Respiratory Flashcards

1
Q

Topic 1

A

Taking a Patient’s History in Respiratory Medicine

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2
Q
  1. Introduction
A

WIPE

Wash hands
Introduce yourself - “Hello, my name is …., I’m a medical student on the ward…”
Patient details - Confirm you have the right patient. Ask their name, DOB, address, check their wristband.
Establish rapport - smile, shake hands, eye contact.
(Find out who sent the patient into hospital i.e. GP, ED)

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3
Q
  1. Presenting Complaint (PC)
A

Ask the patient “So what has brought you in today?”. Establish what their main concern is.
Listen to what the patient has to say.
Then ask “Would you like to tell me anything more about this problem?”

Tip: Summarise back to the patient to check that you have accurately captured their concern before moving on.

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4
Q

When taking a respiratory history what presenting symptoms may the patient have or complain about?

A

Respiratory symptoms:
Cough
Sputum production
Breathlessness
Chest pain
Haemoptysis
Wheezing

Systemic symptoms:
Weight loss
Malaise
Night sweats

Note: acuity of onset, changes over time, change in symptoms with location.

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5
Q
  1. History of Presenting Complaint (HPC)
A

Obtaining a chronological description of the problem.

If the patient complains of pain - use
SOCRATES: site, onset, character, radiation, associated symptoms, timing, exacerbating
and relieving factors, severity.

In the meantime, you need to start developing your differential diagnosis. Enquire about: risk factors for any particular disease and any treatment they have had and their response to this treatment.

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6
Q

What could you say to the patient to link HPC to their background health check?

A

“Thank you for sharing everything so far. I don’t have any more questions about your main concern. What I’m going to do next is ask you some background health questions and your family history.”

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7
Q
  1. Past Medical History
A

Obtaining a detailed health record.

Ask the patient about:
- any significant illnesses they’ve had before.
- any previous operations and other procedures like angioplasty, stenting
- ask about mental health
- childhood history: prematurity, childhood infections such as whooping cough or measles.

Run through a screening checklist of illnesses with the patient using the mnemonic MJ THREADS (myocardial infarction, jaundice, TB, hypertension & heart disease, rheumatic fever, epilepsy, asthma & COPD, diabetes, stroke and TIA) - However, adapt to the patient you’re taking a history from.

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8
Q
  1. Drug history
A

Obtaining a detailed record of prescribed, OTC or complementary therapies.

Ask about responses to these

Is the patient complaint?

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9
Q

What are some common drugs with respiratory side effects?

A

Clopidogrel<Ticagrelor – unexplained breathlessness
Aspirin/NSAIDs – asthma
ACE inhibitors - cough
Beta-blockers – wheeze
Amiodarone – pulmonary toxicity
Methotrexate – pneumonitis>fibrosis
Nitrofurantoin – pneumonitis
Steroids/immunosuppressants – risk of opportunistic infection
Contraceptives – increase thromboembolism
Slimming pills (anorectogens) – Pulmonary hypertension

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10
Q
  1. Allergies
A

Asking the patient if they have any known allergies to drugs, food, elastoplast, latex etc.

If so, what reaction does the patient have?
Itching, rash, swelling, anaphylaxis, or other?

Have they had to stop any medications due to side effects?

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11
Q
  1. Family history (FH)
A

Ask about first-degree relatives, their age, their state of health or cause of death.

Ask about any diseases that run in the family e.g. emphysema, bronchiectasis or cystic fibrosis.

Ask about specific diseases relevant to their presenting complaint e.g. for asthma ask if any relatives have asthma, eczema, hay fever, nasal polyps .

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12
Q
  1. Social history (SH)
A

(Needs to be adapted according to the age of the patient and their medical problem.)

