Respiratory Infection I Flashcards
What structures exist within the nasal cavity to help rid the body of particles & pathogens?
- hairs (filter large particles)
- turbinate bones
- air swirls as it passes & forces particles to contact mucous
After the nasal cavity, what structures of the respiratory tract help rid the system of particles & pathogens?
- Change in air-flow direction after nasal cavity
- particles impinge in back of throat
- adenoids & tonsils
- lymphoid organ that help with immune response
- mucosal surfaces
- trap particles & pathogens
- Cilia
- drive mucus upwards to back of throat
- Sneeze & cough reflex
What are the 2 main functions of the microbiota of the respiratory tract?
- compete with pathogenic organisms for potential attachment sites
- produce substances that are bactericidal & prevent infections by pathogens
What is the most important means of eliminating pathogenic organisms that enter the lungs?
alveolar macrophages
List the location & most common pathogens the cause the following disease:
Common cold (nonspecific URI)
Nasal passage
Rhinovirus
What pathogen is the most common cause of summer grippe?
various enteroviruses
Enterovirus, Coxsackievirus, Echovirus
What characteristics can help you differentiate between the common cold & summer grippe?
Colds usually do not cause a fever & are most common in the winter
Summer grippe usually results in a fever & is most common in summer months
Identify the diagnosis based on the following symptoms
general malaise, lacrimation, sore throat, no fever, anosmia/hypoasmia, ageusia/hypogeusia, anorexia
winter month
cough & substernal discomfort
common cold
SARS-CoV2 infection can cause what additional symptoms to the common cold?
fever, anosmia, ageusia & is not limitd to the winter months
GI discomfort
common all year long
Identify the diagnosis based on the following symptoms:
fever, malaise, headace, possible uper respiratory symptoms, possible nausea & vomiting
summer month
lasts 3-4 days
Summer Grippe
Describe the general transmission of the viruses tha cause the Common Cold, Summer Grippe & SARS-CoV-2
- Common Cold: person to person, usually hand-to-hand contact
- SARS-CoV-2: droplets, aerosols & contact with contaminated objects
- Summer grippe: fecal oral means
What is the receptor
What is the receptor that SARS-CoV-2 is able to attach to on the host cell?
ACE-2
angiotensin converting enzyme-2
How long does it take the common cold to reach its pathological peak?
2 - 4 days
What illness fits the following pathogenesis?
Days 1-2: runny nose, clear mucoid nasal secretions
Day 2: Secondary bacterial infection from respiratory microbiota & secretions become purulent
Common cold
The common cold can cause what complications?
blockage of the sinus ostia / eustacian tube, leading to acute rhinosusitis or otitis media
compilcations are usually related to bronchitis
What is the treatment for Summer Grippe & the Common Cold?
supportive thearpy to ease discomfort
What are the 4 preventative measures to avoid infection by SARS-CoV-2?
- vaccine
- social distancing
- masks
- handwashing
What measures can be taken to avoid the common cold in children and in adults?
- Children:
- probiotics
- vitamin C
- zinc sulfate
- nasal saline irrigation
- Adults:
- garlic
- vitamin C
- Both
- handwashing & disinfecting?
What is the definintion of rhinosinusitis?
inflammation or infection of the mucosa of the nasal passages and at least one of the paranasal sinuses that lasts no longer than 4 weeks
What are the most common etiological causes of rhinosinusitis?
Respiratory viruses:
- rhinovirus
- parainfluenza virus
- respiratory syncytial virus
- adenovirus
How does acute bacterial rhinosinusitis usually occur?
Most common etiological causes?
as a complication of acute viral rhinosinusitis
- Streptococcus pneumoniae
- Haemophilus influenzae
What is Rhinocerebral mucormycosis?
Most common etiological agents?
invasive, life-threatening fungal infection
Rhizopus, Rhizomucor
(less commonly) Aspergillus & Fusarium
Identify the diagnosis based on the following symptoms:
sneezing, rhinorrhea, nasal congestion, post nasal drip, aural fullness, facial pressure & headache, sore throat, cough & fever and myalgias
less than 4 weeks duration
acute rhinosinusitis
What is a complication of advanced frontal rhinosinustis?
