Resp Pharma Flashcards
Examples of short acting beta agonists
Salbutamol
Terbutaline
Long acting beta agonists
Formeterol
Salmeterol
Action of beta agonists
Increase cAMP in smooth muscle cells
Leading to dilation
Beta agonists metabolism and excretion
Liver
Urine
Beta agonists side effects
Tremor Headache Palpitations Tachycardia GI upset Hypokalaemia
Example short acting antimuscarinic
Ipratropium
Example long acting muscarinic
Tiotropium
Mechanism of antimuscarinics
Decrease cGMP
Causes decreased SMC contractility
Metabolism and excretion of antimuscarinics
Partially metabolised in liver
Excreted in urine
Examples of xanthines
Aminophylline
Theophylline
Mechanisms of xanthines
Block phosphodiesterase
less cAMP breakdown
Bronchodilation
Metabolism and excretion of xanthines
Liver
Urine
Side effects of xanthines
Headache GI upset Reflux Palpitations Dizziness
Inhaled glucocorticoids examples
Beclomethosone
Budesonide
Fluticasone
Action of glucocorticoids
Decrease bronchial inflammation
Modify allergic reactions
Metabolism and excretion of glucocorticoids
Liver
Urine
Side effects of glucocorticoids
Cough
Thrush
Taste changes
Hoarseness
Oral/IV glucocorticoids
Prednisolone
Hydrocortisone
Dexamethosone
Triamcinolone
Mechanism of non inhaled glucocorticoids
Altered gene transcription
Metabolism and excretion of glucocorticoids
Liver
Urine
Side effects of glucocorticoids
Adrenal suppression Hyperglycaemia Psychosis Insomnia Indigestion Mood swings
