Resp. Immunology Flashcards
What is Kostmann Syndrome?
Rare autosomal recessive disorder (congenital Neutropenia). Typically presents as recurrent infections 2 weeks after birth.
What is Leukocyte Adhesion Deficiency?
Rare primary immune deficiency where neutrophils fail to being to endothelial markers and so the neutrophils cannot find where the infection is. It is a genetic defect in CD18.
What is Chronic Granulomatous Disease?
failure of oxidative killing due to an inability to generate oxygen free radicals.
What are SPUR infections?
Serious, Persistent, Unusual, Recurrent. They indicate immune deficiency.
What is SCID?
Severe combined immunodeficiency. It is a failure to produce lymphocytes.
What is DiGeorge Syndrome?
in short: failed development of the thymus.
What is Hypogammaglobulinaemia?
it is a failure to produce mature B-Cells.
What is common variable immunodeficiency?
Low IgG, IgA, IgE. This leads to recurrent infections (often autoimmune).
What is an Allergy?
it is an IgE-mediated response to an external antigen.
Describe the Hygiene Hypothesis.
it is when a decrease in infectious exposure during early childhood/ life predisposes a person to increased sensitivity (predisposition to allergic stimuli).
