Reptile Medicine Flashcards

0
Q

What is the vagovagal reflex?

A

Applying pressure to the eyes can lead to a reduction in the heart rate and response to external stimulation

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1
Q

How should a reptile appear when you are examining it on the table

A

Lizards should be bright alert and lifting their bodies off the table. Snakes should impart a feeling of strength when handled and be able to grip the sides of the table. Observe for mobility, ability to maintain a normal stance, alertness, eyes should be bright and open in lizards and clear in snakes. respiration should be noticeable but without exertion.

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2
Q

Describe the clinical examination of chelonians

A

Start at the front and work backwards. Check for head abrasions, beak eformities, A dremmel too can be used to correct these. Check ear drums and eyes for swellings. Check shell for any loose scutes, fractures, erosions, reddening and compressibility. Palpate the pre femoral fssa. You may feel eggs or bladder stones.

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3
Q

Describe the clinical examination of lizards

A

Check the eyes for any ulceration, coonjunctivitis, oedema, exudates. Check the nares and mouth for any discharges or swellings. Wait for a breath and observe the movement of the glottis and listen for any noise. Assess the effort required to open the mouth. check the teeth for any damage or infection. Check the skin for any areas of dysecdysis, swellings, parasites, scars, wouds, retained secretions. Check al limbs for trauma, normal range of movement and obvious swellings. Check cloaca and tail for any signs of damage or prolapses. In larger lizards cloacal palpation of the kidneys is possible. Palpate along the length of the coloemoic cavity. Cardiac function is best assessed using a doppler probe.

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4
Q

What should the hospitalisation environment of a reptile be like?

A

Use shredded paper as a substrate as it can be easily leaned and faecal and urinary output can be meaasured. There is no need to offer water, just bathe daily or provide fluids via stomach tube. Wear disposable gloves when handling.

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5
Q

What are the zoonotic risks with handling reptiles?

A

There is a risk of zoonotic diseases being spread to staff. Salmonella species are the most common. Most reptiles (particularly fresh water species) will be shedding salmonella or campylobacter. Testing faecal samples is of little use as faecal excretion is intermittent. This rarely cause clinical disease in reptiles.

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6
Q

Describe fluid therapy which should be given to reptiles

A

Fluid maintenance requirements are 30mls/kg per day. You can give approximately 1% of bodyweight at any given time. Fluids can be given by a variety of routes. Through bathing, oral, Intra coelomic, intraosseous, IV. The most useful are intra coelomic fluids, bathing, stomach tubing.

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7
Q

What fluids should be used in reptiles?

A

Administration of lower osmolarity fluids is recommended by some clinicians (diluted 1:10 with sterile water for injection). Practically the use of mammalian preparations is fine.

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8
Q

What is refeeding syndrome?

A

Sick reptiles require fluid, electrolytes and energy. although there may be elevated plasma electrolytes there is infact a total body deficit. Cellular ion concentration is reduced due to the lack of concurrent transport when glucose and ions are absorbed into the clls. Providing energy sources before body electrolytes are replaced can lead to a life threatening reduction in palsma electrolytes. This in particular leads to hypokalaemia and hypophosphataemia. We should aim to return the osmolarity of the reptile back to within the normal rage anticipated for that species, taking into account the seasonal effects in differing species. Terrestrial chelonians have elevated osmolarity just after hiberation, lizards have elevated values in the dry period. Fresh water aquatic species have reduced osmolarity just after hibernation. They do this by altering blood electrolyte levels. Sodium and urea values can give a good indication of hydration status and osmolarity. Aim to keep sodium below 1400mmool/L. well hydrated chelonians have a urea value of less than 2.1 mmol/l. Individuals with values up to 20mmol/L have responded to bathing aloone.

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9
Q

What are the recommendations for administering fluids and electrolytes?

