REproductive System Flashcards

1
Q

Progesterone

A

Hormone of Pregnancy

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2
Q

Drugs for Female reproduction

A

Sex hormones
Estrogen receptor modulators
Fertility drugs
Uterine motility drugs

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3
Q

Estrogen

A

Estradiol (Estrace, Climara)
Conjugated estrogens (Premarin)
Esterified estrogen (Menest)
Estropipate (Ogen)

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4
Q

Indications for Estrogen

A

Hormone replacement therapy

Key for the development if the female reproductive system and secondary sex characteristics

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5
Q

Contraindications for estrogen

A
Estrogen dependent cancer
Breast cancer
Idiopathic vaginal bleeding
Pregnancy and lactation
Smoker
HTN
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6
Q

Sex Hormones

Progestin

A
Progesterone
Drospirenone
Etonogestrel
Lovenogestrel
Medroxyprogesternone
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7
Q

Indications for Progestin

A

Used as contraceptives
Maintain pregnancy and development of secondary sex characteristics
Used to treat primary and secondary amenorrhea and functional uterine bleeding

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8
Q

Contraindications for progestin

A
High risk for embolic events
Pelvic inflammatory disease
Endometriosis
Pelvic surgery
Renal and hepatic disorders 
Migraine headaches
Cardiac dysfunction
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9
Q

Prototype Norethindrome Acetate

A

DVT!!

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10
Q

Adverse Effects of Sex Hormones

A
Higher chance for embolic events
Change in menstrual flow
Peripheral edema
Increase risk for Breast Ca
Breakthrough bleeding
Delay conception for 3 mos after DC of progesterone
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11
Q

Estrogen Receptor Modulators

A

Stimulate specific estrogen receptors
Increase bone mass without stimulating the endometrium
Treatment of osteoporosis in postmenopausal women

Examples include:
Raloxifene (Evista)
Toremifene (Farestone

NEXT !!!
Are used to stimulate specific estrogen receptors to achieve therapeutic effects of increase bone mass without stimulating the endometrium and causing other less desirable effects. These stimulates the estrogen receptor in a body so that it could function to produce estrogen which is needed by the body for normal functioning

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12
Q

Contraindications

A

Venous thrombosis
Pregnancy
Lactation
Smoking

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13
Q

Adverse Effects

A
Venous thromboembolism (know this!)
Hot flashes
Skin rash
Nausea 
Skin rash
Vomiting
Vaginal bleeding
Depression
Lightheadedness
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14
Q

Estrogen Receptor Modulators

Drug-to-drug interactions

A
Warfarin
Cholestyramine
Diazepam (Valium)
Ibuprofen (Motrin)
Indomethacin (Indocin)
Naproxen (Naprosyn)

Cholesterol, NSAIDS, anti-anxiety, blood thinner

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15
Q

Prototype Estrogen Receptor Modulators

A

Raloxifene

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16
Q

Fertility Drugs

A

Cetrorelix
Chorionic gonadropin
Clomiphene
Menotropins

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17
Q

Actions

A

Work to stimulate ovulation
Stimulate the hypothalamus to increase FSH and LH levels
Follicle stimulating hormone and leutinizing hormone
By stimulating the foliicle stimulating hormone and leutinizing hormone
To stimulate ovulation

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18
Q

Contraindications

A
Thromboembolic disease (DVT)
Presence of primary ovarian failure
Thyroid and adrenal dysfunction
Ovarian cyst
Pregnancy
Idiopathic uterine bleeding
Known allergies
Breast-feeding
Respiratory diseases
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19
Q

Adverse Effects

A
Multiple pregnancies
Abdominal discomfort
Distention and bloating
Nausea and vomiting
Breast tenderness
Vasomotor flushing
Visual changes
Ovarian enlargement
20
Q

Uterine Motility Drugs

A

It stimulates uterine contraction
Labor (oxytocics)
Abortion (abortifacients)

Next is uterine motility drugs
It stimulates uterine contractions to assist labor OR to abort
Separated in two. Labor or abort

21
Q

Oxytocics

A

Stimulate contraction of the uterus
Help placenta delivery
Aid in post partum hemorrhaging
Methylgronovine (Methergine)
Oxytocin (Pitocin)
First is oxytocics, it mainly stimulates the contraction activity of the uterus
It can also help facilitate placenta delivery
And address post partum hemmorhaging
Ask me about placenta delivery or non delivery of the placenta in clinicals

22
Q

Actions

A

Directly affects neuroreceptors sites to stimulate contractions of the uterus
Effective in the Gravid uterus
Promotes milk ejection in lactating women
Prevents and treat uterine atony post delivery
It is not just for the contraction of uterus, but also for the milk ejection in lactating women.
Uterine atony,or failure of the uterus to contract following delivery, is the most common cause of postpartum hemorrhage.

