Respiratory conditions Flashcards

1
Q

Presentation of bronchiolitis

A
  • Coryzal symptoms. These are the typical symptoms of a viral upper respiratory tract infection: running or snotty nose, sneezing, mucus in throat and watery eyes.
  • Signs of respiratory distress
  • Dyspnoea (heavy laboured breathing)
  • Tachypnoea (fast breathing)
  • Poor feeding
  • Mild fever (under 39ºC)
  • Apnoeas are episodes where the child stops breathing
  • Wheeze and crackles on auscultation
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2
Q

Brochiolitis occurs in what age of children? Most common in what age?

A

under 1 year
It is most common in children under 6 months.

It can rarely be diagnosed in children up to 2 years of age, particularly in ex-premature babies with chronic lung disease.

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3
Q

Signs of respiratory distress

A
  • Raised respiratory rate
  • Use of accessory muscles of breathing, such as the sternocleidomastoid, abdominal and intercostal muscles
  • Intercostal and subcostal recessions
  • Nasal flaring
  • Head bobbing
  • Tracheal tugging
  • Cyanosis (due to low oxygen saturation)
  • Abnormal airway noises
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4
Q

Aetiology of bronchiolitis

A

When a virus affects the airways of adults, the swelling and mucus are proportionally so small that it has little noticeable effect on breathing.
The airways of infants are very small to begin with, and when there is even the smallest amount of inflammation and mucus in the airway it has a significant effect on the infants ability to circulate air to the alveoli and back out. This causes the harsh breath sounds, wheeze and crackles heard on auscultation when listening to a bronchiolitic baby’s chest.

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5
Q

causes of bronchilotis (most common)

A

virus.
Respiratory syncytial virus (RSV) is the most common

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6
Q

definition of bronchiolitis

A

inflammation and infection in the bronchioles, the small airways of the lungs.

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7
Q
  • What are the 3 abnormal airway noises to be aware of in children
A
  • Wheezing is a whistling sound caused by narrowed airways, typically heard during expiration
  • Grunting is caused by exhaling with the glottis partially closed to increase positive end-expiratory pressure
  • Stridor is a high pitched inspiratory noise caused by obstruction of the upper airway, for example in croup
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8
Q
  • Criteria for admission in bronchiolitis
A
  • Aged under 3 months or any pre-existing condition such as prematurity, Downs syndrome or cystic fibrosis
  • 50 – 75% or less of their normal intake of milk
  • Clinical dehydration
  • Respiratory rate above 70
  • Oxygen saturations below 92%
  • Moderate to severe respiratory distress, such as deep recessions or head bobbing
  • Apnoeas
  • Parents not confident in their ability to manage at home or difficulty accessing medical help from home
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9
Q
  • Typical RSV course
A
  • starts as an upper respiratory tract infection (URTI) with coryzal symptoms.
  • From this point around half get better spontaneously.
  • other half develop chest symptoms over the first 1-2 days following the onset of coryzal symptoms.
  • Symptoms are generally at their worst on day 3 or 4.
  • Symptoms usually last 7 to 10 days total and most patients fully recover within 2 – 3 weeks
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10
Q

Management of bronchiolitis

A

Typically patients only require supportive management. This involves:

  • Ensuring adequate intake. This could be orally, via NG tube or IV fluids depending on the severity. It is important to avoid overfeeding as a full stomach will restrict breathing. Start with small frequent feeds and gradually increase them as tolerated.
  • Saline nasal drops and nasal suctioning can help clear nasal secretions, particularly prior to feeding
  • Supplementary oxygen if the oxygen saturations remain below 92%
  • Ventilatory support if required

There is little evidence for treatments such as nebulised saline, bronchodilators, steroids and antibiotics.

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11
Q
  • Children who have had bronchiolitis as infants are more likely to have….. during childhood.
A

viral induced wheeze

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12
Q
  • How long do bronchiolitis symptoms last usually?
A

7 to 10 days total and most patients fully recover within 2 – 3 weeks

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13
Q
  • Most patients with bronchiolitis fully recover within ..
A

2-3 weeks

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14
Q
  • Ventilatory support : when is it needed?
A

As breathing gets harder, the child gets more tired and less able to adequately ventilate themselves.
They may require ventilatory support to maintain their breathing. This is stepped up until they are adequately ventilated:

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15
Q
  • Ventilatory support: different escalations
A
  1. **High-flow humidified oxygen **via tight nasal cannula (i.e. “Airvo” or “Optiflow”). This delivers air and oxygen continuously with some added pressure, helping to oxygenate the lungs and prevent the airways from collapsing. It adds “positive end-expiratory pressure” (PEEP) to maintain the airway at the end of expiration.
  2. Continuous positive airway pressure (CPAP). This involves using a sealed nasal cannula that performs in a similar way to Airvo or Optiflow, but can deliver much higher and more controlled pressures.
  3. Intubation and ventilation. This involves inserting an endotracheal tube into the trachea to fully control ventilation.
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16
Q
  • How do you assess ventilation?
A

Capillary blood gases are useful in severe respiratory distress and in monitoring children who are having ventilatory support.