A

Use standard mammalian solutions up to 3% body weight per day by the epicoelomic route. Stomach tube with water 1% body weight two or three times daily. Bathe twice a day in water for 20 minutes. Start adding electrolytes to fluids used for stomach tubing and bathing after 24 hours. Once successfully rehydrated the tortoise will start producing urine. At this stage supportive nutrition can begin as the risk of refeeding syndrome will be reduced. Up to 1% of bodyweight can be given by stomach tube of commercially formulated preparations. Keep the reptile warm before and after tubing to allow it to digest its meal.

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10
Q

How can your reptile patient be monitored?

A

Weight change is one of the most useful parameters to measure. Weight increases will initially be dramatic as the reptile changes from empty to full. Once rehydrated and with a bowel full of food , the output = input and the weight will stabilise. It is this weight that should be maintained once returned home and off supportive care. Further dramatic weight gains are not going to happen. The tortoise fills its bladder with fluid ) changes can be up to 25% of bodyweight) soo tortoise weight changes can be dramatic. Monitoring urine output and its SG and pH are useful guidelines to the metabolic state of a chelonian. A bladder aspirate can be taken if you are impatient. Aim for a pH of 7.5 and a SG of 1.003-1.012 in herbivorous terrestrial chelonians. Fresh water species will have a lower SG and if omnivorous a pH of 6.5. Dehydrated chelonians may have a SG up to 1.034.

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11
Q

Why can faecal burdens build up quickly in reptiles?

A

Reptiles generally inhabit the same environment for their lifetime. this is likely to be a small area. They are messy feeders and contaminate their food sources with faecal material. Heavy parasite burdens can build up quickly in captive reptiles as may parasites have a direct life cycle. Invertebrates if left in the tank run about and contaminate themselves with faecal material prior to ingestion.

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12
Q

How can you reduce parasite burdens in reptile

A

Provide an easy to clean substate that allows removal of all faecal material. remove all uneaten food promptly after feeding. Run a faecal sample to check for parasites. Parasites can build up on a particulate substrates and a complete substrate change may be required. Ensure all reptiles have a negative faecal sample prior to going onto particulate substrates. Monitor faecal samples at least anually to check for the need for anti parasitic drugs.

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13
Q

Why should you not worm reptiles routinely?

A

Toxic effects of deworming products are becoming well known. febendazole toxicity causes radiomimetic lesions with ulcerated, haemorrhagic bowels, Ivermectins kill chelonians as they enter the CNS and cause flaccid paralysis. Efficiency is actually increased by dosing over a few days.

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14
Q

What techniques can be used for faecal analysis?

A

Wet preparation - for motility and general impression of numbers evident. Floatation - to identify smaller numbers of parasites. Concentrate -to identify even smaller numbers. Quantification via mcmasters technique. tog et an egg cout. Iodine stained preparation for parasitic cysts. Generally the first three are sufficient. If no sample - can use a cloacal flush of 1% bodyweight of warmed saline. In some squamates manipulation will induce the passing of a faecal sample. This is preferable as it is more cocentrated. Pass catheter into colon and slowly infuse saline. Draw back on syringe and collect sample and anything else voided afterwards.

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15
Q

What are the common parasites seen in reptiles?

A

Coccidiosis - direct life cycles, bearded dragons and snakes. Toltrazuril daily for three days by stomach tube. repeat faecal check.
Ascarids - commonly found - Direct and indirect life cycles. Large worms can cause impactions. Fenbendazole as treatment daily for three days by stomach tube.
Oxyurids - faecal analysis positive in 75% . Can build up to massive level due to direct life cycle. Many species, particularly beardies. May have a role in mixing ingesta.
Ciliates - most are commensals such as nycotheries and balantidium. High levels may be secondary to other diseases.
Treatment in the critically ill chelonian may be required.
Cryptoosporidium - protozoal with direct life cycle in lizards and snakes. 80% of oocysts reinfect the host within the host. 20% immediately infective when passed in faeces. Cause regurgitation, anorexia and stomach swellng in snakes. Emaciation due to SI disease in leopard geckos.

