Respiratory System

Question 1

Bronchodialor

Answer 1

A.sympathomimetics
1.slective b2 agonist
Short acting-salbutamol,terbutaline
Longacting-Salmetrol,fenoterol,
2.non selectiveagents
adrenaline,isoperinalin,ephedrine
Bmethylxanthanes
-*theophyline,aminophyline
Canticholinergic
-ipratropium bromide ,titropium,atropine

Question 2

Sympathomimetics

Answer 2

Most useful drugs to reliev broncospasm
MOA
Adrenergic agonist
↓
b2 receptor stimulate
↓
Activate adenylel cyclase
↓
↑CAMP levels
↓
Bronchodialation

Question 3

Salbutamol

Answer 3

Short acting and selective b2 agonist
Fastest bronchodialators
Peak effect in 10 mins lasts 3-4 hrs
Most effective
Convenient
Relatively safe

Available as meter dose inhalers ,nebulizer, injection,tablet

A/E
Skeletal muscle tremors
Palpitations
Nervousness
Anxiety
On oral administration, salbutamol undergoes first pass metabolism bioavailability 50%