17
Q
  • Most helpful signs of poor ventilation are:
A
  • Rising pCO2, showing that the airways have collapsed and can’t clear waste carbon dioxide.
  • Falling pH, showing that CO2 is building up and they are not able to buffer the acidosis this creates. This is a respiratory acidosis. If they are also hypoxic, this is classed as type 2 respiratory failure.
18
Q

what is palivizumab and what is it used for?

A

Palivizumab is a monoclonal antibody that targets the respiratory syncytial virus.

A monthly injection is given as prevention against bronchiolitis caused by RSV.

19
Q
  • Who gets given palivizumab?
A

It is given to high risk babies, such as ex-premature and those with congenital heart disease

20
Q

mechanism of action of palivizumab

A

**It is not a true vaccine **as it does not stimulate the infant’s immune system.
It provides **passive protection **by circulating the body until the virus is encountered, as which point it works as an antibody against the virus, activating the immune system to fight the virus.

The levels of circulating antibodies decrease over time, which is why a monthly injection is required.

21
Q

what prevention treatment for bronchiolitis is available

A

Palivizumab

22
Q

Croup typically affects children aged..

A

6 months to 3 years (mostly 6months to 2 years)

23
Q
  • The classic cause of croup that you need to spot in your exams, is
A

Parainfluenza virus

24
Q
  • Croup usually improves in less than…and responds well to treatment…
A

It usually improves in less than 48 hours and responds well to treatment is steroids, particularly dexamethasone.

25
Q
  • Main pathology that croup causes
A

laryngeal oedema and secretions

26
Q
  • Common causes for croup
A

The common causes for croup are:

  • Parainfluenza
  • Influenza
  • Adenovirus
  • Respiratory Syncytial Virus (RSV)
27
Q
  • Croup caused by … leads to epiglottitis and has a high mortality.
A

diphtheria

28
Q
  • Croup caused by diphtheria leads to…
A

epiglottitis and has a high mortality
rare due to vaccination

29
Q
  • Croup presentation
A
  • Increased work of breathing
  • Barking” cough, occurring in clusters of coughing episodes
  • Hoarse voice
  • Stridor
  • Low grade fever
  • coryzal symptoms
30
Q
  • Management of croup
A
  • single dose of oral dexamethasone (0.15mg/kg) to all children regardless of severity
  • repeated after 12 hours if necessary
  • prednisolone is an alternative if dexamethasone is not available
  • Most cases managed at home with simple supportive treatment (fluids and rest).
  • During attacks sit child up and comfort them.
  • avoid spreading infection, for example hand washing and staying off school.
31
Q
  • Stepwise options in severe croup to get control of symptoms
A
  • Oral dexamethasone
  • Oxygen
  • Nebulised budesonide
  • Nebulised adrenalin
  • Intubation and ventilation
32
Q

CKS suggest admitting any child with moderate or severe croup. Other features which should prompt admission include:

A
  • < 6 months of age
  • known upper airway abnormalities (e.g. Laryngomalacia, Down’s syndrome)
  • uncertainty about diagnosis (important differentials include acute epiglottitis, bacterial tracheitis, peritonsillar abscess and foreign body inhalation)
33
Q

Investigations in croup

A

the vast majority of children are diagnosed clinically
however, if a chest x-ray is done:
* a posterior-anterior view will show subglottic narrowing, commonly called the ‘steeple sign’
* in contrast, a lateral view in acute epiglottis will show swelling of the epiglottis - the ‘thumb sign’

34
Q

what type of infection is croup

A

upper respiratory tract infection

35
Q

Clinical Knowledge Summaries (CKS) suggest using the following criteria to grade the severity of croup:

A

Mild
* Occasional barking cough
* No audible stridor at rest
* No or mild suprasternal and/or intercostal recession
* The child is happy and is prepared to eat, drink, and play

Moderate
* Frequent barking cough
* Easily audible stridor at rest
* Suprasternal and sternal wall retraction at rest
* No or little distress or agitation
* The child can be placated and is interested in its surroundings

Severe
* Frequent barking cough
* Prominent inspiratory (and occasionally, expiratory) stridor at rest
* Marked sternal wall retractions
* Significant distress and agitation, or lethargy or restlessness (a sign of hypoxaemia)
* Tachycardia occurs with more severe obstructive symptoms and hypoxaemia