Respo module - leprosy

Question 1

dapsone adverse effect

Answer 1

Adverse effects includes hemolysis, especially in pt with G6PDH deficiency , methemoglobinemia , peripheral neuropath , erythema nodosum leprosum

Question 2

drug of choice for leprosy

Answer 2

dapsone , rifampin , clofazimine

Question 3

MOA of dapsone

Answer 3

inihibits folate synthesis via dihydropteroate synthetase inhibition

Question 4

dapsone is

Answer 4

bacteriostatic

Question 5

dapsone can be also given in

Answer 5

give in treatment of pneumonia ( pneumoncystis jiroveci) in pt with HIV .

Question 6

dapsone adverse effect

Answer 6

Adverse effects includes hemolysis, especially in pt with G6PDH deficiency , methemoglobinemia , peripheral neuropath , erythema nodosum leprosum.

Question 7

dapsone undergoes

Answer 7

enters enterohepatic circulation and undergoes hepatic acetylation .

Question 8

clofazimine MOA

Answer 8

Binds to DNA and prevents it from serving as template DNA for future replication.

Question 9

clofazimine is

Answer 9

bactericidal

Question 10

ROA of drug? property? penetrate CNS?

Answer 10

oral intake, doesn’t cross CNS , anti- inflammatory activity

Question 11

adverse effect of clofazimine

Answer 11

adverse effect ; eosinophillic eneteritis , red brown discoloration of skin.