Respiration Flashcards
Define compliance
A measure of the lungs ability to stretch and expand
How does the value of airway resistance differ in healthy subjects compared with those with COPD?
Normal - 0.5 - 2.0
COPD - 5.0 (small airways = 70%)
Define airway resistance
The opposition of flow caused by forces of friction
Define laminar flow
Particles passing any point have the same speed and direction
Which airways have laminar flow
Trachea and bronchi
Define turbulent flow
The average velocity passes a critical value causing vortices to develop, increasing the resistance to flow
Which airways have turbulent flow
Bronchioles
What does a Reynolds number of less than 1000 indicate
Laminar flow
What does a Reynolds number of more than 1500 indicate
Turbulent flow
What is Reynolds equation?
Re=2dvp/n (d = diameter, v = velocity, p = density of gas, n = viscosity)
What are the factors that effect airway resistance?
Nervous factors, chemical factors, humoral factors and mechanical factors
How do nervous factors effect airway resistance?
Contribute to bronchial tone. In the parasympathetic NS the vagus nerve releases ACh which binds to M3 receptors. In the sympathetic NS NE is a weak agonist to B2 adrenergic receptors that leads to dilation and decreased glandular secretions via cAMP.
Which drug blocks the bronchoconstriction caused by the binding of ACh to M3 receptors?
Atropine
What are the chemical factors that effect airway resistance?
Endogenous (histamine, adrenaline, leukatrines, PACO2) and exogenous (B2 agonists and muscarinics)
What are the humoral factors that effect airway resistance?
Epinephrine - released from the medulla and more potent than NE
Leukotrienes LTC4 and LTD4 are more potent than epinephrine
How do Ptm, Ptp, Pip and Pa change during inspiration?
All values of Ptm increase but these begin to decrease down the airways, Pa decreases and also decreases down the airways, Pip decreases
How do Ptm, Ptp, Pip and Pa change during expiration?
Ptm decreases but these values increase down the airways. Pa increases and increases down the airways. Pip increases.
Describe what happens to the airways in Emphysema
There is a loss of elastic tissue and the alveolar walls break down, the tethering between adjoining air spaces is reduced. This leads to the airways becoming flimsy therefore they are less likely to resist collapse during expiration and the compression of the airways becomes exaggerated.