resp Flashcards
prophylactic Abx used in COPD
marcolides (azithromycin)
what does A1AT increase the risk of?
hepatocellular carcinoma
Management of acute bronchitis
oral doxycycline (if NOT pregnant- if pregnant use amoxicillin)
COPD- if the patient has raised eosinophils (regardless of FEV1) what therapy should be commenced?
ICS
most common organism causing infective exacerbations of COPD
Haemophilus influenzae
what are blue bloaters/ pink puffers?
blue bloater= chronic bronchitis
pink puffer= emphysema
diagnosis of COPD
spirometry- obstructive patter:
FEV1/FVC= 0.7
no change on reversibility testing
treatment pathway in COPD (non-acute management)
lifestyle- stop smoking, flu vaccinations
1- SABA (salbutamol/ terbutaline) or SAMA (ipratropium bromide)
2- if no asthmatic features= LABA (formeterol) + LAMA (tiotropium bromide)
- if asthmatic features (or raised eosinophils)= LABA + ICS
management of an acute COPD exacerbation
- nebulised bronchodilators (salbutamol an ipratropium)
- 02 sats 88-92%
- prednisolone
- ABx if infection
what is cor pulmonale?
right sided heart failure caused by chronic pulmonary arterial hypertension
commonly caused by COPD
clinical features of cor pulmonale
dyspnoea, fatigue, syncope
cyanosis, tachycardia, raised JVP
tricuspid regurgitation (pansystolic murmur)
what organs does A1AT affect?
lungs (bronchiectasis and emphysema- think breakdown of elastase)
liver (cirrhosis)
diagnosis of A1AT
low serum A1AT
liver biopsy- acid-Schiff-positive staining globules
pulmonary function tests- obstructive lung disease pattern and causes
FEV1 reduced
FVC reduced/ normal
FEV1/FVC ratio <0.7
causes:
- asthma
- COPD
- bronchiectasis
pulmonary function tests- restrictive lung disease pattern and causes
FEV1 reduced
FVC significantly reduced
FEV1/ FVC= normal/ increased
causes:
Pulmonary fibrosis
Asbestosis
Sarcoidosis
Acute respiratory distress syndrome
Infant respiratory distress syndrome
Kyphoscoliosis e.g. ankylosing spondylitis
Neuromuscular disorders
Severe obesity
what is sarcoidosis?
multisystem granulomatous disorder