  • ask if the patient lives with anyone and if so, whom?
  • does the patient have any dependents?
  • ask the patient about their accommodation e.g. house, bungalow, tenth-floor flat?
  • do they go out at all? ask about hobbies
  • able to carry out their ADLs?
  • do they have social services support?
  • are they working? ask about occupational exposure, especially in respiratory history. Focus on any exposure to asbestos, organic materials e.g. hay, mushrooms, cotton or animals, coal dust.
  • any recent overseas travel? - relevant for TB
  • do they have pets?
  • do they drink alcohol? Note how often, units per week, perform CAGE if you suspect a problem.
  • smoking history - duration of smoking and no. of cigarettes per day, attempts made to give up including replacement substances such as nicotine patches and e-cigarettes.
  • recreational drug use - e.g. use of cannabis
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13
Q

What are the “top 10” respiratory conditions?

A

Acute and chronic cough
Asthma
Chronic obstructive pulmonary disease (COPD)
Pneumonia
Pulmonary tuberculosis
Pneumothorax
Pleural effusions
Lung cancer
Bronchiectasis
Interstitial lung disease

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14
Q

“Top ten” concepts in respiratory medicine?

A
  1. Smoking cessation
  2. Self-management of chronic conditions
  3. Admission avoidance
  4. Home oxygen therapy
  5. MDT cancer care
  6. Respiratory failure
  7. Atopy
  8. The “treatment ladder” approach to asthma and COPD
  9. Management of chest drains
  10. Diagnosis and staging of lung cancer
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15
Q

What are the “top ten” respiratory medications?

A
  1. Oxygen
  2. Beta-agonists
  3. Antimuscarinics
  4. Oral and inhaled corticosteroids
  5. Combination inhalers
  6. Antihistamines
  7. Leukotriene receptor antagonists
  8. Mucolytics
  9. Monoclonal antibodies
  10. Antifibrotics
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16
Q

Topic 2

A

Performing a Patient Examination in Respiratory Medicine

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17
Q

How would you start the examination?

A

WIPER

Wash hands
Introduce yourself
Patient details (ask for at least 3)
Explain the procedure and gain consent
Risks - tell the patient if there are any

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18
Q

What would you do after WIPER?

A
  1. General inspection of the bed area e.g. inhalers, nebulisers, oxygen masks, sputum.
  2. End-of-the-bed-o-gram e.g.
  • posture: lying flat or raised?
  • colour: cyanosed?
  • respiratory rate
  • pain on breathing? pleuritic?
  • fever
  • cachexia (unintentional weight loss)
  • pursed-lipped breathing in COPD
  • nutritional state (obesity may indicate obstructive sleep apnoea or Pickwickian syndrome)
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19
Q

Inspection - what does this include?

A

Inspection of the:

  1. Hands and arms
  2. Face - general, eyes and mouth
  3. Chest
  4. Posterior chest
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20
Q

Signs of respiratory disease on inspection of the hands (and arms) ?

A

Clubbing
Tar staining
Wasting of the intrinsic muscles (a sign of T1 nerve invasion by apical lung cancer)
Fine tremor (a sign of beta-agonist use e.g. salbutamol)
Flapping asterixis (get patient to cock their wrists back, if positive = respiratory failure)
Pulse rate, rhythm, and character (e.g. bounding in CO2 retention)
Pulsus paradoxus - an exaggeration of the normal decrease in bp on inspiration (seen in severe obstructive airways disease and cardiac tamponade)
Raised JVP (suggests cor pulmonale)
A raised non-pulsatile JVP may be seen in SVC obstruction due to lung cancer - oedema will be present in the neck and face
Peripheral cyanosis

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21
Q

Signs of respiratory disease on inspection of the face?

A

Horner’s syndrome
Chemosis/ conjunctival oedema: swelling of the conjunctiva, hypercapnia secondary to COPD.
Pursed lips
Nose: beaky
Facial swelling: seen in SVC obstruction
Dental caries (may cause lung abscess)#
Central cyanosis

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22
Q

Signs of respiratory disease on inspection of the chest?

A

Shape: deformity, hyperinflation (emphysema), barrel chest
Severe kyphoscoliosis: spinal curvature that makes the spine look rounder than normal
Severe pectus excavatum (funnel chest)
Pectus carinatum (pigeon chest) +/- Harrison’s sulci
Colour
Breathlessness
Scars
Symmetry of movement
Abdominal paradox (diaphragm weakening)
Prominent veins (SVC obstruction)
Intercostal indrawing: use of accessory muscles

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23
Q

Signs of respiratory disease on inspection for symmetry?

