respiratory 1 Flashcards
respiration = ____, specifically…
gas exchange b/w environment and organism
specifically, the uptake of oxygen and the excretion of CO2
describe the steps of gas exchange during respiration
oxygen uptake: get oxygen from environment into lungs –> get oxygen from lung into blood –> oxygen transported to circulatory system by blood in bulk transport –> exchange b/w blood and tissues –> O2 then exchanged b/w intracellular parts of tissue and mitochondria where it is used by oxidative phosphorylation to generate ATP (that process in mitochondria produces CO2, the major toxic waste product from carbohydrate metabolism) –> starts taking reverse route to be eliminated from body, CO2 diffuses from mitochondria into tissue –> from tissue to blood –> carried in bulk transport to lung where it diffused from blood into airspace in lung –> expelled into atmosphere
list the 5 respiration events by name
1- breathing/ventilation (air from environment into lungs)
2- external respiration (exchange of gases b/w air in lungs & blood)
3- gas transport by blood (bulk transport- transport of O2 to body cells & return of CO2)
4- internal respiration (exchange gases b/w blood and body cells)
5- cellular respiration (actual use of oxygen in processes to generate ATP and production of Co2)
in general, lungs hold ___L of air, they have a huge ____…
lungs weigh ___, and at rest, contain ___ mL of blood…can hold ___mL during exercise
4L, huge surface area (75-80 sq meters)
600 grams, contain 60-140 mL of blood –> it increases during exercise, can hold up to 200 mL of blood when heart pumping blood into lungs thru exercise
structurally, lungs can be divided into 2 structural groups:
airways (upper & lower) and terminal lung sacs (alveoli)
airways of the lungs can be divided into ___ and ___, which each consist of…
upper airways: nose, sinuses, pharynx, vocal cords
lower airways: trachea, left & right bronchus, bronchioles
airways of the lung have 3 functions:
1- deliver air into deep parts of lung (into alveoli, terminal airsacs)
2- warm the air, airways give up a little bit of heat so that its as close to core body temp when in deepest parts of lungs)
3- moisturize the air (as breathe in, add a little bit of water vapor to air to prevent deep parts of lungs from drying out)
overall, the functions of the airways of the lung do what?
condition the air as it goes into lungs, they act as first line of defense to keep germ-free
describe the structural branching of the lower airways
trachea branch into left & right bronchus –> these branch into about 1 million bronchioles in the lung –> the alveoli (terminal air sacs) branch off the ends of the bronchioles (300 alveoli at the end of each bronchiole, so 300 million alveoli in lungs)
how much volume of air does the nose hold?
volume of air that goes b/w lungs per day = ___
describe nose
20 mL of air
10,000-15,000 L of air
- nose has huge surface area due to all the folds called the nasal terminae
- lots of secretory cells in nose that secrete immunoglobulins, interferons help keep the air sterile as you breathe in
- nasal cavity acts as a filter (lined with hairs), anything above 10 microns gets filtered out
- surrounding nose are sinus cavities- lined with cilia, mucus-producing cells (trap particles & clear sinus cavity)
what do the lower airways function in? what are the cell types in them?
function in defense
epithelial cells & goblet cells (5:1 ciliated cells to goblet cells)
epithelial cells of the lower airways are lined with ___ that face…
why do airway epithelial cells have their name?
cilia that face the airways
epithelial refers to position, means these cells contact air
goblet cells of the lower airways produce what?
produce and secrete mucus, mucus is only produced in patches along airways in goblet cells, then beating of cilia spreads the mucus evenly across surface of the airways (mucus traps foreign particles and the cilia beats upwardly toward throat to expel the foreign stuff)
normally mucus is fairly ___, it is produced by the transport of what ion? explain
watery, loose
produced by transport of Cl ions out of goblet cells into the paricilliary layer (Cl pulls water with it across osmotic gradient)- main Cl channel responsible is CFTR (cystic fibrosis transmembrane regulator), when it functions normally, outward movement of Cl is greater than inward movement of sodium –> more water moves out, making parcilliary layer watery and loose (gives mucus a water consistency to be easily moved by cilia)
what do the chemical compounds of cigs damage in the lower airwaud?
kill cilia and makes goblet cells stop producing mucus, it damages the first line of defense in trachea, more irritation