Respiratory Disorders Flashcards
Legionnaires Disease
- Legionella Pneumophila
- Gram Negative
- Has extrapulmonary manifestations
- Transmission is droplets via mist
- Incubation 2-10 days
- Diagnose with PCR, urinary antigen, patchy unilobar infiltrates
Acute Bacterial Pneumonia
- Streptococcus Pneumoniae
- resides in respiratory tract of 70% of people
- Transmission via respiratory droplets or aspiration
- incubation 24-48 hours
Septic Pneumonia Manifestations
- Increase WBC
- Increase procalcitonin
- acidosis
- (+) blood culture
- abnormal kidney/liver function
Pneumonia Interventions
- Antibiotic, antifungal, antiviral
- Bronchodilators
- mucolytics, expectorants
- IV fluids
- O2
- diet high in protein, rest
- chest physiotherapy
Aspiration Pneumonia
- Caught through aspiration
- predisposing factors: neurological disorder, upper GI disorder, mechanical disruption
Pneumocytosis Jiroveci Pneumoniae
-Opportunistic
-airborne transmission
-incubation up to 197 days
-diagnosed with:
diffuse, bilateral, interstitial infiltrates
tinctorial staining
fluorescent antibody
PCR
Viral Pneumonia
- airborne transmission
- responsible for 10% of cases
- incubation 2-5 days
- organisms: RSV, flu, adenovirus, measles, covid
Primary Atypical Pneumonia
- Mycoplasma pneumoniae
- gram negative
- manifestation: URI, acute bronchitis, CAP
- transmission: respiratory droplets
- incubation 2-3 weeks
- diagnosis: hemolysis main, patchy opacities, streaks of interstitial infiltrates, areas of atelectasis
Pneumonia Manifestations
Neuro: headache, mood swings, confusion
Respiratory: dyspnea, cough, crackles, sputum, hemoptysis, hypoxia
Cardiovascular: pleuritic pain, tachycardia
Integumentary: fever, chills, fatigue, malaise
gastro: loss of appetite, nausea, vomiting
Pneumonia Classifications
- Community Acquired: streptococcus pneumoniae, influenza
- Healthcare Associated: ventilator associated, pseudomonas aeruginosa, escherichia coli
- Opportunistic: pneumocystis jiroveci, mycobacterium tuberculosis
Pneumonia Pathophysiology
Affects the parenchyma, caused by aspiration of microorganisms thru nasopharynx, they get trapped in cilia and lead to alveolar edema –> dyspnea, hypoxemia
TB Treatment Lengths
Latent: 1 to 2 antibiotics for 12-16 weeks
Active: 3 to 4 antibiotics for 18-31 weeks
TB Pharmacological Treatments
Isoniazid -used for prophylaxis, 1st line treatment -peripheral neuropathy is the # 1 side effect due to B6 deficiency Rifampin -Combination drug -red/orange body fluids is a symptom Ethambutol -treatment of active TB in combination -Optic neuritis is as symptom Pyrazinamide -hepatoxicity
TB isolation precaustions
Airborne isolation precautions
Can be removed if: clinical improvement, on meds minimum of 2 weeks, 3 consecutive negative AFB smears
TB Sputum Tests
Sputum Smear -read in 24 hours -(+) acid fast bacteria -need 3 specimens, 8-24 hours apart Sputum Culture -gold standard -growth of tubercle bacilli -confirms TB diagnosis
TB Blood Tests
IGRA -for people who had BCG -Can't be followed up QuantiFERON TB gold T-spot TB test
TB Skin Test
TST, PPD Test, Mantoux test
- intradermal
- read within 2-3 days
- negative TB test means TB is unlikely
- must have a 2nd test if positive
TB Manifestations
- chest pain
- weight loss
- chills
- long-term cough
- fever
- fatigue
- night sweats
- no appetite
- cough up blood
TB Pathophysiology
TB inhaled thru airborne droplets, they multiply in the alveoli, macrophages and T-Lymphocytes form granulomas, some TB is released when macrophages die and spread in blood
CPAP vs BiPAP
CPAP
-continuous pressure on inhale
BiPAP
-Pressure during inhale and exhale
OSA risk factor reduction
- Weight loss
- Smoking Cessation
- Avoid supine position when sleeping
- Limit alcohol
- CPAP and BiPAP
OSA Diagnostic Criteria
STOP & BANG test more than 5 checked recommend for a sleep study
Polysomnography
OSA Manifestations
- Snoring
- AM headache
- Excessive daytime sleepiness
- mood change
- difficulty concentrating
- waking with chest pain/dry mouth
OSA pathopysiology
While awake small airway and neuromuscular compensation, at sleep onset you loose neuromuscular compensation and decreased pharyngeal muscle activity and the airway collapses. Apnea occurs leading to hypoxia and hypercapnia and increased ventilary effort. This leads to arousal, and airway is restored, and hyperventilation occurs