A

Scars
Muscle wasting
Chest versus abdominal (diaphragmatic) breathing
Use of accessory muscles
Recession (common in children and adults with tracheal obstruction)

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24
Q

Signs of respiratory disease from inspection of sputum?

A

Increased volume of sputum = bronchiecstasis
Mucopurulent (infection)
Purulent (green = infection)
Haemoptysis/ bloody (cancer, pulmonary embolism, tuberculosis, bronchiecstasis)

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25
Q

What are you assessing when palpating the chest?

A

Tracheal position
(deviation occurs towards the side of the pathology in pulmonary fibrosis or collapse but away from the side of the pathology in a pneumothorax or massive effusion)
Apex beat
Assess chest expansion (normal = 3-5cm, abnormal less than 2cm). Remember to ask the patient to exhale fully before assessing expansion.
Assess tactile vocal fremitus “say 99”
Cricosternal distance
Tenderness: costochdritis, rib fracture
Liver: position (low lying), enlargement

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26
Q

What else should you palpate?

A

Lymph nodes!

Submental
Submandibular
Pre-auricular
Post-auricular
Superficial cervical
Deep cervical
Posterior cervical
Supraclavicular

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27
Q

How would you percuss the chest?

A

Starting at the apices (highest point of the lungs - protrudes above the first costal cartilage and the medial third of the clavicle)
percuss from side to side

Ensure you have percussed every lobe of the lungs.

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28
Q

What are you assessing when percussing the chest?

A

Resonant: normal
Dullness: consolidation and collapse
Stony dullness: fluid (effusion)
Hyper resonant: pneumothorax

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29
Q

How would you auscultate the chest?

A

Start at the apices, and auscultate from side to side anteriorly and laterally with open-mouthed breathing (clavicle to 6th rib, mid-clavicular line; axilla to 8th rib, mid-axillary line)

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30
Q

What are you assessing when auscultating the patient?

A

Vesicular (normal) breath sounds
Bronchial breathing
Wheeze: monophonic (single large airway obstruction) and polyphonic (narrowing of small airways)
Crackles/crepitations: coarse (consolidation, bronchiectasis)
fine, late inspiratory (pulmonary oedema, lung fibrosis)
Pleural rub
Vocal resonance
- get the patient to cough, and auscultate again, noting any changes.
- get the patient to “say 99” and auscultate again (transmission is reduced across a pleural effusion or pneumothorax)
- if you suspect an area of consolidation perform whispering pectoriloquy.

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31
Q

What do you do after auscultating the chest?

A

Repeat inspection, palpation, percussion and auscultation (spine of scapula to 11th rib) on the back with the patient sitting forward

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32
Q

How would you end the respiratory examination?

A

Palpate the cervical lymph nodes.
Palpate the ankles for oedema (right heart failure and secondary to pulmonary hypertension), look for DVT
Check sputum pot (volume, consistency, colour, odour, and haemoptysis)
Assess peak flow (state that you would do this in the OSCE)
Thank the patient and tell them to redress
Wash your hands

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33
Q

Topic 3

A

Chest x-ray interpretation

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34
Q
  1. Preliminaries
A

Patient details:
which patient, how old and when was the image taken?

X-ray details:
Posteroanterior or anteroposterior projection?
Is the patient rotated?
Is there adequate penetration?
Has the patient taken an adequate breath?

Compare to previous x-rays if available

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35
Q
  1. Trachea
A

Normal x-ray:
It should be widely patent and central in the chest.

Abnormalities: the trachea may be pulled towards areas of fibrosis or collapse. May be pushed by masses (e.g. a goitre, lymphadenopathy, large pleural effusion or a tension pneumothorax)

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36
Q
  1. Mediastinum
A

Normal x-ray:

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37
Q
  1. Heart size
A
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38
Q
  1. Diaphragm
A
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39
Q
  1. Pleura
A
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40
Q
  1. Lungs
A
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41
Q
  1. Bones
A
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42
Q
  1. Soft tissue
A
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43
Q
  1. Misc
A
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44
Q

Topic 4

A

Anatomy of the respiratory system (recap!)

