respiratory Flashcards
parts of conductive system
nasal cavity, pharynx, larynx, trachea, bronchi
parts of transitional system
terminal bronchioles
parts of gas exchange system
respiratory bronchioles and alveoli
non-specific immune response
- mucous trapping
- mucociliary clearance
- phagocytosis
- air turbulence- generated by coughing and sneezing
specific immune response
- antibody production
- antibody-mediated phagocytosis
- cell- mediated immunity
- respiratory region of nasal cavity (largest part)
- respiratory portion lined by psuedostratified columnar epithelium with goblet cells
- lamina-propria contains tubulo-alveolar glands- mainly serous with lesser numbers of mucous and mixed glands
- conchae turbinates
- vestibular region of nasal cavity
- initial, external part of nasal cavity
- lined by haired skin and glands
- stratified squamous keratinized epithelium
- olfactory region of nasal cavity
- lined with olfactory epithelium, lacks goblet cells
- has neurons, supporting cells. basal cells
- along with respiratory region contain venous plexus with swell bodies
mucociliary apparatus
- pseudostratified ciliated columnar epithelium
- goblet cells– produce mucinogen granules
- movement of cilia removes mucus with trapped airborne inhaled particles such as dust and microorganisms
- cleaning apparatus of upper respiratory passages
larynx
- includes cartilage, vocal folds, skeletal muscle
- initial part of larynx=stratified squamous epithelium
- after vocal cords changes to pseudostratified ciliated columnar epithelium
trachea
- lined by ciliated psuedostratified columnar epithelium
- lamina propria and submucosa are clearly not demarcated
- serous glands in lamina propria/submucosa
- cartilagenous rings
- connective tissue adventitia
bronchus
- ciliated pseudostratified columnar epithelium
- smooth muscle, lamina propria, mixed bronchiole glands
- plates of hyaline cartilage
bronchioles
- lack cartilage and glands
- terminal
- respiratory
terminal bronchioles
- lined by ciliated cuboidal cells- few to no goblet cells
- muscularis mucosae
club “Clara” cells
- in terminal and respiratory bronchioles
- bulge at surface
- secrete surfactant-like substance which aids in maintaining patency of airway
- may have immune function
respiratory bronchioles
- ciliated cuboidal epithelium
- incomplete muscularis mucosae
- subdivide into alveolar ducts
alveolar ducts
- exchange system
- empty into alveolar sacs and alveoli
- walls are lined with simple squamous epithelial cells
- opening surrounded by smooth muscle
- empty into alveolar sacs and alveoli
alveolar sacs
- branch from alveolar sacs, lack smooth muscle
- lined by epithelial cells: Pneumocytes type I and pneumocytes type II
alveolar pores of Kohn
- neighboring alveoli connect via pores, equalization of pressure and collateral ventilation
- pores allow macrophage passage from one alveolus to another
alveolar septum and interstitium
- fibroblasts and capillaries
- collagen type 3
- collagen type 1 always present in conducting airways
- elastic fibers
pneumocyte type 1- squamous alveolar type 1 cell
- form walls of alveoli
- 95% alveolar surface area
- thin with occluding junctions to prevent fluid passage
- not mitotic
pneumocyte type II- granular alveolar type II cell
- 5% alveolar surface area
- secretory cell
- lamellar bodies produce surfactant
- can be mitotic and produces type 1 and 2 cells
surfactant
- phospholipoprotien
- reduces surface tension
- produced by type II cells
- cortisol stimulates production of surfactant in fetus
Air-Blood barrier
- cytoplasm of pneumocyte type I covered by surfactant
- two fused basal laminae of alveolar epithelium and endothelium of capillary
- endothelium
interalveolar septum
- granular pneumocyte= great alveolar cell pneumocyte type II
- granules of surfactant
- surfactant on surface of alveolar lining
- cytoplasm of pneumocyte type I
- pneumocyte type 1
pulmonary macrophages
- alveolar macrophages (PAMS)
- intervascular macrophages (PIMS)
pleura
- thoracic wall, diaphragm and mediastinum lined by parietal pleura, continuous with mediastinal and visceral pleura covering surfaces of lungs
- pleura is composed of simple squamous epithelial cells- mesothelial cells