Reversal Agents Flashcards

1
Q

What is the drug class of atropine?

A

Tertiary amine anticholinergic

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2
Q

What is the mg/cc for atropine?

A

0.4 mg/cc

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3
Q

What is the dosing for atropine?

A

Peds: 15-70 μg/kg
Adults: 0.8-1.2 mg with neostigimine

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4
Q

What is the onset, peak, and duration of atropine?

A

Onset: 15-30 seconds
Peak: 2 minutes
Duration: 1-2 hours

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5
Q

What is the drug class of robinul (glycopyrrolate)?

A

Quatenary ammonium anticholinergic

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6
Q

What is the mg/cc for robinul (glycopyrrolate)?

A

0.2 mg/cc

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7
Q

What is the dose for robinul (glycopyrrolate)?

A

10-20μg/kg

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8
Q

What is the onset, peak, and duration of glycopyrrolate?

A

Onset: 1 minute
Peak: 5 minutes
Duration: 2-4 hours

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9
Q

What is the drug class of Narcan?

A

Opiod antagonist

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10
Q

What is the mg/cc for Narcan?

A

0.4mg/cc

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11
Q

What is the dosing for Narcan?

A

1-10 mcg/kg, repeat as required

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12
Q

What is the onset, peak, and duration of narcan?

A

Onset: 1-2 minutes
Peak: 5-15 minutes
Duration: 1-4 hours

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13
Q

What is the drug class of neostigmine (prostigmine)?

A

Carbamyl ester anticholinesterase

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14
Q

What is the mg/cc for neostigmine (prostigmine)?

A

0.5 or 1 mg/cc

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15
Q

What is the dosing for neostigmine?

A

25-75 mcg/kg

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16
Q

What is the onset, peak, and duration of neostigmine?

A

Onset: 1-3 minutes
Peak: 5-7 minutes
Duration: 40-60 minutes

17
Q

What is the drug class for flumazenil (romazicon)?

A

Benzodiazepine antagonist

18
Q

What is the mg/cc for flumazenil (romazicon)?

A

1 mg/cc

19
Q

What is the dosing for flumazenil?

A

8-15μg/kg, 0.2mg typical adult dose increments,

up to 1

20
Q

What is the onset, peak, and duration of flumazenil?

A

Onset: 1-2 minutes
Peak: 6-10 minutes
Duration: 30-60 minutes

21
Q

What is the drug class of bridion (sugammadex)?

A

Cyclodextrin selective relaxant binding agent

22
Q

What is the mg/cc of sugammadex?

A

100 mg/ml

23
Q

What is the dosing of sugammadex?

A

2-16 mg/kg

24
Q

What is the onset, peak, and duration of suggamadex?

A

Onset: 15-30 seconds
Peak: 1-2 minutes
Duration: 2 hours