RESPONSE

Question 1

State the term for desensitization to drugs

Answer 1

Tachyphylaxis

Question 2

Tachyphylaxis - elaborate

Answer 2

rapidly diminishing response to successive doses of a drug rendering it less effective, normal drug response may be recovered with an increased dose. This is common with drugs acting on the nervous system.

Question 3

Desensitisation:

Tachyphylaxis: acute, sudden decrease in response to a drug after use- ….-term drug tolerance

….. the dose may …… response

Answer 3

short
increasing, restore

Question 4

GAP JUNCTIONS
Structure
FUNCTION
LOCATION - purpse in one of these locations 2 words

Answer 4

Gap junctions

Connexin subunits - 6 form a connexon, one connexon in each cell membrane

For passage of ions and small molecules

Includes passage of second messengers between adjacent cells

Epithelium

Cardiaccan create an electrical syncytium

Some smooth muscle cells

Question 5

Gap junctions:

2 ….. that form a channel, 1 in each ……, each made of …..

For the passage of …..(e.g. second messengers) between …… cells

For example, …. , ….. and …. cells- can create an …. ……

Answer 5

connexons
cell membrane
6 connexins
small ions and molecules
adjacent
epithelial cells, smooth muscle cells, cardiac cells
electrical syncytium