resp Flashcards

1
Q

prophylactic Abx used in COPD

A

marcolides (azithromycin)

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2
Q

what does A1AT increase the risk of?

A

hepatocellular carcinoma

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3
Q

Management of acute bronchitis

A

oral doxycycline (if NOT pregnant- if pregnant use amoxicillin)

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4
Q

COPD- if the patient has raised eosinophils (regardless of FEV1) what therapy should be commenced?

A

ICS

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5
Q

most common organism causing infective exacerbations of COPD

A

Haemophilus influenzae

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6
Q

what are blue bloaters/ pink puffers?

A

blue bloater= chronic bronchitis

pink puffer= emphysema

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7
Q

diagnosis of COPD

A

spirometry- obstructive patter:
FEV1/FVC= 0.7

no change on reversibility testing

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8
Q

treatment pathway in COPD (non-acute management)

A

lifestyle- stop smoking, flu vaccinations

1- SABA (salbutamol/ terbutaline) or SAMA (ipratropium bromide)

2- if no asthmatic features= LABA (formeterol) + LAMA (tiotropium bromide)

  • if asthmatic features (or raised eosinophils)= LABA + ICS
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9
Q

management of an acute COPD exacerbation

A
  • nebulised bronchodilators (salbutamol an ipratropium)
  • 02 sats 88-92%
  • prednisolone
  • ABx if infection
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10
Q

what is cor pulmonale?

A

right sided heart failure caused by chronic pulmonary arterial hypertension
commonly caused by COPD

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11
Q

clinical features of cor pulmonale

A

dyspnoea, fatigue, syncope
cyanosis, tachycardia, raised JVP
tricuspid regurgitation (pansystolic murmur)

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12
Q

what organs does A1AT affect?

A

lungs (bronchiectasis and emphysema- think breakdown of elastase)

liver (cirrhosis)

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13
Q

diagnosis of A1AT

A

low serum A1AT
liver biopsy- acid-Schiff-positive staining globules

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14
Q

pulmonary function tests- obstructive lung disease pattern and causes

A

FEV1 reduced
FVC reduced/ normal
FEV1/FVC ratio <0.7

causes:
- asthma
- COPD
- bronchiectasis

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15
Q

pulmonary function tests- restrictive lung disease pattern and causes

A

FEV1 reduced
FVC significantly reduced
FEV1/ FVC= normal/ increased

causes:
Pulmonary fibrosis
Asbestosis
Sarcoidosis
Acute respiratory distress syndrome
Infant respiratory distress syndrome
Kyphoscoliosis e.g. ankylosing spondylitis
Neuromuscular disorders
Severe obesity

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16
Q

what is sarcoidosis?

A

multisystem granulomatous disorder

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17
Q

presentation of sarcoidosis

A

lungs- mediastinal lymphadenopathy, pulmonary fibrosis, pulmonary nodules

systemic- fever, fatigue, weight loss

liver- nodules, cirrhosis, cholestasis

eyes- conjunctivitis, uveitis, optic neuritis

skin- erythema nodosum

18
Q

sarcoidosis- bloods

A

hypercalcaemia
raised serum ACE
raised CRP

19
Q

Sarcoidosis- CXR

A

hilar lymphadenopathy

20
Q

sarcoidosis- gold standard investigation

A

histology- biopsy via bronchoscopy

21
Q

sarcoidosis- treatment

A

only if symptomatic/ eye involvement

long term prednisolone (prescribe bisphosphonates alongside to protect bones)

methotrexate/ azathioprine second line

22
Q

Describe a tension pneumothorax

A

Tension pneumothorax is caused by trauma to the chest wall that creates a one-way valve that lets air in but not out of the pleural space. The one-way valve means that during inspiration air is drawn into the pleural space and during expiration, the air is trapped in the pleural space. Therefore, more air keeps getting drawn into the pleural space with each breath and cannot escape. This is dangerous as it creates pressure inside the thorax that will push the mediastinum across, kink the big vessels in the mediastinum and cause cardiorespiratory arrest.

23
Q

presentation of a tension pneumothorax

A

Tracheal deviation away from side of the pneumothorax
Reduced air entry on the affected side
Increased resonance to percussion on the affected side
Tachycardia
Hypotension

24
Q

management of a tension pneumothorax

A

Insert a large bore cannula into the second intercostal space in the midclavicular line

25
Q

idiopathic pulmonary fibrosis- medications to slow progression

A

Pirfenidone is an antifibrotic and anti-inflammatory
Nintedanib is a monoclonal antibody targeting tyrosine kinase

26
Q

most common cause of community acquired pneumonia

A

Streptococcus Pneumoniae.

27
Q

side effects of TB treatment- rifampicin

A

red/orange discolouration of secretions like urine and tears.

28
Q

side effects of TB treatment- isonizaid

A

peripheral neuropathy

29
Q

side effects of TB treatment- pyrazinamide

A

hyperuricaemia (high uric acid levels) resulting in gout

30
Q

side effects of TB treatment- ethambutol

A

colour blindness and reduced visual acuity

31
Q

pneumonia- most common causative organism in COPD patients?

A

haemophilus influenzae

32
Q

pneumonia- most common causative organism post- influenza infection

A

staph aureus

33
Q

pneumonia- what is seen on the bloods of a patient with legionella pneumonia?

A

hyponatraemia
lymphopenia

34
Q

pneumonia- most common causative organism in alcoholics

A

klebisella pneumoniae

35
Q

pneumonia- most common causative organism in HIV patients

A

pneumocystitis jiroveci

36
Q

describe CURB 65

A

Confusion (AMT <8/10)
Urea >7mmol/l
respiratory rate > 30
BP- systolic <90 or diastolic <60
65- age over

37
Q

management of low and moderate/ high severity CAP?

A

low:
amoxicillin- oral, 5 days
use a macrolide or tetracycline if penecillin allergy

moderate/high:
amoxicillin and macrolide for 7-10 days

38
Q

how is pneumocystitis jiroveci pneumonia treated?

A

co-trimoxazole

39
Q

in patients with COPD with a confirmed diagnosis of pneumonia, what should be co-prescribed alongside antibiotics?

A

prednisolone

40
Q

what investigation is done and when in all confirmed pneumonia cases post-resolution?

A

CXR at 6 weeks

41
Q

management of an unprovoked PE

A

6 months DOAC

42
Q

What type of lung cancer would cause hyponatraemia?

A

SIADH is a paraneoplastic feature of small-cell lung cancer