Respiratory Flashcards

0
Q

Which muscles are used for increased effort inspiration.

A

Diaphragm, external intercostal lifts and expand cage.
Accessory muscles.
Neck muscles.
Shoulder girdle muscles.

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1
Q

Which muscles are used for quiet breathing for inspiration

A

Diaphragm and external intercostals stabilize rib cage

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2
Q

Which muscles are used for increased effort on expiration

A

Internal intercostals and abdominal wall muscles

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3
Q

Which nerve innervates the diaphragm

A

Phrenic C3,4,5

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4
Q

What is Tidal Volume

A

The volume of air moved in and out the lungs during normal breathing.

Typical Value: at rest 6-7ml/kg

During exercise 15ml/kg

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5
Q

What is the Inspiratory Reserve Volume

A

The amount breathed in as deep as possible after expiration.

Typical value 3,000ml

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6
Q

What is Expiratory Reserve Volume

A

After inspiration, breathe out as much as possible.

Typical value: 1,500 ml

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7
Q

What is the residual volume and why does it exist

A

It is the air that remains in the lungs after maximal expiration.
Typical value: 1000ml
The rigid nature if the thorax and pleural attachments prevent complete expiration.

It CANT be measured by spirometry.

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8
Q

What are the 4 lung volumes and what do they equal?

A

Tidal volume, IRV, ERV and Residual Volume

All 4 = Total Lung Capacity

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9
Q

How is vital capacity calculated?

A

Tidal Volume + IRV + ERV

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10
Q

What is the functional residual capacity

A

Residual Volume + ERV

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11
Q

What is the Vital Capacity

A

The volume after a maximal expiration is made after a maximal inspiration.

Typical Value: 5,000 ml

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12
Q

How do restrictive lung diseases affect lung volumes?

A

Reduces: Residual Volume, Functional Residual Capacity, Vital Capacity and Total Lung Capacity.

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13
Q

Give 3 examples of Obstructive Lung Diseases

A

Asthma, COPD, Emphesyma

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14
Q

What happens to the residual volume in Obstructive Lung Diseases

A

The residual volume is decreased.

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15
Q

How is the volume of exhaled air effected by a restrictive lung disease

A

Remains at similar rate but the total volume exhaled significantly decreased.

16
Q

How is the volume of exhaled air changed by an obstructive lung disease

A

Slower rate but fairly close to the total volume exhaled.

17
Q

How is FEV1/FVC ratio used to distinguish between obstructive and restrictive lung diseases

A

A ratio below 0.7 is considered OBSTRUCTIVE

A ratio above 0.7 is considered RESTRICTIVE

18
Q

What is the most important factor in airway flow?

A

The diameter of the airway as it is power of 4 in calculation

19
Q

What is compliance?

A

Compliance is the change in lung volume per unit change in intrathoracic pressure

But compliance is not equal throughout the lung.

20
Q

What is the aleveolar surfactant made up of and what is it produced by?

A

90% Phospholipid
10% Protein

Produced by Type II alveolar cells.

21
Q

What does the surfactant do?

A

The surfactant acts as a detergent to reduce alveolar surface tension.

  • increases pulmonary compliance
  • prevents atelectasis - collapse of the lung
  • aids alveolar recruitment
  • minimises alveolar fluid
22
Q

As alveolar volume increases, surfactant becomes…

A

More dispersed. Which equalises pressure between alveoli of different sizes.

23
Q

What is partial pressure of a gas

A

Partial pressure of a gas in a mixture of gases is the pressure it would exert if it was the only gas

24
Why is partial of oxygen lower in alveoli than atmosphere 21%?
- Inspired air is humidified in the upper airway - oxygen is taken up while CO2 is added. - body consumers more oxygen than it produces CO2 (1.25x)
25
How is partial pressure of a gas related to its solubility?
Partial pressure of a gas is inversely proportional to its solubility. The greater solubility the more molecules can be accommodated for a given partial pressure.
26
Oxygen Diffusing Capacity =...
Oxygen uptake/alveolar po2 - mean pulmonary capillary Po2
27
What epithelial cells line the nose and pharynx
Pseudo stratified
28
What epithelial cells like the trachea and bronchi
Columnar
29
What epithelial cells line the bronchioles
Cuboidal
30
What are the key features of respiratory alkalosis
Low PCO2, normal bicarbonate and hyperventilation
31
What are the key features of metabolic alkalosis
Normal PCO2, high bicarbonate. Loss of H+ eg. From vomiting
32
What are the main features if respiratory acidosis
High PCO2, high bicarbonate from renal compensation. Ventilatory failure.
33
What are the main features of metabolic acidosis
Low PCO2 from respiratory compensation, low bicarbonate Renal failure Diabetic ketoacidosis and shock
34
What factors would shift the Hb-O2 curve left?
High pH Low temp Low 2,3 DPG
35
What would cause the Hb-O2 curve to shift right
Low pH High temp High 2,3 DPG
36
What disease is an absent globin chain in hemoglobin
Thalassemia - unsurvivable
37
Example of a defective globin chain disease
Sickle cell disease Red cells sickle at low PO2
38
Example of a defective Fe Atom problem
Methemoglobin - drug induces MetHb can't carry O2