reversals Flashcards
Naloxone reverses _____
- Reliably antagonizes respiratory depression produced by most opioids
1. Butorphanol
2. Buprenorphine (need higher doses because of buprenorphines strong affinity for mu receptor)
3. Fentanyl
4. Morphine
5. Hydromorphone
6. Methadone
Flumazenil reverses _____
- Midazolam
- Diazepam
- Rapid acting after IV administration
- Do NOT reverse in pts predisposed to seizures
Butorphanol can partially reverse ______
- narcosis produced by pure mu agonists (fentanyl, hydromorphone, morphine, methadone)
Edrophonium reverses ____
- non-depolarizing muscle relaxants (anticholinesterase inhibitor) - Atracurium
Neostigmine reverses ______
- competitive, nondepolarizing neuromuscular blocking agents like atracurium
Neostigmine reverses ______
- competitive, nondepolarizing neuromuscular blocking agents like atracurium
Yohimbine reverses _____
- xylazine
- detomidine
- Antagonizes alpha-2 agonist effects (useful for reversing excessive sedation
from high doses of xylazine or detomidine).
- It is not a specific alpha-2 antagonist, has a slow onset of action, and does
not reliably antagonize alpha-2 agonist
What would you use to reverse diazepam?
- Flumazenil
What would you use to reverse fentanyl?
- Naloxone
2. Butorphanol (partially reverse)
What would you use to reverse dexmedetomidine?
- Atipamezole
What would you use to reverse xylazine?
- Yohimbine
2. Atipamezole (very effective)
What would you use to reverse atracurium?
- Edrophonium
2. Neostigmine
What would you use to reverse midazolam?
- Flumazenil
What would you use to reverse methadone?
- Naloxone
2. Butorphanol (partially reverse)
What would you use to reverse detomidine?
- Yohimbine
2. Atipamezole (very effective)
What would you use to reverse hydromorphone?
- Naloxone
2. Butorphanol (partially reverse)
What would you use to reverse butorphanol?
- Naloxone
