resp Flashcards
features of asthma?
wheeze ±dry cough atopy/allergen sensitisation reversible airway obstructiom airway inflammation - eosinophils , type 2 lymphocytes
pathogenesis of asthma?
bronchial epithelium exposed allergen eg mild → inflammation → SM hypertrophy , ↑ ECM → airway remodelling
immune response ion asthma?
antigen presented to MHC II on APC → Th0 bind → Th2 → IL 4, 13, 5 → VCAM1 expression, ↑mast cells, IGE synthesis, mucin secretion, eosinophilic airway inflammation
how is allergic sensitaization tested for in asthma?
blood tests for specific IgE antibodies to allergens of interest
total IgE not sufficient
tests for eosinophilia?
blood eosinophil ≥300
sputum eosiniphil ≥2.5%
exhaled nitric oxide
what is FeNO used for?
asthma diagnosis
steroid responsiveness prediction
corticosteroid adherence
objective tests for asthma?
airway obstructi9on on spirometry - FEV1/FVC <0.7
reversible airway obstruction - bronchodilator , ≥12%
exhaled NO , ≥35 child, ≥40 adult
asthma management?
- ↓ inflammation - inhaled corticosteroids , leukotriene receptor antagonists
- acute relief - beta 2 agonists, anticholinergics (smooth muscle relaxation)
- severe asthma - anti-IgE antibody , anti-IL5 antibody / anti-IL5 receptor antibody
how do corticosteroids work?
↓ xcytokines ↓ eosinophils ↓ macrophages , dendritic cells ↓ leak from endothelial cells ↑ b2 receptors in SM ↓mucus secretion
most important of asthma management?
adherence to ICS
why do children with asthma often have prolonged illnesses?
↓ IFN a, B y → reduced antiviral responses
how does anti-IgE antibody therapy work?
binds to circulating IgE → cannot activate mast cells cells and basophils → stop allergic cascade
reduces IgE production over time
anti-IgE antibody?
omalizumab
indicati9ons for omalizumab?
severe persistent IgE asthma ≥6yrs old
4 or more oral corticosteroids in past year
documented compliance
serum IgE 30-1500
anti-IL5 antibody?
mepolizumab
function of IL5?
regulates growth recruitment activation and survival of eosinophils
mepolizumab indications?
severe eosinophilic asthma
blood eosinophils ≥300
4+ exacerbations requiring oral corticosteroids in past year
risk factors for lung cancer?
75-90
M≥F
lower SES
smoking
non smoking causes of cancer?
asbestos radon indoor cooking fumes chronic lung diseases eg copd, fibrosis immunodeficiency familial
4 types of lung cancer?
adenocarcinoma - peripheral, mucous tissue
squamous cell carcinoma - central, bronchial epithelium
large cell cancer
small cell cancer - pulmonary neuroendocrine cells
lung cancer oncogenes?
EGFR tyrosine kinase - adenocarcinoma, women, asian, never smoekrs
ALK tyrosine kinase & cROS1 receptor tyrosine kinase - NSCLC , young patients, never smokers
BRAF 1 - NSCLC, smokers !!
symptoms of lung cancer?
wt loss cough breathlessness fatigue chest pain haemoptysis or asymptomatic
features of advanced / metastatic lung cancer?
bone fain seizures , focal weakness clubbing hypercalacemia hyponatraime cushings horners syndrome pembertons sign (obstructed SVC) cachexia
imaging options for lung cancer?
chest XR
CT abdo chest for staging
PET scan for occult metastases
methods of biopsy for lung cancer>
central tumours - bronchoscopy
staging - endo-bronchial US and trasnbrocnhial needle aspiration of mediating lymph nodes
peripheral - CT guided lung biopsy
what’s used to determine patient fitness in lung cancer>
WHO performance status 0 -asymptomatic 1 - symptomatic but ambulatory 2 - symptomatic ≤50% day in bed 3- symptomatic ≥50% day in bed 4 - bedbound 5- death
radical treatment for 0-2
surgical management for lung cancer?
early stage disease standard care
lobectomy + lymphadenectomy
sublunar resection if stage 1
radical radiotherapy for lung cancer?
alt to surgery for early stage especially if comorbidity
stereotactic ablative body radiotherapy
systemic treatments for lung cancer?
oncogene-directed - metastatic NSCLC with mutation
immunotherapy - metastatic NSCLC with no mutation and PDL1 ≥50%
cytotoxic chemo - metastatic NSCLC with no mutation and PDL1 ≤50% (+immunotherapy)
treatment for metastatic NSCLC with mutation? example?
oncogene directed (EGFR, ALK, ROS-1) erlotinib, crizotinib (tyrosine kinase inhibitors)
treatment for metastatic NSCLC with no mutation and PDL1 ≥50↓? example
immunotherapy eg pembro/atezo lizumab