Respiratory Flashcards
Decongestants - Sympathomimetics
Prototypes
ADRs
Alpha 1 Agonists:
Phenylephrine
Oxymetazoline
Pseudophedrine
ADRs:
topical/intranasal: rebound congestion
oral dosing:
- CV - generalized vasoconstriction - caution for pts with HTN, CAD, arrhythmias, cerebrovascular disease
- CNS - restlessness, irritability, insomina
- high abuse potential r/t CNS stimulation
1st gen antihistamines
drug names
ADRs
diphenhydramine, chlorpheniramine - “amine”
ADRs: mild
- sedation
- anticholinergic effects - dry mouth, eyes, urinary retention, tachy
- use with caution: pts with glaucoma, hyperthyroidism, HTN, BPH
-interactions:
- increased CNS effects w/ ETOH, hypnotics, antipsychotics,
anxiolytics, narcotics
- increased anticholinergic effects w/: antipsychotics, TCAs
second gen antihistamines
non-sedating
loratidine, cetirizine, fexofenadine, desloratadine, levocetirizine
intranasal - azelastine, olipatadine
histamine 1 receptor antagonists
ADRs: epistaxis, HA, bad taste, somnolence (r/t rare absorption into
systemic circulation)
do not treat the common cold - do not relieve congestion
nonopiod antitussives
drug names
ADRs
Dextromethorphan - most effective nonopioid
ADRs:
-potential for abuse at high doses r/t euphoria at high doses
-rare at therapeutic doses - light inebriation, nausea, dizziness, drowsiness
Opioid Antitussives
drug names
ADRs
Codeine and Hydrocodone
- 1/10th of dose for pain relief
- schedule V drug (codeine for pain is sch. II)
ADRs: CNS depression - sedation, OD can result in resp. depression
expectorant - prototype and education
guaifenesin (robitussin)
hydration is best expectorant
mucolytic - prototype, MOA, and ADRs
Acetylcysteine - breaks down mucus (liquefies)
via nebulizer
ADRs: foul odor, bronchospasm, n/v, runny nose, throat/lung irritation, sore mouth, stomatitis, hemoptysis
indic Chronic bronchitis, Cystic fibrosis
intranasal glucocorticoids
beclomethasone, budesonide, fluticasone, mometasone, triamcinolone
ADRs dry mucosa, burning/itching, epistaxis, sore throat & HA
2 main drug types for both asthma and COPD
Glucocorticoids - beclomethasone, prednisone
Bronchodilators - beta 2 agonists albuterol, salmeterol
other anti-inflammatory:
mast cell stabilizer
CroMolyn
prophylaxis, not quick relief - for mild, persistent asthma or exercise induced bronchospasm, + seasonal rhinitis
decreases the release of inflammatory mediators
use 15 minutes before exercise
ADRs - safest anti-asthma med
cough, bronchospasm
Leukotriene antagonist
Montelukast, Zafirlukast, zileuton (all PO)
- reduce bronchoconstriction, inflammatory response - prophylactic, not for ongoing attacks
- used in asthma maintenance
- 2nd line - when IGC cannot be used or is inadequate
- less effective than glucocorticoids
ADRs - neuropsych - depression, SI
Monoclonal Antibodies
Omalizumab
- pts >12 years with allergy related asthma, uncontrolled by GCs
- binds to igE so less can release histamine, leukotrienes
ADRs
injection site rxn - mild to anaphylaxis
For COPD only
Phosphodiesterase-4 inhibitors
Roflumilast
used in severe, chronic COPD
reduces exacerbations
inhibits PDE4 -> increases accum. of cAMP
anti-inflammatory - decrease in cytokines & inflammatory cells
maintenance - taken daily for severe/chronic COPD
no bronchodilation
ADRs: mood changes, depression, SI, weight loss, appetite loss, GI upset, diarrhea, HA, dizziness
Anticholinergic Bronchodilators
ipotropium, tiotropium - approved for COPD, very commonly used offlabel for asthma
ADRs: anticholinergic - dry mouth, pharynx irritation, x glaucoma, constipation, blurred vision, dec sweating CV events
Ipotropium
onset: 30 seconds duration: up to 6 hrs
indicated for allergy induced and EIB
*combined with Albuterol - combivent - PNS/SNS
tiotropium - LAMA - maintenance therapy for bronchospasm r/t COPD
MDI considerations
2 doses - wait 1 minute
2 different drugs? - SABA, 5 minutes, then glucocorticoid (better delivery)
spacer recommended - 21% -> lungs vs 9%