RESP TBL

Question 1

Dysregulation of which cell type is most associated with interstitial lung disease?

Answer 1

Fibroblasts

Question 2

A 67-year old man with COPD is admitted to hospital with an exacerbation. They have had a fever and coughing for 2 days, and their lung function has declined. What is the most likely cause?
A: streptococcus pneumoniae
B: allergen exposure
C: rhinovirus
D: influenza A virus

Answer 2

Rhinovirus

Question 3

4. What class of drugs is commonly used in the treatment of chronic hypersensitivity pneumonitis but harmful in idiopathic pulmonary fibrosis?
   A: corticosteroids
   B: anti-fibrotics
   C: non-steroidal immunosuppressants
   D: immune modulators

Answer 3

Corticosteroids

Question 4

Mr DE is a 68-year old with an existing diagnosis of idiopathic pulmonary fibrosis. They have developed a fever, persistent cough and are breathless. Mr DE’s wife take him to see their GP complaining that Mr DE has also had difficulty remembering things for the last few days, The GP is concerned they may have pneumonia. Mr DE’s breathing rate is 28 breaths per minute, his pulse is 64 beats per minute, his temperature is 38.5 degrees C, systolic pressure is 100 mm Hg, diastolic pressure is 55 mm Hg. After assessment the GP refers Mr DE directly to hospital. How would you grade Mr DE’s pneumonia?

Answer 4

Grade 3. CRB-65: confusion = 1, resp (28<30) = 0, blood pressure (55<60) = 1, age = 68 = 1 therefore 3 points

Question 5

A novel zoonotic influenza A virus originating in birds begins to circulate in humans. It has a unique H10N7, where the hemogluttinin can bind alpha-2,6 sialic acid. Defects in which part of the immune response would you be most concerned would results in more severe disease in individuals infected with this novel virus?
A: interferons
B: T cells
C: antibodies
D: neutrophils

Answer 5

Interferons

Question 6

The annual influenza vaccine is modified to incorporate the new H10N7 strain of influenza A virus, and the population is vaccinated. In the context of a vaccinated population, defects in what part of the immune response would you be most concerned might result in more severe disease?

Answer 6

Antibodies