due to infection with filamentous fungi
Fusarium –> Natamycin
Dense white-blood-cell reaction following length of corneal nerve
Radial perineuritis
MARKING “L” cornea
M: Multiple Endocrine Neoplasia
medullary carcinoma of the thyroid
Pheochromocytoma
Mucosal neuromas
A: Acanthamoeba R: Refsum's disease (phytanic acid/Riley Day) K: Keratoconus I: Icthyosis N: Neurofibromatosis G: Grafts (failed) Glaucoma (infantile) L: Leprosy
Cause contact dermatoblepharitis
topical medication
Type IV delayed hypersensitivity reaction begin 24-72 hours following instillation of topical agent
Tx for chronic atopic dermatitis or atopic keratoconjunctivitis
Oral and topical T-cell inhibitors - Tacrolimus
Tx for surface squamous neoplasia
interferon-alpha2b 1 million IU/mL given 4 times daily until resolution (2 to 4 months)
Tx for 360 degree conjunctivalization of cornea after unilateral chemical burn
Simple gimbal epithelial transplantation (SLET)
Management when uveal prolapse occurs during acute open-globe repair
reposit tissue
Dieffenbachia cause keratoconjunctivitis by
calcium oxalate deposition
Cornea donors younger than 2 years old not used because
extremely steep and flaccid
Leads to myopic shift after cataract surgery with BCVA 20/20
anterior capsular contraction syndrome/lens phimosis
Rate of cataract surgery in developed country
10,000 per million population per year
Human lens changes with age
increasingly curved, more refractive power. Increase in water-insoluble proteins.
How is metabolic waste removed from the lens
aqueous humor
Protect the corneal endothelium with this agent in patient with corneal guttae
DISPERSIVE ophthalmic viscosurgical device (OVD)
Cohesive agent would be easily expelled during phaco
Helmholtz theory of accomodation
most of change in lens shape occurs at central anterior surface of the lens
What change occurs in the lens in the presence of high levels of glucose
Sorbitol pathway activated
Aldose reductase is key enzyme in this pathway
Hexokinase reaction is the rate-limiting step in glucose phosphorylation
Terminal differentiation
elongation of lens epithelial cells into lens fibers
Sx of cortical cataracts
glare
histology of PSC
posterior migration of lens epithelial cells and enlargement
Lamellar membrane whorls seen on EM for this cataract
nuclear cataract
Cataract a/w chalcosis
“sunflower” cataract
Cataract in galactosemia
“oil droplet”
Determining AL with immersion technique or contact application most useful in this setting
Dense vitreous hemorrhage
Corneal scarring
PSC
Biometry still possible with silicone oil or aphakia - need adjustment
Protect the corneal endothelium with this agent in patient with corneal guttae
DISPERSIVE ophthalmic viscosurgical device (OVD)
Cohesive agent would be easily expelled during phaco
Tx for shallow anterior chamber 2/2 ciliary block
aqueous suppressants + cycloplegia
IOL most likely to cause negative dysphotopsia
smaller, square-edge optic designs
Equivalent in blood of tissue-bound mast cells
Basophils
When they leave bloodstream and go to tissue they become mast cells
May present as peripheral necrotizing retinochoroiditis resembling acute ARN
Treponema pallidum Syphilis
Risk factor in patient with WNV-associated uveitis increased risk of WNV mortality
DM
Coin-shaped lesions circinate stellate KP
CMV anteiror uveitis
HSV1/HSV2 Corneal finding
Diffuse stellate KP
+/- granulomatous or non-granulomatous KP
Candidemia with decreased vision exam creamy yellowish chorioretinal lesions in posterior pole. Tx?
Oral voriconazole
excellent penetration, no vitreous involvement
m/c ocular manifestation of coccidiodomycosis
phlyctenular granulomatous conjunctivitis
Percentage chance that PVRL willl develop intracranial disease
60-75%
Primary vitreoretinal lymphoma (PVRL) is a subset of primary central nervous system lymphoma (PCNSL)
Band keratopathy histology
deposition of calcium hydroxyapatite at level of bowman membrane
Virus a/w PCNSL and PVRL
Epstein-Barr HHV-4
Immune response to parasitic infections
Th2-mediated response
Immune response in acute anterior uveitis, giant papillary conjunctivitis and VKH
Th1-mediated response
antigenic site on antibodies
idiotopes
antigenic sites on foreign molecules
epitopes
Controls the immunoregulatory processes of the retina and choroid
reitnal pigment epithelium (RPE)
Modulate T-cell activity and convert effector cells into regulatory cells
Population who are positive for HLA-B27 and those with Acute Anteiror Uveitis (AAU)
8% HLA-B27
0.012% develop AAU (1 in 667)
HLA-DR4
VKH, SO
Tumor necrosis factor alpha inhibitors and side effects
Adalimumab Infliximab Certolizumab Golimumab Etanercept
CNS demyelination
Lymphoma
HBV reactivitation
Therapy that may induce antichimeric antibodies
Infliximab - 75% receiving 3+ infusions developed antinuclear antibodies - drug-indused lupus syndrome
Treatment for recurrent noninfectious refractory anterior scleritis
systemic steroids
prednisone 1 mg/kg/day
Scleritis you must r/o infectious etiology
NODULAR anterior scleritis especially if necrosis
Tx for TINU
responsive to high-dose oral corticosteroids
Ankylosing spondylitis 90% HLA-B27 - systemic concern
Pulmonary apical fibrosis –> CXR
Aortic valvular insufficiency –> Cardiac echogram
Initial scleritis followed by chronic headaches, tracheomalacia, focal segmental glomerulonephritis BRAO or BRVO or CRAO/CRVO
Granulomatosis with polyangiitis - necrotizing granulomatous vasculitis of upper and lower respiratory tract
Urinalysis (85%) with glomerulonephritis
Anti-cyclic citrullinated antibody test
anti-CCP antibody dianosis of RA with high specificity
Sarcoid, Behcet and VKH can show involvement of this system
CNS
NOT in MFC + panuveitis
White dot syndrome or chorioretinopathy a/w infectious etiology
serpiginous choroiditis or geographic/helicoid choroidopathy –> Mycobacterium tuberculosis
Testing preliterate children what optotype has best calibration and reliability
HOTV and LEA symbols
Type of deviation in infantile esotropia
comitant deviation -does not vary by more than a few prism diopters in different positions of gaze or with either eye
lateral muscular branch supplies
LR, SR, SO, LPS
medial muscular branch
IR, MR, IO
EOM orbital layer vs global layer
orbital layer –> inserts on muscle pulley
global layer –>tendon inserts on sclera to move globe
agonist –>
synergist –>
antagonist –>
agonist - primary muscle moving the eye in a direction
synergist - muscle of same eye accts with agonist to produce same movement
antagonist - muscle in same eye as agonist that actis in direction opposite to that of agonist
EOM that has only a primary action and no secondary or tertiary action
medial and lateral rectus muscles
in complete third nerve palsy, what action of superior oblique muscle exacerbates abducted position in paretic eye
TERTIARY - abduction