Respiratory Medications - Quiz 5 Flashcards
What is the technique for using Inhalers?
Slow Deep Breath over 5 seconds, Hold for 10 seconds, then Blow all out
What is the problem w/ using a Metered Dose Inhaler?
Only 12% gets to lungs, even less w/ ETT
How much more med is needed w/ a Nebulizer vs. an MDI?
6-10x more needed
How should Bronchodilators & Corticosteroids be adminstered?
Bronchodilators BEFORE Corticosteroids
Which Muscarinic Receptors are Stimulatory?
M1, M3, M5
Which Muscarinic Receptors are Inhibitory?
M2 & M4
What are the effects of Inhaled Atropine?
↓Airway Resistance
&
↑Dead Space
Which COPD meds contain Glycopyrrolate?
Seebri
Lonhala
Bevespi
When is Glycopyrrolate NOT indicated?
Acute COPD Symptoms
Which meds are Short Acting Muscaranic Antagonists (SAMA)?
Atropine
Glycopyrrolate
Ipratropium
What are the advantages of using Ipratropium?
Minimal Systemic Absorption
No Bronchodilator Tolerance
More effective for Chronic Bronchitis/Emphysema
What are the disadvantages of using Ipratropium alone vs. a Beta Agonist?
Slower Onset (30-90 min)
&
Less Effective
How does Tiotropium (Spiriva) work?
Blocks M1 & M3 Muscarinic Receptors
What does Tiotropium (Spiriva) do?
Bronchdilation
&
↓Secretions
How does Aclidinium compare to Tiotropium?
Faster Onset to Peak
Take BID vs Daily
Aclidinium + Formoterol = ?
Duaklir
Which meds are Long Acting Muscarinic Antagonist (LAMA)?
Tiotropium
Aclidinium
Umeclidinium
What are side effects of Inhaled Anticholinergics?
Glaucoma
&
Urinary Retention
What is the Gold Standard for treating Acute Bronchospasms?
Beta 2 Agonists
What gives Beta-2 Agonist their long duration of action?
They’re Non-Catecholamines - resistant to COMT
What is the advantage of using newer Inhaled Beta-2 Agonists at therapeutic doses?
Relax Bronchial Smooth Muscle WITHOUT stimulating the Heart
What are Inhaled Beta-2 Agonists used for?
Treats & Prevents Acute Asthma
↑Airflow
↑Exercise Tolerance
Tocolytic Therapy
Treats Hyperkalemia
How long do Short Acting Beta 2 Agonist (SABA) last?
3-6 hours
How long do Long Acting Beta 2 Agonists (LABA) last?
> 12 hours
Which pressors have Beta-2 effects, but also a lot of Non-Respiratory side effects?
Ephedrine
&
Epinephrine
Which med was reapproved to treat Mild Asthma?
Primatene Mist - Inhaled Epinephrine
What is the preferred Beta-2 Agonist for Acute Bronchospasms?
Albuterol
Onset: 15 min
Peak: 1 hour
What is the R-Enantiomer of Albuterol?
Levoalbuterol (Xopenex)
Which Beta-2 Agonists were used as Tocolytics?
Terbutaline
&
Ritodrine
Which meds are Long Acting Beta 2 Agonists (LABA)?
Salmeterol
Vilanterol
Formoterol
Aformoterol
Which meds are Short Acting Beta 2 Agonists (SABA)?
Albuterol
&
Levoalbuterol