23
Q

Contraindications

A
Allergies
Cephalopelvic disproportion
Complete uterine atony
Early pregnancy
CAD
HTN
Previous cesarian section
Hepatic and renal impairment
24
Q

Adverse Effects

Severe H2O intoxication

A
Uterine rupture
Painful contractions
Cardiac arrythmias
HTN
Fetal bradycardia
N/V
Pelvic hematoma
Uterine hypertonicity
Severe H2O intoxication
Uterine hypertonicity- especialiy if we have an OD of oxytocic agent
So it would stimulate or over stimulate the uterus
Has antidiuretic effects
Watch for neuro changes since it messes with electrolytes
25
Oxytocin (Pitocin)
Monitor contractions Less than 60 secs Every 2-3 mins Stop infusion if it is longer Monitor maternal and fetal BP and pulse Magnesium can be used to relax the uterus If a patient is having contractions for 90 secs, that is too long. Oxytocin should be DC’ed Mag to counter the oxytocin by relaxing the uterus
26
Prototype Oxytocics
Oxytocin
27
Abortifacients Used to evacuate uterine content Used to induce abortions
``` Carboprost Dinoprostone Mifepristone On the flipside, aborificients are Used to evacuate uterine content via intense uterine contractions Abortion drug We are going to focus on these 3 drugs ```
28
Action of Abortifacients
Stimulate uterine activity | Dislodging any implanted throphoblast and preventing fertilization of egg
29
Contraindications
``` Allergies Active PID Acute CV, hepatic, renal, or pulmonary diseases Lactation Scarred uterus Acute vaginitis ```
30
Adverse Effects
``` Uterine rupture Uterine or vaginal pain Headache Paresthesia Hypotension Vomiting Diarrhea Chills Diaphoresis Backache fever ```
31
Tocolytics Drugs to slow uterine activity Terbutaline
Before we end the drugs affecting the female reproductive system. We gotta talk about tocolytics It is a drug that slows uterine activity. it is for pre-term labor Terbutaline will delay arrival time of the baby Delays, but not prevent labor
32
Terbutaline
Other uses COPD Asthma ``` Side Effects Tachycardia Angina Restlessness Tremors ```
33
Terbutaline | Contraindication
Gestation >34 weeks Cervical dilation > 6 cm Because the delivery of the baby is inevitable from that point
34
Other tocolytics Nifedipine (Ca channel blocker) Magnesium Given IV at this stage
Watch for magnesium toxicity Calcium gluconate antidote for Mag toxicity Endomethacine (NSAIDS) Nifedipine to suppress contraction. Watch out for orthostatic hypotension since it is mainly used to lower BP. Watch for magnesium toxicity Decreased DTR, U/O <30 ml/hr, respiratory depression Too much mag lowers these things Endomethacine – blocks prostaglandin syhnthesis which suppresses labor
35
Drugs affecting the male reproductive system
Androgens Anabolic steroids Drugs for penile erectile dysfunction
36
Androgens Male sex hormones Testosterone Androgens
``` Examples Testosterone Danazol Fluoxymesterone Methyltestosterone ``` ``` Anadrol-50 Androderm Androgel Android Androxy Axiron Danocrine DHEA First-Testosterone Testosterone – produced in the testes. Responsible for male characteristics before puberty Androgens – produced in the adrenal glands, sustains male characteristics after puberty Testosterone in the drug name ```
37
Actions
Responsible for the grown the development of male sex organs Maintenance of secondary male characteristics Increase protein anabolism Decrease protein catabolism
38
Contraindications
``` Allergies Pregnancy and lactation Prostate or breast Ca Liver dysfunction High potential for abuse ``` Cardiovascular disease
39
Adverse effects
``` Sleep disorders Fatigue Androgenic effects Acne Deepening of voice Oily skin Hepatocellular carcinoma Hypercholesterolemia Polycythemia Premature epiphyseal closure ``` Cardiovascular disease In women, they become manly with deep voice and hair growth
40
Anabolic Steroids
Analogous of testosterone Developed to produce tissue building effects Drugs Oxandrolone Oxymetholone The second drug that affetcts the male reproductive system is anabolic steroids Developed to produce tissue building effect with led androgenic effect
41
Actions
Promote body tissue building process Reverse catabolic process Increase Hgb and RBC mass ``` Indication Anemia Cancer (give to cancer pt to increase muscle mass) Angioedema Weight gain Tissue repair ```
42
Contraindications
``` Allergies Pregnancy Lactation Prostate or breast Ca Liver dysfunction CVD Same as androgens ```
43
Adverse effects
Virilization – development of male characteristics | ?
44
Drugs for penile erectile dysfunction | These are vasodilators
Drugs Slidenafil (Viagra) Tadalafil (Cialis) Verdenafil (Levitra) What is penile erectile dysfunction? A condition in which the corpus cavernosum does not fill with blood to allow for penile erection. Results from aging process and in vascular and neurological condition.
45
Actions
Acts locally to relax smooth muscle and allow filling of corpus cavernosum It would allow for sustained erection
46
Contraindication Which one is the double whammy vasodilator taken with viagra? Nitrates Caution: this combo will drop blood pressure
``` Priapism Penile implants Bleeding disorders CAD Severe HTN Severe hepatic and renal disorder Nitrates ``` Prolonged unwanted erection. Really bad, it hurts, may need drainage Use in caution in CAD patients as it increases the risk for MI Vasodilators X2, double whammy in the ER
47
Adverse Effects
Priapism - unwanted erection that will not go away, last for hours, too much blood flow, and it is painful! Increased risk for MI