Restrictive Lung Disease

Question 1

What drugs may cause drug-induced alveolitis?

Answer 1

• Amiodarone
• Bleomycin, Methotrexate
• Gold

Question 2

What causes outwith the lungs can cause restrictive lung disease?

Answer 2

Skeletal, muscle weakness, abdominal obesity

Question 3

Give examples of muscle weakness conditions that can cause restrictive lung disease.

Answer 3

Guillian Barre, Myaesthenia Gravis, Motor neurone

disease ,Poliomyelitis

Question 4

What is “dust disease” also known as?

Answer 4

Pneumoconiosis

Question 5

What types of fibrogenic dust disease are there?

Answer 5

Fibrogenic

•   Asbestosis
•   Silicosis

Question 6

What types of non fibrogenic dust disease are there?

Answer 6

Siderosis (Iron)

•   Stanosis (Tin)
•   Baritosis (Barium)

Question 7

What are examples of autoimmune alveolitis?

Answer 7

SLE,Polyarteritis,Wegeners,Churg-Strauss, Bechet’s

Question 8

How does alveolitis present?

Answer 8

-Breathless on exertion 
•  Cough but no wheeze 
•  Finger clubbing 
•  Inspiratory Lung crackles 
•  Central cyanosis (if hypoxaemic) 
•  Pulmonary fibrosis occurs as end stage response to 
chronic inflammation

Question 9

What happens to lung volumes in restrictive lung disease?

Answer 9

↓FEV1 ↓FVC normal ratio

Question 10

What is the peak flow like?

Answer 10

normal

Question 11

What are raised in sarcoidosis?

Answer 11

Serum ACE and Ca

Question 12

What is the 1st line of treatment?

Answer 12

Systemic Corticosteroids- ie oral prednisolone-inhaled

corticosteroids not effective

Question 13

What is the 2nd line of treatment?

Answer 13

oral Azathioprine , Cyclophosphamide, Mycophenolate

Cylcosporin