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16
Q

Describe how you select antibiotics in reptiles.

A

Culture samples an be taken from any lesion, faecal samples or from swabs or washes. up to 50% of reptile bacterial infections include anaerobes. Many can be secondary invaders. Generally a culture sample will grow organisms. Most will be gram negative and have multiple resistance. Only one antibiotic is licensed for use in exotic species - enrofloxacin. This is bactericidal and is effective against aerobic bacteria only. Its efficacy against gram negative species is high including pseudomonas. Synergism with other bactericidal antibiotics can improve effective kill further. Ceftazidime is a third generation cephalosporin. Its bactericidal and has excellent activity against gram negatives including pseudomonas sp. Pharmacokinetic studies in snakes and tortoises demonstrated that 20mg/kg every 72 hours is appropriate. Metronidazole also can be used. Indigo snakes and king snakes have shown toxic signs with doses over 40mg/kg. Ticarcillin is also highly effective against anaerobes. it is an antipseudomonal penicillin. Available in combination with clavulanate.

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17
Q

What are the most common injection sites?

A

Intramuscular - pectoral muscles. Or caudal aspect of the upper t high can be used in animals that may bite or trap your fingers. For lizards the muscles over the rib cage can be used or into the limb muscles. Pain can lead to temporary discolouration at the injection site. In snakes - most commonly use the epaxial muscles.

18
Q

What is the renal portal system?

A

In snakes an lizards blood from the tail and hindlegs either flows to the kidney or enter the general circulation and flow to the liver. Blood entering the renal portal system goes to the kidneys first and passes round the renal tubules. Drugs that are excreted by this route or are nephrootoxic should be injected elsewhere.

19
Q

Why are nasal flushes and tracheal washes useful?

A

Respiratory disease is very common in chelonia. Pathogens such as mycoplasma, herpes virus, bacteria and fungi can be involved. Swabs, flushes and washes can be used to collect diagnostic samples. In addition to culture and cytology, PCR testing is now available for herpes and mycoplasma sp. PCR samples - use a sterile saline moistened swab, if sampling from the mouth then starve the tortoise. Respiratory disease is very common in snakes but less so in lizards. Pathogens such as mycoplasma, paramyxoviruses, chlamydoophila, bacteria and fungi can be involved. swabs flushes and washes can be used to collect diagnostic samples For tracheal wash use 1% bodyweight saline.

20
Q

Where can a tortoise be blood sampled? How can this be avoided.

A

jugular veins or carotid arteries or dorsal coccygeal vein or subcarapacial sinus. right side usually biger. Haematoma are possible particularly if the carotid artery is used. To avoid this aim towards the dorsal neck and apply digital pressure after sampling. Subcarapacial sinus is a sinus formed from the confluence of the external jugular veins and the intercostal vessels. A lymph heart overlies the site of venipuncture. Lymph dilution is less likely from the jugular or carotid vessels and has been reported when the clinician was unable to visualise the vessels.

21
Q

Where can snakes be blood sampled from?

A

Ventral tail vein or cardiac. If cardiac sampling you need to apply digital pressure in front of and behind the heart to stop it moving.

22
Q

Where can lizard blood be taken from?

A

Ventral tail vein, jugular or ventral abdominal vein.

23
Q

What are different about reptile blood cells compared to mammals?

A

All reptiles have nucleated red blood cells. they are much larger than mammalian erythrocytes. They are able to regenerate from pleuropotential thrombocytes within the circulation. reptiles do not have platelets. A regenerative response can include immature red cells, polychromasia and in severe cases mitoses within the circulation. this is all normal. A low level of polychromasia is expected in all films. This is particularly evident after hibernation. Reptiles can cope well with blood loss well due to their ability to utilise anaerobic metabolism. The erythroocytes can last for up to 800 days and there is a much slower turn over compared to mammals. There is season variation based on hydration status. Samples should be in heparin as ETA can occasionally lyse squamate RBCS. The main difference in the white cells is the heterophil which has actions similar to the mammalian neutrophil. Squamates have granulocytes and agranulocyts. their morphology is more important than their numbers. Numbers can be very low in severe infections. Granulocytes consist of heterophils and eosinophils. Toxic activity indicates a response to an insult.

