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Resp Path > Resp Pharma > Flashcards

Resp Pharma Flashcards

0
Q 
G class of alpha-2
Function ?
A

Gi

LIPSSA - pre+post synaptic

Decrease lipolysis
Decrease insulin release
Increase platelet aggregation
Decrease sympathetic outflow/ NA release
Increase SM contraction @ vessel
Increase aqueous humour production
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1
Q 
G class of alpha-1 
Function ?
A

Gq

Vladimir Putin sucks gay KOK

Vascular SM contraction
Pupillary dilator = Mydriasis = contract radial muscle
Sphincter muscle of GI + detrusor Contract
Glycogenosis @liver
K+ release from liver and salivary gland

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2
Q 
G class of beta-1 
Function ?
A

Gs

P’SHN CARL POST SYNAPTIC

Increased Platelet aggregation
Increased non-Sphincter part of GI = relaxation
Increased Heart rate
Increased NA release
Increased contractility
Increased Alvelais from saliva reblends
Increased renin release
Increased Lipolysis
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3
Q 
G class of beta-2
Function ?
A

Gs

CIV. GASH @ CLUB

Increased contractility and heart rate
Increased insulin release
Vasodilation

Glycogenlysis
increased Aqueous humour production
Smooth-muscle relaxation detrusor
decreased Histamine release

Ciliary muscle relax
Lipolysis
decreased Uterine tone– Tocolysis
Bronchodilation

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4
Q 
G class of histamine-1 + 2
Function ?
A

Gq

Bronchoconstriction,
Vasodilation
Vascular permeability,
nasal and bronchial mucus production
pruritus pain

H2 = gastric acid secretion

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5
Q

Which sympathicomimetic Beta >alpha?

Function?

A

Epinephrine

Glaucoma open-angle
Anaphylaxis
Asthma
Hypotension

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6
Q

Which sympathicomimetic Alpha-1 >alpha-2 >beta-1

Function?

A

Norepinephrine

Hypotension:

Alpha-1 mediated vasoconstriction – >
Increase systolic and diastolic pressures– >
Increased MAP – > Bradycardia

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7
Q

Which sympathicomimetic Beta1 = beta2?

Function?

A

Isoproterenol

Electrophysiologic evaluation of tachyarrhythmias
Worse ischaemia

Beta-2 mediated vasodilation – >
reduce MAP +Increase HR

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8
Q

Which sympathicomimetic D1=D2> beta >alpha?

Function?

A

Dopamine

Bradycardia, heart failure, shock

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9
Q

Which sympathicomimetic Beta1 > beta2+alpha?

Function?

A

Dobutamine

Heart failure + cardiac stress test

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10
Q

Which sympathicomimetic alpha1 >alpha2?

Function?

A

Phenylephrine Pseudoephedrine

alpha agonist

Ocular procedures – mydriatic
open obstructed eustachian Tubes
Hyperaemia reduce + Hypotension (vasoconstrictOR)
Edema
Nasal decongestant – rhinitis
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11
Q

Give to sympatholytic/alpha-2 agonists

Give functions + toxicities

A

Clonidine – hypertensive emergency, ADHD, pain

Alpha methyldopa HTN @Pregnancy

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12
Q

Patient has pheochromocytoma and is going to have an operation what drug would you give and what is this to prevent?

A

Phenoxybenzamine to prevent catecholamine hypertensive crisis

Problems =
ortho static hypotension + reflex tachycardia

Non-selective irreversible alpha blocker

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13
Q

Patient is an MAO inhibitors and eats tyramine containing foods

A

Phentolamine reversible non-selective alpha blocker

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14
Q
  1. Patient has BPH urinary symptoms
  2. Patient has PTSD
  3. Patient has hypertension

What would you give me

A
  1. Prazo/Terazo/Tamsulo/Doxazo SIN
  2. Prazosin
  3. Prazo/Terazo/Doxazo SIN

Alpha-1 selectives

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15
Q

Patient is depressed what do you give them?

A

Mirtazapine alpha2 selective

16
Q

Patients has an allergy
Patient has motion sickness
Patient has a sleeping problem

What do you give me?

A

First generation H1 blocker

Diphenhydramine/dimenhydrinate/Chlorpheniramine

Problems = sedation

17
Q

Patient has an allergy What do you give them

A

Is second generation H1 blocker

Loratadine fexofenadine desloratadine Cetirizine

18
Q

Give to expectorant’s and their functions

A

Guaifenesin – seems respiratory secretion

N-acetylcysteine –
Mucolytic = loosen mucus plug @CF by disrupting disulphide bonds
Paracetamol overdose

19
Q

Give three pulmonary hypertension drugs

A

PDE – 5 inhibitors e.g. sildenafil
Endothelin receptor antagonists e.g. bosentan
Prostacyclin analogues e.g. epoprostenol/iloprost

20
Q

What do endothelin receptor antagonists do

A

Dcrease The vascular resistance

21
Q

What do you PDE 5 inhibitors do

A

Inhibit cGMP PDE5 + Prolong dilatory effect of NO

22
Q

What do prostacyclin analogues do

A

Vasodilatory effect on pulmonary/systemic arteries

Inhibit platelet aggregation

Resp Path (10 decks)

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