Respirology Flashcards
Name the 2 criteria needed for a diagnosis of asthma
- History of Variable respiratory symptoms that vary over time and intensity
- Confirmed Variable expiratory airflow limitation
- Need spirometry for diagnosis
Name 4 clinical phenotypes of asthma
- Allergic: Classic asthma, atopy, eosinophilic inflammation, responds to ICS
- Non-allergic: Neutrophilic, eosinophilic or paucigranulocytic inflammation with less response to. ICS
- Adult-onset: Non-allergic, requires higher ICS doses, rule-out occupational asthma
- Asthma associated with obesity: little eosinophilic inflammation
- Associated with persistent airflow limitation: Longstanding asthma causing fixed obstrucion due to airway remodelling
How is asthma diagnosed
- On PFT. Require presence of 2 criteria
- Expiratory airflow limitation
- Reduced FEV1/FVC confirmed at least once
- Variability, demonstrated by presence of at least one of the following:
- Positive bronchodilator reversibility
- Improvement in FEV1 by >12% and 200ml post bronchodilator
- Improvement in lung function with antiinflammatory treatments x4 weeks
- Improvement in FEV1>12% and 200ml
- Peak flow variability
- Average daily diurnal PEF variability >10%
- Excessive variability in twice daily PEF over 2 weeks
- Positive bronchial challenge test or exercise challenge test
- Positive bronchodilator reversibility
- Expiratory airflow limitation
What are the criteria for a positive, borderline and negative methacholine challenge
- Look for drop in FEV1 by 20% while giving increasing doses of metacholine. The dose required is your PC20
- PC20 < 4 mg/ml = positive
- PC20 4-16 = borderline
- PC20 > 16 = negative
What criteria makes an exercise challenge positive for asthma
Fall in FEV1 of > 10% and 200ml from baseline
List the CTS asthma control criteria

List risk factors for severe asthma exacerbation
- Any history of a previous severe asthma exacerbation
- poorly controlled asthma as per CTS criteria
- Current smoker
- Overuse of SABA (= use of more than 2 saba inhalers per year)
What defines a severe asthma exacerbation
- Any one of
- Requires systemic steroids
- Requires ED visit
- Requires hospital admission
Describe the stepwise approach to asthma as per the GINA guidelines

Describe the non-pharmacological treatments for asthma
- confirm the diagnosis, education and written asthma action plan
- Weight loss, exercise training
- Allergen/trigger avoidance. allergen immunotherapy
- Smoking cessation
- vaccination
- Avoidance of NSAIDS +/- Beta-blockers
- Treat comorbidities
What should be assessed before stepping up asthma therapy
- Inhaler technique and adherence
- optimisation of non-pharmacological management
When can you consider stepping down asthma therapy
If patient has symptom control for 2 months and is low risk for exacerbations
When should LTRA be considered in asthma
Less effective than inhalers
May be appropriate as initial controller therapy in patients who are intolerant or unwilling to use ICS
Most effective in aspirin induced asthma, exercise induced asthma or allergic rhinitis
LABA-ICS > ICS-LTRA
What black box warning is associated with Montelukast
Increased suicidality in adolescents and adults
What is the difference between uncontrolled and severe asthma

What workup should be sent in severe asthma
- Total IgE
- Peripheral eosinophil count
- Sputum eosinophils and FeNO when available
What classes of medications can be considered in severe asthma
- Tiotropium mist inhaler
- Macrolides
- Biologics
- Low dose oral corticosteroids
- ?Bronchial thermoplasty in specialized centers
- Role remains uncleat
What is Omalizumab and what are the indications for it’s use?
Anti-IgE
- Indication
- Allergic asthma with IgE 30-700 sensitive to at least 1 perennial allergen, severe despite high doses ACS and one other controller
What are mepolizumab, resilizumab and benralizumab and what are their indications
Anti IL-5
- Indications
- Severe eosinophilic asthma (Eos >300) and recurrent exacerbations despite high dose ICS and another controller
What is dupilumab and what are it’s indications?
Anti IL-4 and IL-13
- Add-on option for severe eosinophilic asthma or those with nasal polyposis moderate-severe atopic dermatitis
How is seasonal allergic asthma treated
Start ICS immediately when symptoms commence and continue for 4 weeks after relevant pollen season ends
How is exercise-induced asthma treated
Salbutamol pre-exercise
if insufficient add LTRA pre-exercise
If still insufficient try regular ICS
What percent of patients with asthma will have worstening of their asthma symptoms during pregnancy
- Rule of thirds:
- 1/3 get better
- 1/3 stay the same
- 1/3 get worst
In which trimester of pregnancy are asthma exacerbations most common
second trimester










