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Resistance and Problems > Resistance and Problems > Flashcards

Resistance and Problems Flashcards

1
Q

Production of coagulase

A

S. aureus

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2
Q

Production of glycocalyx

A

Coagulase negative staph

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3
Q

Antiphagocytic capsule

A

S. pneumoniae

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4
Q

Dextrans (heart valve damage)

A

Viridans

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5
Q

RHO GTPase inhibitors

A

C. difficile

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6
Q

GNR resistant to penicillin, cephalosporin, and erythromycin

A

Pseudomonas

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7
Q

Gram Negative anaerobe causing abdominal infections but usually part of normal flora

A

B. fragilis

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8
Q

Production of M protein

A

Pyogenes

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9
Q

Antigenically distinct pili

A

Gonorrhea

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10
Q

Lack of cell wall

A

Mycoplasma

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11
Q

Intracellular

A

Chlamydia

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12
Q

VanA

A

Vancomycin resistance
Plasmid
Enterococci is main bacteria (faecium common)

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13
Q

Erm

A

Macrolide resistance
Dimethylation of rRNA –> can’t bind ribosome
Inducible or constitutive: erythromycin resistant if inducible, clidamycin as well if constitutive
Inducible if (+) D test: still sensitive to clindamycin

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14
Q

GyrA mutation

A

Fluoroquinolones

Accumulation of point mutations

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15
Q

KPC and NDM-1

A

Cephalexin and carbapenems
K. pneumoniae (rare) and E. coli (super rare)
Found on plasmids

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16
Q

TEM-1

A

Amoxicillin

17
Q

mecA

A

Alter PBP to PBP2a confers resistance to pencillin and cephalosporin

18
Q

bla gene

A

Resistance to penicillin found in all staph

Led to development of ampicillin

19
Q

How many strep have beta lactamase

A

0%. Resistance via altered PBP

20
Q

E. faecium vs E. faecalis beta lactam resistance

A

E. faecium - mutation/overexpression of PBP5

E. faecalis - beta lactamase on plasmid (rare)

21
Q

Pseudomonas resistance to FluoroQs

A

Efflux and altered target site

22
Q

Pseudomonas resistance to beta lactams

A

Decreased entry

23
Q

K. pneumonia resistance

A

SHV-1 chromosomal genes

Penicillin, amp/amox resistance

24
Q

ampC

A 
Enterobacter (all) and psuedomonas (all)
Chromosomal gene
Inducible or constitutive
Resistant to penicillin and cefazolin 
If constitutive, also resistant to cephtriaxone
Should use carbepenems

Resistance and Problems (1 decks)

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