Retina

Question 1

Characteristics of Aflibercept?

Answer 1

Recombinant fusion protein. It acts as a soluble decoy receptor that binds to VEGF-A (vascular endothelial growth factor-A) and PlGF (placental growth factor).

Question 2

What are the main characteristics of angiomatous proliferation (RAP)?

Answer 2

Neovascularisation originates in the retina, close to the outer plexiform layer. It tends to progress towards the subretinal space and continues across the RPE, growing into the sub-RPE space. Initially, it respects the peripapillary location and the foveal avascular zone. In more than 50% of cases, characteristic retinal-retinal anastomosis can be observed. It is estimated that it becomes bilateral in almost 100% of patients. It is commonly associated with thin choroids.

Question 3

Appearance of drusen in fluorescein angiography?

Answer 3

They appear hypofluorescent

Question 4

Categorize drusen by size

Answer 4

small (<63 μm), intermediate (63–124 μm), and large (>125 μm).