Respiratory

Question 1

Diphenhydramine, Dimenhydrinate

Answer 1

H1 antagonist 1st generation (Enter CNS)
Use: Allergy, motion sickness, sleep
SE: sedation, antimuscarinc, anti alpha adrenergic

Question 2

Clorpheniramine

Answer 2

H1 antagonist 1st generation
Use: Allergy, motion sickness, sleep
SE: sedation, antimuscarinic

Question 3

Loratidine, Fexofenadine, cetrizine, desloratadine

Answer 3

H1 antagonist (2nd Generation, no CNS)
Use: Allergy
SE: Less sedation

Question 4

Guifenesin

Answer 4

Expectorant

Question 5

N-Acetylcysteine

Answer 5

Mucolytic in CF patients, antidote for APAP overdose

Question 6

Dextromethorphan

Answer 6

Antitussive, antagonizes NMDA, codeine analog, mild opioid effect

Question 7

Pseudophedrine, Phenylephrine

Answer 7

Alpha Agonist (sympathomimetic), nasal decongestion
Use: edema, nasal congestion, COOK METH
SE: HTN, CNS anxiety

Question 8

Albuterol, Salmeterol, Formoterol

Answer 8

Beta 2 agonist, short acting and long acting (S/F)
Use: Asthma
SE: Tremor (salmeterol) and arrhythmia

Question 9

Theophylline

Answer 9

Inhibits PDE->Increase cAMP anc Bronchodilates

SE: cardio/neurotoxic, p450 metabolized, blocks adenosine actions

Question 10

Ipratropium, tiotropium

Answer 10

Antimuscarinic, Bronchodilation (competitive block)

Use: COPD

Question 11

Beclomethasone, Fluticasone

Answer 11

Corticosteroids for asthma
Use: inhibit cytokines, inactivate NF-kB and dec. TNF-Alpha, Chronic Asthma
SE: Candida

Question 12

Montelukast, Zafirlukast

Answer 12

Block Leukotriene receptors (in ASA induced asthma)

Question 13

Zileuton

Answer 13

Inhibits 5 Lipoxygenase pathway

Question 14

Omalizumab

Answer 14

Anti IgE, blocks Fc binding

Use: Allergic astma resistant to B2 agonist and steroids

Question 15

Methacholine

Answer 15

Muscarinic agonist, asthma challenge

Question 16

Bosentan

Answer 16

Antagonist of Endothelin receptors,

Use: Pulmonary HTN