24
Q

Which views are used for visualising what in snakes and lizards?

A

Dorsoventral vertical - for GI tract, repro disease, shell and limbs
Lateral horizontal beam views - require rotation of the xray head ad permission from the RPA. Ideal for lung fields.

25
Q

What are the standard views used for radiography in chelonians?

A

Dorso ventral vertical beam - ideal for GI tract, reproductive disease, shell and limbs.
Lateral horizontal beam views
Do a cranial caudal view and a lateral view - ideal for lung fields.

26
Q

Which nsaids should be used in reptiles?

A

Should be used as a routine. No reason not to give intravenously with fluids. only pharmacokinetic studies in reptiles using meloxicam and ketoprofe. THese are the agents of choice.

27
Q

Describe the respiratory anatomy of the tortoise

A

They have a simple glottis at the base of a fleshy tongue. they can be one of the hardest reptiles to intubate. The trachea is made of solid rings that can bifurcate into bronchi very quickly depending on species. The bronchi course dorsally to enter the lungs. These are multichambered up to eleven. Major trabeculae divide these chambers. The respiratory surface consists of ediculi - wider and flatter than alveoli.

28
Q

Describe the respiratory anatomy of a snakke

A

Snakes tend to have solid rings initially to prevent compression of the trachea when ingesting large prey items. Their glottis is highly mobile to prevent damage when taking prey. snakes usually only have the right lung functional. some species such as boas have a smaller left lung. Others have a tracheal lung that opens dorsally from the trachea.

29
Q

What is cardiovascular shunting?

A

reptiles have a small left to right shunt. This re circulates oxygenated blood round the lung fields. Breath holding reptiles have a right to left shunt and effectively cut the lungs out of the circulatioon. Some residual blood left in the cavum venosum in diastole leads to some mixing of blood. Some reptiles can respire via the skin, cloaca and pharynx and so pulmonary respiration can have a lower importance.

30
Q

How can anaesthesia be monitored in reptiles

A

Heart rate can be assessed using a doppler probe situated at the heart base. A heart rate of 30-40 BPM would be expected for a anaesthetised reptile. In small tortoises it is possible to place it over the heart through the plastron. In lizards it is best placed between the front legs. In snakes the apex beat should be observed and the doppler placed here. This is usually 22-33% of the snout to vent length. Tail pinch, toe pinch, head withdrawal responses an jaw tone can be used to guage the plane of anaesthesia.

31
Q

Describe the surgical technique of placing a feeding tube

A

Place a long pair of handled haemostats down the oesophagus. Elevate them to one side behind the mandible or as far down as possible. Incise with a scalpel over the instrument tip. Advance the haemostats and grab the tube. Pull out of the mouth and cut to length. Insert down the oesophagus and suture in place.

32
Q

What is stomatitis?

A

Very commonly seen in snakes and less common in lizards. can be due to bacterial, viral or fungal agents. May cases can be a result of repetitive trauma due to escape attempts through transparent barriers. Radiography of the jaw and maxillae are required to check for any bone involvement. Surgical debridement is ideal. In these cases using topical therapy such as an iodine based disinfectant or silversulphasalaine cream combined with antibioics to cover anearobes as well.

33
Q

Describe periodontal disease seen in lizards

A

This is a condition which is hugely under diagnosed in acrodont lizards. The teeth sit on top of an exposed bony ridge in the mouth. Trauma from bashing into glass can lead to gingival recession and exposed bone and subsequent infection. Give antibiotics, analgesics, scale and polish all surface. Debride and remove all necrotic material. Flush or remove any abscess.