Pott’s puffy tumor
soft tissue swelling & pitting edema over frontal bone from superiostal abscess
Identify the diagnosis based on the following symptoms:
upper respiratory tract infection, blood nasal discharge, dusky or necrotic turbinates, changes in metal state, black eschar of the palate
rhinocerebral mucormycosis
At what time of year is rhinosinusitis most commonly occur?
winter months
What type of patients are most susceptible to rhinocerebral mucormycosis?
immunocompromised
diabetic w/ ketoacidosis, transplant recipient, patients w/ hematologic malignancies & patients on chronic glucocorticoid or deferoxamine therapy
What virulence factor allows Streptococcus pneumoniae to cause bacterial acute bacterial rhinosinusitis?
capsule
protects it from phagocytosis
What virulence factor allows Haemophilus influenzae to cause bacterial acute bacterial rhinosinusitis?
LOS
helps it to bind to host nonciliated epithelial cells
causes an increase in mucin production by host cells
What symptoms would help you differentiate between bacterial & viral acute rhinosinusitis?
bacterial is more likely when persists beyond 7 days or severe symptoms of any duration
persistent fever, altered mental status, diplopia (double vision), infraorbital hypesthesia (diminished physical sensatio)
What are treatment options for patients with acute rhinosinusitis?
increase oral hydration, nasal saline & steam
antipyretics, analgesics, decongestants & mucolytics
What are the 3 major factors for successful cerebral mucormycosis?
- Reversal of underlying predisposition
- Aggressive surgical debridement
- removal of all dead tissues & severely compromised tissue
- Aggressive antifungal therapy
What are strategies to prevent acute viral or bacterial rhinosinusitis?
- Good management of allergies
- Not getting flu or common cold
- Avoid jumping in water without plugging the nose
- Have septal deviation corrected & polyps or foreign bodies surgically removed
- Practice proper dental management
What is a strategy to prevent rhinocerebral mucormycosis?
encouraging diabetic patients to maintain good control over serum glucose levels
What is pharyngitis?
sore throat
Most common etiological causes of bacterial pharyngitis?
- S. pyogenes* (B-hemolytic group A Streptococcus)
- Neisseria gonorrhoea* (following oral sex)
Identify the diagnosis based on the following symptoms:
fever, sore throat, edema, hyperemia of tonsils and pharyngeal walls
pharyngitis
What symptoms suggest a viral rather than bacterial agent causing pharyngitis?
conjunctivitis, cough, coryza, hoarseness, anosmia, ageusia & diarrhea
anterior stomatitis and discrete ulcerative lesions & viral exanthem
What finding is specific for S. pyogenes pharyngitis?
scarlet fever rash
What are complications that can develop from untreated S. pyogenes pharyngitis?
- Suppurative: peritonsillar abscess, cervical lymphadenitis & mastoiditis
- Nonsuppurative: acute glomerulonephritis & rheumatic fever
What is acute glomerulonephritis?
sudden onset of hematuria, proteinuria & red blood cell casts
hypertension, edema & impaired renal function
What are the most common causes of acute pharyngitis?
viruses
- rhinovirus
- COVID
- adenovirus (military & boarding schools)
- HSV
- Parainfluenza (children)
- Influenza
- Coxsackievirus
- RSV (children)
- Epstein-Barr (adolescents)
What virulence factors allow S. pyogenes to cause bacterial pharyngitis?
M-protein (prevents phagocytosis)
lipoteichoic acid
fibronectin-binding protein (protein F)
capsule with hyaluronic acid
protease & hyaluronidase
Why can S. pyogenes cause damage to renal & heart tissue?
M protein shares antigenic epitopes with heart & renal tissue
antibody made to certain type sof M protein can cross reaction with heart tissue causing carditis
What bacteria is B-hemolytic, catalase-negative, gram-positive cocci & sensitive to bacitracin?
S. pyogenes
How should the diagnosis of Group A Strep pharyngitis established?
- Testing by rapid antigen detection tests (RADT)
- in children, (-) RADT should be backed up by throat culture
- Back up cultures of (-) RADT is not necessary for adults b/c risk rheumatic fever is v. low
- Anti-streptococcal antibody titer non recommended (reflect past events)
Who should & shouldn’t be tested for GAS pharyngitis?
- Shouldn’t
- if strongly suggest viral etiology
- under 3 yrs old
- follow-up post treatment
- asymptomatic household contacts of patients with GAS pharyngitis
- Should
- under 3 w/ older sibling with GAS infection
What is the general treatment for acute pharyngitis?
antipyretics, analgesics & supportive care
There is an adenovirus vaccine available for what demographic of people?
military
not recommended for general public
What is the treatment for S. pyogenes pharyngitis?
antipyretics, analgesics & supportive care
antimicrobials