RESP PHARMACOLOGY

Question 1

Respiratory drug nomenclature

Answer 1

…mab = monoclonal antibody (e.g Reslizumab)
…sone = corticosteroid (e.g Dexamethasone)
…lone = corticosteroid (e.g Prednisolone)
…terol = bronchodilators (e.g Salmeterol)
…nib = kinase inhibitor (e.g Nintedanib

Question 2

What are the 2 vital regions of the airways

Answer 2

Conducting airways which are superior

Respiratory region which is inferior - consists of respiratory bronchioles, alveolar ducts and alveolar sacs

Question 3

What are targets for drugs in resp disease?

Answer 3

Fibrosis - target fibroblasts,
Inflammation - immune cells
Infection - microorganisms
Cough - mucus, goblet cells
Allergy - mast cells, eosinophils, immune cells
Bronchiectasis - airway smooth muscle cells
Bronchoconstriction - airway smooth muscle cells
Cancer - neoplasms

Overlap between these components

Question 4

Inhaled pharmacologic

Answer 4

Inhaled medicines delivered directly to lung via oral or nasal route

1. Inhaler devices allow drugs to penetrate deep into the lung and to achieve the correct dose.
   Inhalers deliver dry powder formulation.
   Most common device
2. Nebulisers deliver medication in the form
   of aerosols

Question 5

Transepithelial transport of the drugs along resp epithelium is what?

Answer 5

from conducting airways and resp region is sinificantly different

Question 6

Conducting airways features

Answer 6

smaller surface area and lower regional blood flow.

High filtering capacity (mucus, cilia) removes up to 90% of delivered drug particles

Question 7

Respiratory region features:

Answer 7

accounts for more than 95% of the lung’s surface area and is directly connected to the systemic circulation via the pulmonary circulation