Respiratory System Flashcards

1
Q

Inspiratory muscles

A
Respiratory diaphragm
 - inc the volume of the cavity and creates and negative pressure to bring air in 
External intercostal muscles 
Sternomastoids 
Serratus anterior muscles 
Scalene muscles
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2
Q

Expiratory muscle

A

Passive at rest

Forceful: abdominal muscles, internal intercostals

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3
Q

What is lung capacity?

A

The maximum volume of gas the lungs can hold

A capacity is made up of two or more volumes

Total lung capacity is made of distinct, non-overlapping sub-compartments: lung volumes

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4
Q

What is the tidal volume?

A

500 ml

Volume of air that is inspired or expired with each breath at rest

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5
Q

Inspiratory reserve volume

A

3000 ml

Volume that can be inspired in addition to tidal volume with forceful inspiration

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6
Q

Expiratory reserve volume

A

1100 ml

The additional volume f air that can be expired at end of tidal volume by forceful expiration

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7
Q

Residual volume

A

1200 ml

Volume of air remaining in lungs after forceful expiration

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8
Q

What’s the difference between vital capacity and total lung capacity?

A

Vital capacity is 4600 ml
The sum of all the volumes that can be inspired or exhaled

Total lung capacity is 5800 ml. The sum of all the volumes = vital capacity plus residual volume

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9
Q

Minute ventilation

A

Total volume of gases moved into or out of the lungs per minute

(Breaths per minute) x (tidal volume) = minute ventilation

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10
Q

Alveolar ventilation

A

Total volume of gases that enter spaces participating in gas exchange per minute

(Breaths per minute) X (tidal volume - dead space) = alveolar ventihilation

0.35 L x breathing rate

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11
Q

Dead space

A

150 ml

Portions of the anatomy that don’t participate I n gas exchange: trachea, bronchi, bronchioles

Anatomic dead space + ventilated alveoli with poor or absent blood supply

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12
Q

What is transpulmonary pressure?

A

Difference between the alveolar pressure and the pleural pressure

Pleural pressure: pressure of the fluid between the parietal pleura and the visceral pleural

Alveolar pressure: pressure of the air inside the alveoli

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13
Q

What is lung compliance?

A

The extent to which lungs will expand for each unit increase in the transpulmonary pressure

In liters, normal: 200 ml/water cm

Measure of the expansibility of the lungs and trachea

Increase in vol/increase in pressure
Distensibility x volume

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14
Q

What is lung elastance?

A

Compliance is the reciprocal of elastance,

Elastance is the measure of the tendency of a hollow viscous to recoil towards it’s original dimension upon removal of the ditending or collapsing force.

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15
Q

What center’s of the brain are used for normal respiration?

A

Medullary respiration group:
dorsal respiratory group
the ventral respiratory group

Pontine repiratory centers: located in the pons.

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16
Q

What respiratory center establishes the ramp signal? What is the ramp signal?

A

Dorsal respiratory group

Nervous signals to inspiratory muscles

  • weak
  • then intense for 2 secs
  • stops for 3 allows expirations

Allows lung elasticity ^^

17
Q

What’s the main purpose of the PRG in regards to the ramp signal?

A

To control the switch-off point for the inspiratory ramp. PRG causes the ramp signals to stop abruptly

Strong PRG causes more breathing than normal

Weak PRG causes less breathing than normal

18
Q

What is apneusis? What center is it associated with?

A

Apneusis is the failiure to turn off inspiration

Pontine group: apneusis center. -> Gasping

Inferior pons

19
Q

Ventral respiratory group

A

Ventrolateral portion of the medulla

Usually inactive during normal respiration. Not part of oscillation that control normal breathing

Increased pulmonary ventihalition causes signals to spilllover from the DRG to the VRG with increases repiratory drive.

Contains expiratory neurons: botzinger complex

20
Q

Hering-Breuer Inflation Reflex

A

Relies is a protective mech to prevent excess inflation of the lungs

Shuts off the inspiratory ramp

-stretch receptors in the walls of the bronchi and bronchioles

21
Q

Chemoreceptors

A

increase their activity when hypoxia or hypercapnia occur

Hypercapnia - increased carbon dioxide

Central - sensitive to pH of blood
peripheral chemoreceptors

22
Q

Central chemoreceptors

A

Sensitive to pH of blood, carbon dioxide levels.
Or [H+]
-essentially the same thing because carbon dioxide dissociated into H+ and HCO3-

23
Q

Peripheral chemoreceptors

A

Sensitive to change in O2 levels.
In bifurcation of the common carotid in the carotid arteris and aortic arch.

Type I: glomus cells - chemosensors potassium channels that are oxygen dependent. ^ in O2, K+ release and hyperpolarization. O2 dec _> depolarization, Ca++ releases and NT release.

Type II - support cells, like glial cells

24
Q

Mechanoreceptors

A

Located in the airways of lungs
Sensitive to the stretch of airways
Causes: termination of inspiration and prolonged expiration

Important for controlling respiration in infants and adults during exercise

25
Q

J receptors

A

sensory ends in alveolar wall next to pulmonary capillaries

Sensitive to pulmonary edema

Travel Vargas nerve

Causes: cough, tachypnea

Override normal respiratory control centers

26
Q

What is cheyne-stokes breathing?

A

Abnormal pattern of breathing characterized by a repeating pattern

Increasingly deeper and rapid breathing - hyperpnea
Followed by a gradual decrease
Then a temporary stop - apnea
Pattern repeats: cycle about 30 sec to 2 minutes.

27
Q

How is periodic breathing or central sleep apnea syndrome different from Cheyenne-stokes breathing?

A

Essentially the same. In Periodic breathing instead of apnea you see hypopnea

If the above happens during sleep is central sleep apnea syndrome.
-damage to central repiratory centers

-abnormalities of the respirator neuromuscular apparatus

28
Q

What conditions override the damping factors that would stop Cheyne-stokes breathing from occuring?

A

A long delay in the transport of blood from the lungs to the brain like seen in cardiac failure

Increased negative feedback like seen in brain damage.
-pCO2 and pO2 feedback get out of sync