34
Q

Describe upper respiratory tract disease in chelonians

A

clinical signs - ocular discharge, dyspnoea, respiratory noise, nasal discharge, caseous oral mucosa.
Common pathogens - mycoplasma agassizzi, (horsefield tortoises have a higher incidence), Oce confirmed positive assume always a positive. Confirm by PCR of a saline moistened swab of choana, eye, discharges ad nares. Treatment with enrofloxacin.
Herpes virus - Two herpes CHV1 and CHVII - clinical signs include conjunctivitis, stomatitis and rhinitis. Common in leopard tortoises and hermanns. Transmission occurs from any secretions. Diagnosis can be performed by antibody testig, PCR, histopathology or cytology demonstrating intranuclear eosinophilic inclusion bodies consistent with a herpes virus infection.

35
Q

Which animal is septicaemia a common presenting sign in? how does this present?

A

This is common in snakes. these may have immunosuppressive viruses or poor husbandry. Many present as anorexic and have flushed reddening of their ventral scales. Blood culture can be performed and this should be assessed alongside haematology. May septic snakes can seed infection into other sites around the body. this can lead to spinal osteoarthritis. Proliferative bone production occurs and this can lead to a reduced flexibility of snake and obvious bony swellings over the site. The long term prognosis for these cases is poor.

36
Q

What are the presenting sign of paramyxovirus? what animal does this affect

A

Ophidian PMV can cause three possible presentations in snakes. Acute infections present as sudden death. minimal signs noted by owner. respiratory signs or neurological sigs are possible. The incubation period can be up to 10 weeks. Some snakes can become chronically infected leading to immune suppression. Respiratory signs, regurgitation and other GI signs are possible. Some animals can remain healthy for up to 10 months after exposure. Chronically infected animals have higher titres, acutely presenting animals have lower titres. Post mortem examination shows pneumonia which can be markedly haemorrhagic. Histopathology shows typical proliferation of type II pneumocytes within the lung an occasionally eosinophilic intracytoplasmic inclusion bodies can be seen. No treatment beyond supportive care.

37
Q

What is inclusion body disease?

A

Inclusion body disease is a common condition affecting boas and pythons. It has recently been identified in colubrid snakes and vipers as well. It produces eosinophilic intracytoplasmic inclusion bodies in the snakes and it is believed to be a retrovirus. Boas are more resistant than pythons. Clinical signs vary from neurological disease, regurgitation or weight loss. neurological disease is more common in pythons. The diagnosis depends on the demonstration of the typical inclusion bodies.. The kidneys, liver CNS and pancreas are good sites to find them. No treatment and affected snakes should be isoltaed. Quarantine should be performed for a minimum of six months. Transmission is unknown but there have ben links with the snake mite and mite control should be performed.

38
Q

Describe how snakes become infected with the snake mite, what are the clinical signs of infected animals, how can this be treated?

A

The initial source of infection is usually from a newly acquired animal. These are motile parasites that produce eggs when are laid in the environment. These hatch to produce nymphs which then feed on the host animal prior to developing into adults. The whole life cycle takes 13-19 which allows numbers to increase dramatically. The mites like to hide in skin folds and a close inspection around the eyes, mouth, gular folds and cloaca are good places to find them. Reptiles with mites are pruritic and spend a lot of time soaking in water bowls and can do self trauma. Dysecdysis is a common secondary complication in snakes. Ivermectin made into a spray formulation works well. An alternative is fipronil as a wipe.

39
Q

What is nutritional secondary hyperparathyroidism? How do affected animals present with this and how can it be treated?

A

Metabolic bone disease - problems caused by dietary deficiency in calcium, imbalances in calcium to phosphorus ratio or hypovitaminosis D. A lack of vitaminD can be due to either dietary deficiency or failure to provide adequate UVb radiation. A critical review of heating, lighting and diet is therefore mandatory. Clinical signs common seen include a soft compressible jaw or shell and a lack of truncal filling. Thickening of the plastrocarapacial bridge and ventral deviation of the carapace often occurs in chelonians. In male hemipenile prolapse is a common finding. Fractures of the limbs are common and there can be marked deviations of the limbs leading to difficulty ambulating. Tetany is possible if the blood ionised calcium drops in lizards or flaccid paralysis In chelonians and is most common in juveniles. Treatment includes placement of an oesophagostomy tube, uv B light, phosphate binders such as aluminium hydroxide and oral or systemic calcium therapy. calcium gluconate by injection every 6 hours is recommended if ionised calcium is reduced.

