REproductive System Flashcards
Progesterone
Hormone of Pregnancy
Drugs for Female reproduction
Sex hormones
Estrogen receptor modulators
Fertility drugs
Uterine motility drugs
Estrogen
Estradiol (Estrace, Climara)
Conjugated estrogens (Premarin)
Esterified estrogen (Menest)
Estropipate (Ogen)
Indications for Estrogen
Hormone replacement therapy
Key for the development if the female reproductive system and secondary sex characteristics
Contraindications for estrogen
Estrogen dependent cancer Breast cancer Idiopathic vaginal bleeding Pregnancy and lactation Smoker HTN
Sex Hormones
Progestin
Progesterone Drospirenone Etonogestrel Lovenogestrel Medroxyprogesternone
Indications for Progestin
Used as contraceptives
Maintain pregnancy and development of secondary sex characteristics
Used to treat primary and secondary amenorrhea and functional uterine bleeding
Contraindications for progestin
High risk for embolic events Pelvic inflammatory disease Endometriosis Pelvic surgery Renal and hepatic disorders Migraine headaches Cardiac dysfunction
Prototype Norethindrome Acetate
DVT!!
Adverse Effects of Sex Hormones
Higher chance for embolic events Change in menstrual flow Peripheral edema Increase risk for Breast Ca Breakthrough bleeding Delay conception for 3 mos after DC of progesterone
Estrogen Receptor Modulators
Stimulate specific estrogen receptors
Increase bone mass without stimulating the endometrium
Treatment of osteoporosis in postmenopausal women
Examples include:
Raloxifene (Evista)
Toremifene (Farestone
NEXT !!!
Are used to stimulate specific estrogen receptors to achieve therapeutic effects of increase bone mass without stimulating the endometrium and causing other less desirable effects. These stimulates the estrogen receptor in a body so that it could function to produce estrogen which is needed by the body for normal functioning
Contraindications
Venous thrombosis
Pregnancy
Lactation
Smoking
Adverse Effects
Venous thromboembolism (know this!) Hot flashes Skin rash Nausea Skin rash Vomiting Vaginal bleeding Depression Lightheadedness
Estrogen Receptor Modulators
Drug-to-drug interactions
Warfarin Cholestyramine Diazepam (Valium) Ibuprofen (Motrin) Indomethacin (Indocin) Naproxen (Naprosyn)
Cholesterol, NSAIDS, anti-anxiety, blood thinner
Prototype Estrogen Receptor Modulators
Raloxifene
Fertility Drugs
Cetrorelix
Chorionic gonadropin
Clomiphene
Menotropins
Actions
Work to stimulate ovulation
Stimulate the hypothalamus to increase FSH and LH levels
Follicle stimulating hormone and leutinizing hormone
By stimulating the foliicle stimulating hormone and leutinizing hormone
To stimulate ovulation
Contraindications
Thromboembolic disease (DVT) Presence of primary ovarian failure Thyroid and adrenal dysfunction Ovarian cyst Pregnancy Idiopathic uterine bleeding Known allergies Breast-feeding Respiratory diseases
Adverse Effects
Multiple pregnancies Abdominal discomfort Distention and bloating Nausea and vomiting Breast tenderness Vasomotor flushing Visual changes Ovarian enlargement
Uterine Motility Drugs
It stimulates uterine contraction
Labor (oxytocics)
Abortion (abortifacients)
Next is uterine motility drugs
It stimulates uterine contractions to assist labor OR to abort
Separated in two. Labor or abort
Oxytocics
Stimulate contraction of the uterus
Help placenta delivery
Aid in post partum hemorrhaging
Methylgronovine (Methergine)
Oxytocin (Pitocin)
First is oxytocics, it mainly stimulates the contraction activity of the uterus
It can also help facilitate placenta delivery
And address post partum hemmorhaging
Ask me about placenta delivery or non delivery of the placenta in clinicals
Actions
Directly affects neuroreceptors sites to stimulate contractions of the uterus
Effective in the Gravid uterus
Promotes milk ejection in lactating women
Prevents and treat uterine atony post delivery
It is not just for the contraction of uterus, but also for the milk ejection in lactating women.
Uterine atony,or failure of the uterus to contract following delivery, is the most common cause of postpartum hemorrhage.
Contraindications
Allergies Cephalopelvic disproportion Complete uterine atony Early pregnancy CAD HTN Previous cesarian section Hepatic and renal impairment
Adverse Effects
Severe H2O intoxication
Uterine rupture Painful contractions Cardiac arrythmias HTN Fetal bradycardia N/V Pelvic hematoma Uterine hypertonicity Severe H2O intoxication Uterine hypertonicity- especialiy if we have an OD of oxytocic agent So it would stimulate or over stimulate the uterus Has antidiuretic effects Watch for neuro changes since it messes with electrolytes