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45
Q

What is the principal function of the respiratory system?

A

Extract oxygen from the external environment and to dispose of carbon dioxide

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46
Q

How is gas exchange achieved?

A

By exposing thin-walled capillaries to the alveolar gas and matching ventilation to blood flow through the pulmonary capillary bed.

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47
Q

Other functions of the pulmonary circulation?

A
  • Host defence is a key function. Large surface area of the lung being exposed to the external environment for gas exchange - dusts gases and infective agents
  • Acts as a blood pool reservoir allowing the body to respond readily to increased oxygen demands in exercise.
  • Innate immunity: de-priming neutrophils
  • speech, the passage of air through the vocal cords is necessary for phonation
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48
Q

Anatomy of the trachea

A
  • 10-12cm length
  • lies slightly to the right of the midline
  • divides at the carina into r + l main bronchi
  • carina lies under the junction of the manubrium sterni and the second right costal cartilage
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49
Q

Why is inhaled material more likely to end up in the right lung?

A

It is shorter and more vertical than the left.

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50
Q

What does the right main bronchus divide into?

A

The upper lobe bronchus and the intermediate bronchus.
The intermediate bronchus further subdivides into the middle and lower lobe bronchi.

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51
Q

What does the left main bronchus divide into?

A

The upper and lower lobe bronchi only.

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52
Q

What do each lobar bronchi further divide into?

A

Segmental and subsegmental bronchi.

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53
Q

What is the order of branching from the trachea to the alveolus?

A

Trachea > bifurcation > main bronchi > lobar bronchi > segmental bronchi > bronchi of sixth generation > terminal bronchioles > respiratory bronchioles > alveolar duct > alveolar sac > alveolus

(after sixth generation, the passageways are too narrow to be supported by the cartilage and thus are called bronchioles)

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54
Q

25 divisions in between the trachea and the alveoli.
What features do the first 7 divisions of the bronchi have?

A
  • walls consisting of cartilage and smooth muscle
  • an epithelial lining with cilia and goblet cells
  • submucosal mucus-secreting glands
  • endocrine cells
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55
Q

25 divisions in between the trachea and the alveoli.
What features do the next 16-18 divisions of the bronchi have?

A
  • no cartilage and a muscular layer that progressively becomes thinner
  • a single layer of ciliated cells but very few goblet cells
  • granulated Clara cells that produce a surfactant-like substance.
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56
Q

What is the function of ciliated epithelia?

A

Key defense mechanism.
Each cell bears approximately 200 cilia beating at about 1000 beats per min in waves of contraction. It moves mucus (containing macrophages, cell debris, bacteria, and inhaled particles) toward the larynx

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57
Q

How many alveoli does each respiratory bronchiole supply?

A

Supplies approx. 200 alveoli via the alveolar ducts.

58
Q

Anatomy of the alveoli

A
  • 300 million alveoli in each lung
  • SA: 40-80 m2
  • Epithelial lining consists mainly of type I pneumocytes
  • not completely airtight, many have holes in the alveolar
  • pores of Kohn are the interalveolar connections
  • Large alveolar macrophages are present which assist in defending the lung
59
Q

Properties of type I pneumocytes

A
  • The extremely thin layer of cytoplasm only offers a thin barrier to gas exchange.
  • Cover more of the epithelial lining than type II pneumocytes.
  • Connected by tight junctions that limit the movements of fluid in and out of the alveoli (although alveoli are not completely airtight)
  • derived from type II cells
60
Q

Properties of type II pneumocytes

A
  • More numerous than type I
  • Cover less of the epithelial lining
  • Generally found on the borders of the alveolus
  • Contain lamellar vacuoles which produce surfactant
61
Q

Anatomy of the lungs

A

Right lung:
- 3 lobes (upper, middle, and lower)
- 2 fissures (horizontal and oblique)
Left lung:
- 2 lobes (upper and lower)
- 1 fissure (oblique fissure)

62
Q

Physical signs on the right side in the front of the chest are most likely due to lesions in which lobe?

A

Upper or middle lobe because the lower lobe sits further behind in the chest.

63
Q

What is the pleura?

A

A layer of connective tissue covered by a simple squamous epithelium.

