Reversal Agents Flashcards
What is the drug class of atropine?
Tertiary amine anticholinergic
What is the mg/cc for atropine?
0.4 mg/cc
What is the dosing for atropine?
Peds: 15-70 μg/kg
Adults: 0.8-1.2 mg with neostigimine
What is the onset, peak, and duration of atropine?
Onset: 15-30 seconds
Peak: 2 minutes
Duration: 1-2 hours
What is the drug class of robinul (glycopyrrolate)?
Quatenary ammonium anticholinergic
What is the mg/cc for robinul (glycopyrrolate)?
0.2 mg/cc
What is the dose for robinul (glycopyrrolate)?
10-20μg/kg
What is the onset, peak, and duration of glycopyrrolate?
Onset: 1 minute
Peak: 5 minutes
Duration: 2-4 hours
What is the drug class of Narcan?
Opiod antagonist
What is the mg/cc for Narcan?
0.4mg/cc
What is the dosing for Narcan?
1-10 mcg/kg, repeat as required
What is the onset, peak, and duration of narcan?
Onset: 1-2 minutes
Peak: 5-15 minutes
Duration: 1-4 hours
What is the drug class of neostigmine (prostigmine)?
Carbamyl ester anticholinesterase
What is the mg/cc for neostigmine (prostigmine)?
0.5 or 1 mg/cc
What is the dosing for neostigmine?
25-75 mcg/kg
What is the onset, peak, and duration of neostigmine?
Onset: 1-3 minutes
Peak: 5-7 minutes
Duration: 40-60 minutes
What is the drug class for flumazenil (romazicon)?
Benzodiazepine antagonist
What is the mg/cc for flumazenil (romazicon)?
1 mg/cc
What is the dosing for flumazenil?
8-15μg/kg, 0.2mg typical adult dose increments,
up to 1
What is the onset, peak, and duration of flumazenil?
Onset: 1-2 minutes
Peak: 6-10 minutes
Duration: 30-60 minutes
What is the drug class of bridion (sugammadex)?
Cyclodextrin selective relaxant binding agent
What is the mg/cc of sugammadex?
100 mg/ml
What is the dosing of sugammadex?
2-16 mg/kg
What is the onset, peak, and duration of suggamadex?
Onset: 15-30 seconds
Peak: 1-2 minutes
Duration: 2 hours
