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Arizona Drug Profiles > Respiratory Drugs > Flashcards

Respiratory Drugs Flashcards

1
Q

what is the MOA of albuterol

A

B agonist primarily B2, relaxes bronchial smooth muscle resulting in bronchodilation, also relaxes uterine smooth muscle, decreases airway resistance

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2
Q

when is the administration of albuterol indicated

A

treatment of bronchospasm

treatment of hyperkalemia

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3
Q

when is albuterol contraindicated

A

synergistic with other sympathomimetics

caution in pts with diabetes, hyperthryroidism, cerebrovascular disease

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4
Q

what adverse reactions are associated with albuterol

A 
dysrhythmias tachycardia peripheral vasodilation
bronchospasm
tremors, nervousness
nausea vomiting
hyperglycemia
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5
Q

what drug types is albuterol incompatible with

A

TCAs MAO inhibitors Sympathomimetics

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6
Q

what is the expected onset of action of albuterol

A

5-15 minutes

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7
Q

when do the peak effects of albuterol occur

A

30 mins- 2 hours

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8
Q

what is the duration of action of albuterol

A

3-4 hours

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9
Q

what is the MOA of Dexa

A

improves lung function and myocardial performance: stabilization of lysosomal and cell membranes, inhibition of compliment induced granulocyte aggregation, rihtward shift in oxygen hemoglovin dissociation curve, inhibition of prostaglandin and leukotriene production, increase in surfactant production, decrease in pulmonary edema, relaxation of bronchospasm

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10
Q

when is administration of dexa indicated

A

acute exacerbation of bronchial asthma
anaphylaxis
cerebral edema

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11
Q

when is dexa contraindicated

A

systemic fungal infections
hypersensitivity to any component, including sulfites
preterm infants

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12
Q

what adverse reactions are associated with dexa

A

na retention, fluid retention, potassium loss, hypokalemic alkalosis, hypertension, convulsions, hyperglycemia, myocardial rupture following recent MI

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13
Q

what drugs is dexa incompatible with

A

benadryl and versed in IV tubing

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14
Q

what are the adult and peds doses of dexa for reactive airway disease

A

adult: 8-24mg
peds: 0.25-0.5 mg/kg

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15
Q

what are the adult and peds doses of dexa for cerebral edema

A

adult: 1-5 mg/kg
peds: 0.5-1.5 mg/kg

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16
Q

what are the routes of administration for dexa

A

iv, io, im

17
Q

what is the onset of action for dexa

A

4-8 hours

18
Q

when are the peak effects of dexa expected

A

6-12 hours

19
Q

what is the duration of action of dexa

A

24-72 hours

20
Q

what is the drug classification of atrovent

A

anticholinergic, bronchodilator

21
Q

atrovent appears to inhibit _________ mediated reflexes by antagonizing the action of ach

A

vagally

22
Q

when is administration of atrovent indicated

A

treatment of bronchospasm associated with copd

23
Q

when is atrovent contraindicated

A

hypersensitivity to atrovent or atropine

precaution should be used in pts with narrow angle glaucoma

24
Q

what adverse reactions are associated with atrovent

A

coughing, sputum increased
dizziness, insomnia, tremor, nervousness
nausea

25
Q

what is the adult and peds dose of atrovent

A

500mcg in 2.5 ml NS

same for pediatric pts, but dose cannot be repeated

26
Q

what is the expected onset of action of atrovent

A

5-15 minutes

27
Q

when are the peak effects of atrovent expected

A

1-2 hours

28
Q

what is the duration of action of atrovent

A

4-8 hours

29
Q

atrovent produces dilation of ________ while albuterol produces dilation of _______

A

larger central airways

peripheral airways

30
Q

how is magnesium sulfate administered when used to treat severe asthma

A

2 grams in 50ml bag of NS or D5W, use microdrip tubing, administer over 5-10 minutes

31
Q

when should an infusion of magnesium sulfate be stopped when it is used to treat severe asthma

A

when hypotension, bradycardia, or respiratory depression develop

32
Q

what is the MOA of solumedrol

A

thought to stabilize cellular and intracellular membranes

33
Q

when is the administration of solumedrol indicated

A

acute exacerbation of copd

burns potentially involving the airway

34
Q

when is the administration of solumedrol contraindicated

A

pre term infants

35
Q

what is the adult dose of solumedrol

A

125 mg slow iv bolus

36
Q

what is the pediatric dose of solumedrol

A

2-4 mg/kg slow iv bolus

37
Q

what is the expected onset of action of solumedrol

A

1-6 hours

38
Q

when are the peak effects of solumedrol expected

A

8 hours

39
Q

what is the duration of action of solumedrol.

A

18-36 hours

Arizona Drug Profiles (5 decks)

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