Respiratory Flashcards
1
Q
Idiopathic pulmonary fibrosis [treatment]
A
Pirfenidone - antifibrinolytic that blocks TGF-beta stimualted collagen synthesis and fibroblast proliferation
Nintedanib - tyrosine kinase receptor blocker
2
Q
CURB-65 score
A
Out of 5 points:
- Confusion = 1
- Urea > 7mmol/L
- Resp rate >30/min
- BP - systolic <90mmHg or diastolic <60mmHg
- 65 - age > 65 years
3
Q
CURB-65 score(s) likely suitable for home treatment
A
0 or 1
4
Q
CURB-65 score(s) to be managed in hospital with assessment for ICU admission
A
3 - 5
5
Q
CURB-65 score(s) in which hospital/supervised treatment should be considered
A
2
6
Q
Cause of cystic fibrosis
A
Mutation in CFTR (cystic fibrosis transmembrane conductance regulator) - the most common mutation is delta.F508 but over 1000 mutations in the gene have now been described
7
Q
CF inheritance pattern and carrier rate
A
Autosomal recessive, 1 in 25