64
Q

Anatomy of the pleura

A
  • Visceral pleura (inner): covers the surface of the lung, lines the interlobar fissures, and is continuous with the parietal pleura, which lines the inside of the hemithorax.
  • Parietal pleura (outer): thicker of the two cavities and lines the pulmonary cavities.

Normal anatomy: pleurae are in apposition apart from small volume of lubricating fluid.

65
Q

Anatomy of the diaphragm

A
  • Covered by parietal pleura above and peritoneum below
  • Diaphragmatic muscle fibres arise from lower rib and insert into the central tendon.
  • Innervation (both sensory and motor): C3-C5 phrenic nerve
  • Openings: “I 8 10 eggs at 12”
    IVC at T8
    Oesophagus at T10
    Aorta and thoracic duct at T12
66
Q

Blood supply to the lungs

A

Pulmonary arteries: right ventricle > pulmonary trunk > right and left pulmonary arteries
Purpose: to deliver deoxygenated blood to the respective lungs.

Pulmonary veins: lung capillaries > 4 pulmonary veins (2 from each lung) > left atrium
Purpose: deliver oxygenated blood to the left ventricle, distributing it to the body.

67
Q

Pulmonary lymphatics

A

Location: lymphatic channels lie in the interstitial space between the alveolar cells and the capillary endothelium of the pulmonary arteries.
5 main groups of tracheobronchial lymph nodes: pulmonary, bronchopulmonary, subcarinal, superior tracheobronchial and paratracheal. These form a continuous network of nodes from the lung to the trachea.

68
Q

Innervation of the lungs

A

Parasympathetic fibres from the Vagus nerve and sympathetic fibres from the sympathetic chain accompany the PA and airways.

The autonomic nervous system is responsible for dilating and constricting the airway and for regulating bronchial secretions. Branches from the vagus nerve and sympathetic branches from the cervical cardiac nerves unite to form the pulmonary plexus. This plexus is further subdivided into anterior and posterior divisions according to its relationship with the hilum of the lung. In addition to supplying the bronchi, it also innervates the visceral pleura.
(TeachmeAnatomy)

69
Q

Topic 5

A

Physiology of the respiratory system (recap!)

70
Q

Function of the nose

A
  • To heat and moisten the air
  • To remove particulate matter

Nasal secretions contain IgA antibodies, lysozyme, and interferons. Cilia of the nasal epithelium move the mucous gel layer rapidly back to the oropharynx where it is swallowed.
Bacteria have little chance of settling in the nose. Mucociliary protection is less effective against viral infections as viruses bind to the epithelial cell receptors.

Many noxious gases such as sulphur dioxide are almost completely removed by nasal breathing.

71
Q

What is lung compliance?

A

A measure of the relationship between the retractive force of the lung and lung volume.

The lungs have an inherent elastic property that causes them to collapse away from the thoracic wall, generating a negative pressure within the pleural space.

The strength of this retractive force relates to the volume of the lung: at higher lung volumes the lung is stretched more, and a greater negative intrapleural pressure is generated.

72
Q

What is the functional residual capacity (FRC)?

A

The volume of air remaining in the lung after a quiet expiration.

73
Q

Outline the process of inspiration from FRC

A

Active process

A negative intrapleural pressure is created by:
1. the descent of the diaphragm
2. the movement of the ribs upwards and outwards (through the contraction of the intercostal muscles)

74
Q

During tidal breathing in healthy individuals, inspiration is almost entirely due to…

A

the contraction of the diaphragm.

75
Q

In addition to the descent of the diaphragm, more vigorous breathing requires…

A

the use of accessory muscles of ventilation (sternomastoid and scalene muscles).

76
Q

Outline the process of expiration

A

At rest or during low-level exercise, expiration is passive and results from the natural tendency of the lung to collapse.

77
Q

What muscles does forced expiration involve in addition to the diaphragm moving upwards and the ribs moving in and downwards?

A

Activation of the accessory muscles, these help to push the diaphragm upwards.

78
Q

Where does the control of respiration come from?

A

Motor discharges from the respiratory centre (in the brainstem) travel via the phrenic and intercostal nerves to the respiratory musculature.

