respiratory system Flashcards
describe homeostatic functions of the lung. (4)
- gas exchange occurs…
- between atmosphere and blood to provide oxygen to tissues and remove CO2 generated in oxidative metabolisation
O2 + food =CO2 = HO2 +APT
- regulates body PH by
retaining or eliminating CO2
- controls blood pressure
through the conversion of angiotensin 1 to angiotensin 2
airflow occurs by
bulk flow
airflow occurs by
bulk flow i.e.
high pressure to low pressure
(1r to the 4th power)
F=(P1-P2)/R
lung connected to chest wall by
pleura
describe conducting zone (4)
- leads from outside body to inside lungs
- nasal cavity, pharynx, trachea, bronchus and bronchioles
- total volume 150ml
- anatomical dead space
respiratory zone
- gas exchange
- bronchioles, alveolar ducts, alveoli
- 3 litre volume
3 types of cells in lungs
TYPE 1- thin epithelial cells that line 90% of alveoli surface area. gas diffuses across these cells and into blood
TYPE 2- synthesise, secrete and metabolise alveolar surfactant, a lipid rich substance that prevents lungs from collapsing
ALVEOLAR MACRROPHAGES - the clean-up cells, attracted to infection, trauma or inhaled particles
PA
pressure in alveoli
Patm
atmospheric pressure
pressure in breathing
air flows into the mouth until PA=Patm
normal ventilation rate
10-18 breaths per min
ventilation rate controlled by
medulla oblongata
FRC
functional residual capacity
resting volume of lung and chest wall 2.5 litres
RV
residual volume
air left after maximal exhalation (1.5l)
25% of TLC
TV
tidal volume
air inhaled/exhaled each breath .5 l (females 20-25%less)
ERV
expiratory reserve volume
maximal exhalation volume from resting exhalation level (1 Litre in males)
IRV
volume of air that can be inspired after normal insipiration (3 Litres in males)
IC
Inspiratiory Capacity
Maximal volumme of air tha can be inspired from resting level 3.5 litres
VC
Vital Capacity
maximal volume of air that can be exhaled after maximal inspiration
TLC
Total Lung Capacity
Volume in lungs at end of maximal inhalation 6 litres
Lung Compliance
stretchability of lung for any 1 cm change in pressure
determined by elastic tissue in lung and surface tension generated at water-air interfaces withing alveoli