40
Q

What is pyramidal growth caused by in tortoises?

A

Common in captive bred tortoises. OVer feeding high protein sources and a low humidity environment are predisposing factors. Existing pyramiding will never go away but with correction of husbandry can instigate more normal growth. a higher humidity environment can be created by providing a box with a small entrance hole. Foam stuck into the roof can be sprayed repeatedly with water to keep the relative humidity high.

41
Q

Which reproductive diseases are common in lizards and chelonians?

A

Very common in female lizards and chelonans. Many reptiles need to be exposed to a male to induce ovulation. Naturally female lizards and snakes go off food when gravid. This is due to the fill of the coelomic cavity with developing follicles.This places a huge demand on their reserves and metabolic problems with hypocalcaemia and condition loss can be seen leading to collapse. Infections and Abscessation of the follicles is possible and they can rupture leading to an egg coelomitis. Stasis of the follicles is also possible. Egg stasis is also possible due to a lack of appropriate environmental stimuli such as a suitable nesting, temperature, heat, privacy etc. May females may lack the appropriate physiological and behavioural cues to lay eggs. Females that have eggs to lay are quite particular about where they lay eggs - a familiar environment, correct temperature and humidity is required. Nutrition is impoortant, producing eggs requires a high levels of protein and calcium and marginal husbandry can have a greater effect on reproductively active females. Most females will lay eggs without exposure to a male. If there is no obvious reason for the stasis then premedication with atenolol and calcium gluconate followed by oxytocin can lead to oviposition. If there are no shelled ova present then surgery is required. If thereare no shelled ova present then surgery is required.

42
Q

How can skin trauma occur in reptiles?

A

Trauma can be from other household pets, conspecifics, prey items or due to burns from inappropriate heat sources such as mats or hot rocks. Secondary infections with bacterial or fungal agents are common. These can occur as primary conditions where husbandry is Poor and the animal is in squalid conditions. As reptiles shed their skin regularly the healing capacity is huge and substantial wounds can heal providing.Wounds require aggressive debridement and flushing. Cultures can be taken and biopsy may be indicated. Underlying damage to the body wall and bony elements is possible. Punctures into the coelomic cavity is also highly likely. A thorough examination under anaesthesia is warranted and radiography may be required for a complete evaluation. Standard dressings and products used for dogs and cats are appropriate based on the wound type. Silver based products have a high level of activity against gram negatives. Infection with the chyrososporium annamorph of Nannisisopsis viresi (yellow fungal disease), is becoming a common primary fungal pathogen of squamates.

43
Q

What is the cause of dysecdesis? How can this be treated?

A

Low relative humidity can lead to ysecdysis, respiratory disease, skin disease. A second layer of skin is produced from the basal layer and lymph enters the cleavage zone to separate the old skin from the new. At this stage snakes and lizards may go a dull clour and because the snakes have skin over their eyes then this lymph imparts a blue colour to the eyes. This is known as being in the blue and lasts for three days. After this time the lymph clears and three days later the snake sheds its skin. Sakes shed in one go and checking to ensure the specacles have come away is not important. Retained shed can lead to constriction of the digits and tails. Snakes and lizards can suffer from dyspnoea if it obstructs the nares. Dysecdyses occurs when the skin is not shed and can be due to lack of humidity or due to skin infections, parasite or trauma or general debility. Bathing and topical ocular lubricants can be used to soften retained spectacles. Anaesthesia and gentle manipulation of retained spectacles or skin forceps may be required to prevent loss of digits or vision.