respiratory phys 7 Flashcards
what is spontaneous respiration regulated by? how is THAT controlled?
- spontaneous respiration is regulated by rhythmic discharges coming from motor neurons from the pons and medulla that are controlled by chemical control and changes in arterial PO2 and PCO2 and H+ concentrations
- can also be supplemented by nonchemical influences
where is the voluntary respiratory control system
in the cerebral cortex
sends impulses to respiratory motor neurons located in spinal cord via the cortico-spinal tracts
why do we not inhale and exhale at the same time
the expiratory muscles are inhibited when those supplying the inspiratory muscles are active and vice-versa
walk through the steps of where the signal goes thru when there is a change in oxygen or CO2 or pH. what is an exception to this pathway?
- sent to PERIPHERAL chemo-receptors
- sent to sensory integration
- sent to central pattern generator
- out to spinal cord
- then to respiratory muscles and out to chest wall, diaphragm, conducting airways to increase ventilation
-> exception to this pathway is when there’s a large CO2 increase and that signal gets sent straight to central chemo receptors that goes to the CENTRAL pattern generator
What is the main controller of respiration? what are it’s properties in the body
- pCO2 is the major controller of respiration
- high colubility and no Hgb buffer
- acute increases in pCO2 have a stronger effect than decreases in pH
WHAT CAN INCREASE PO2?
- normally, an increase in CO2 causes an increase in O2 however, in the absence of CO2, O2 is increased anyway with the decrease in O2 via the PERIPHERAL CHEMORECEPTOR
when is the peripheral chemoreceptor system particularly sensitive to changes in arterial PO2?
- from 60-30 mmHg
- this is a range in which Hgb saturation with oxygen decreases rapidly
what effect does H have on chemoreceptors and why
H stimulates the chemosensitive area but CO2 in the fluid give rise to most of the H
- > how? when there is CO2, it conjugates with H2o and enters the blood brain barrier to dissociate as bicarb and H+
reason: since H does not easily cross the blood brain barrier, it changes in blood H have considerably less effect in stimulating the chemosensitive neurons than do changes in blood CO2
what are the main peripheral chemoreceptors? what do they respond to the most? secondarily?
aortic and carotid bodies
-respond to changes in O2 first but also respond to a lesser extend to CO2 ad pH (H)
what are the main central chemoreceptors? what do they respond to
- they are located in the ventral lateral medullary surface as the 1) rostrel area 2) intermediate area 3) caudal area
- sensitive to H and PCO2
- in turn excites other portions of the respiratory center
what is the sensory integration system?
-it is where all the chemoreceptors and baroreceptors come together on the respiratory center
what are the four main neurons that are in the respiratory center
- DRG- dorsal respiratory group-
- PRG- pneumotaxic respiratory group
- Ventral respiratory group pre- botzinger complex
what is the pre botzinger complex
- pacemaker cells that initiate rhythmic respiration
- on both sides of the medulla between the nucleus ambiguous and lateral reticular nucleus
what is the dorsal respiratory group
- sends out repetitive bursts of inspiratory neuronal action potentials (inspiratory ramp signals)
what is the pneumotaxic center?
- it’s located in the nucleus parabrachialis of the upper pons
- transmits signals to the inspiratory area (DRG) and decreases activity of DRG and inspiration to allow for expiration
- control the switch- off point of the inspiratory ramp
