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Spring Pharm 2 > Reproductive Toxicology > Flashcards

Reproductive Toxicology Flashcards

1
Q

AMES test

A

Identifies mutagenic materials using sample bacteria– doesn’t always transfer to other tests, subjects

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2
Q

0.05 rads

A

Background

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3
Q

0.5 rads

A

no effect

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4
Q

5 rads

A

Counseling threshold

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5
Q

50 rads

A

Microcephaly, mental retardation

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6
Q

5000 rads

A

Abortion

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7
Q

Valproic acid

A

Seizure tx/migraine
Category D
Spina bifida 20x
10% risk overall - autism, cognitive impairment

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8
Q

Isotretinoin

A

Category X

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9
Q

OTC

A

Category X

No inc in birth defects, just contraindicated in pregnancy

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10
Q

Thalidomide

A

Was prescribed for morning sickness in 1950s
Selectively toxic to embryo - Category X
Abnormal limbs
Embryo harmed before maternal effects

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11
Q

ACE-I

A

Category D
During 2nd trimester, can cause renal insufficiency via poisoning fetal RAAS system
CV defects

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12
Q

Diethylstilbestrol (DES)

A

Given to prevent miscarriage, diabetes

Causes clear cell carcinoma - vagina cancer

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Spring Pharm 2 (5 decks)

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