79
Q

What is the main driver of respiration in healthy individuals?

A

Arterial pH.

(This is also closely related to the partial pressure of carbon dioxide in the arterial blood)

80
Q

When is breathlessness considered a symptom in patients?

A

Breathlessness oh physical exertion in normal and not considered a symptom unless the level of exertion is very light e.g. walking slowly.

81
Q

The sensation of breathlessness is derived from at least which three sources?

A
  1. Changes in lung volume, sensed by receptors in the thoracic wall muscles signalling changes in their length
  2. Tension developed by contracting muscles, sensed by Golgi tendon organs
  3. Central perception of the sense of effort
82
Q

What happens to the airways from the trachea to the periphery?

A

Decrease in size but increase in number.

83
Q

What happens to the airflow rate from the trachea to the smaller bronchioles?

A

The airflow rate is greatest at the trachea and slows progressively towards the periphery (as this is dependant on the cross-sectional area)

84
Q

What happens to the resistance to airflow from the trachea to the smaller bronchioles?

A

Resistance to airflow is highest in the trachea.
It slowly decreases from the large to small airways.

85
Q

What maintains the bronchomotor tone and what can reduce the tone (aka cause bronchodilation)?

A

Bronchomotor tone is maintained by vagal efferent nerves and can be reduced by B-adrenoreceptor agonists.

86
Q

How does airway tone show circadian rhythm?

A

Airway tone is greatest at 4am (bronchoconstriction) and lowest at midday (bronchodilation)

87
Q

How can airway tone be increased?

A

Inhaled stimuli act on epithelial nerve endings which triggers reflex bronchoconstriction via the vagus. These stimuli include cigarette smoke, solvents, inert dust and cold air.

88
Q

When are asthmatic symptoms worse and why?

A

The airways in an asthma patient are very irritable and as the circadian rhythm is the same, asthmatic symptoms are usually worse in the morning.

89
Q

What causes the movement of air through the airways?

A

Difference between atmospheric pressure and alveolar pressure.

Alveolar pressure is negative on inspiration
Alveolar pressure is positive on expiration

90
Q

In a typical normal adult at rest, pulmonary blood flow is about…

A

5 L/min

91
Q

What amount of oxygen is carried to tissues by pulmonary blood flow in a typical normal adult at rest?

A

250 ml/min

92
Q

In a typical normal adult at rest, ventilation is about…

A

6 L/min.

(This removes 200ml/min of CO2 from the body)

93
Q

What is the normal pressure of O2 and CO2 in arterial blood?

A

Arterial blood Pa02: 11-13 kPa
Arterial blood PaC02: 4.8-6.0 kPa

94
Q

What is essential for optimum gas exchange to take place?

A

There must be a match between ventilation of the alveoli (V) and perfusion (Q).

(However, in reality there is variation in the V/Q ratio in both normal and diseased lungs)

95
Q

Where are ventilation and perfusion greatest?

A

Greatest at the bases than at the apices. However, ventilation exceeds perfusion at the apices and perfusion exceeds ventilation at the bases.

96
Q

What are some causes of V/Q mismatch?

A

Direct shunting of deoxygenated blood through the lung without passing through alveoli

Areas of lung that receive no blood (e.g. anatomical deadspace , bullae and areas of under-perfusion i.e. acceleration and deceleration in aircraft or high performance cars)

97
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98
Q

Topic 6

A

Bedside tests in chest medicine

99
Q

Sputum examination

A

Collect a good sample; if necessary ask a physiotherapist to help.
Note the appearance:
1. Clear and colourless - chronic bronchitis
2. Yellow-green/brown - pulmonary infection
3. Red - haemoptysis
4. Black - smoke, coal dust
5. Frothy white/pink - pulmonary oedema

Send the sample to the lab for microscopy, culture/sensitivity. If indicated, ask for ZN stain and PCR.

100
Q

Peak expiratory flow (PEF)

A

Measured by a maximal forced expiration through a peak flow meter.

It correlates well with the forced expiratory volume in 1 second (FEV1) & is used as an estimate of airway calibre in asthma, but is effort-dependent.

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