reticular formations Flashcards
where can the reticular formations be found
in brainstem tegmentum
what are reticular formations
mass of neurons and nerve fibers extending from caudal medulla to rostral midbrain
what do reticular formations receives
receives input from most sensory systems
what do reticular formations send
sends efferent fibers to all CNS levels
what to reticular formations influence
skeletal muscle activity, somatic and visceral sensation, ANS and endocrine systems as well as level of consciousness
the reticular formations are deeply placed in ______
continuous network of nerve cells and fibers extending from brainstem, subthalamus, hypothalamus and thalamus
what are the 3 longitudinal columns
Median column - at median plane: intermediate-sized neurons
Medial column - large neurons
Lateral column - small neurons
what does the raphe nuclei of medulla receive
inputs from spinal cord, trigeminal sensory nuclei and periaqueductal gray matter of the midbrain
where does the raphe nuclei of medulla project
to cerebellum, dorsal horn of spinal cord and trigeminal nuclei
exp the analgesic effect of electrical stimulation of the midbrain periaqueductal gray
from facilitatory input from the periaqueductal gray matter to medullary raphe nuclei and its inhibitory projections on spinothalamic neurons in dorsal horn of spinal cord
what does the raphe nuclei of pons and midbrain receive
inputs from prefrontal cortex, limbic system and hypothalamus
where does the raphe nuclei of pons and midbrain project
to forebrain, cerebellum and brainstem
involved in pain mechanisms
Caudal raphe nuclei
involved with wakefulness, alertness and sleep
Rostral raphe nuclei
the paramedian groups receives and projects to ______
input from spinal cord, cerebral cortex, vestibular nuclei
project to cerebellum
the medial group receives input from
spinal cord, ascending sensory systems, superior colliculus, vestibulocerebellum, hypothalamus and cerebral cortex
the descending projections of the medial group project to ______ and controls ______
SC and motor control
the ascending projections of the medial group project to ______ and controls ______
intralaminar nuclei of the thalamus and basal cholinergic nuclei (nucleus basalis of Meynert)
consciousness and alertness
nucleus reticularis pontis caudalis is responsible for ______
paradoxical (REM) sleep
lateral group recieves _______
Receive input from contralateral red nucleus, spinal cord, trigeminal, auditory and vestibular sensory systems
lateral group projects to _______
Project to both cerebellar hemispheres and to medial nuclei
Pedunculopontine nucleus recieves _____ and is responsible for _________
input from cerebral cortex, globus pallidus interna and substantia nigra pars reticulata
Locomotion center
parabrachial nucleus recieves _____ and projects _________
input from amygdala, nucleus solitarius
Projects to hypothalamus, preoptic
area, amygdala and intralaminar
thalamic nuclei
parabrachial nucleus is responsible for _______
Autonomic regulation
Continuation of reticular formation from brainstem
Reticular Nucleus of Thalamus
reticular nuc of thalamus receives and projects ______
input from cerebral cortex and other thalamic nuclei
Project to other thalamic nuclei
NT for reticular nuc of thalamus
GABA - inhibitort
function of reticular nuc of thalamus
Integrating and gating thalamic nuclei activities
where does acetylcholine project to
Pontomesencephalic region of brainstem - pedunculopontine tegmental nuclei and laterodorsal tegmental nuclei
Basal forebrain
deficiency in Acethylcholine
Alzheimer’s
dopamine is located where
Substantia nigra pars compacta
Ventral tegmental area
Mesostriatal (nigrostriatal)
for movement
Mesolimbic
Overactivity hallucinations
Schizophrenia - kapag too much dopamine sa mesolimbic
Mesocortical
function. working memory, attentional aspects
Dysfunction: cognitive deficit and hypokinesia in PD (Parkinson’s disease)
Modulation of attention, sleep wake
states and mood
Norepinephrine (Noradrenaline)
Serotonin is found on
Raphe nuclei of brainstem
Serotonin is for
Sleep, emotion
Found in neurons of posterior hypothalamus in tuberomammillary nucleus
Histamine
Histamine
Maintain alert state
pacemaker for respiration
Pre-BÖtzinger complex
located along caudal lateral wall of the fourth ventricle in medulla
Area Postrema
Contains chemotactic trigger zone
Area Postrema
Maintain sphincter control
Pontine micturition center