Reproductive Surgery Flashcards
List the 3 surgical diseases of the ovary.
- ovarian cysts
- ovarian neoplasia
- ovarian remnant syndrome
On routine OHE of an otherwise completely healthy cocker spaniel, you find an ovarian cyst. How should you continue on with this patient?
OHE is curative for nonfunctional ovarian cysts so continue on with the OHE. Submit the ovaries, including the cysts, for histopathology to confirm diagnosis of nonfunctional ovarian cysts.
Functional ovarian cysts are hormone secreting cysts and can be follicular or luteal. A follicular cysts secretes ____________ and a luteal cyst secretes ___________
Follicular cyst: estrogen
Luteal cyst: progesterone
Functional ovarian cysts are hormone secreting cysts. What signalment and clinical signs are typical of a functional ovarian cyst in dogs and cats?
Dogs - <3 years old
Cats - <5 years old
CS: prolonged estrus, vaginal bleeding (dogs), attractiveness to males, and standing heat
Diagnosis of Functional Ovarian Cysts can be made by…
Which of the methods is best?
vaginal cytology (dogs) hormone levels (estrogen: >20pg/ml; progesterone: >2ng/ml) abdominal ultrasound (cysts are 10-50mm in size) - best diagnostic method
Treating a functional ovarian cyst in a breeding animal differs from treatment in a non-breeding animal by…
Breeding animal: spontaneous resolvement, GnRH, HCG, Cyst removal, unilateral ovariectomy
Non-breeding animal: OHE is curative
T/F: Ovarian neoplasia is a common form of neoplasm in small animal patients.
False.
Ovarian neoplasia is approximately 1% of neoplasia in small animal patients >10 years of age.
What is the percent metastasis in ovarian neoplasia in small animal patients?
Ovarian neoplasia typically metastasizes in 20-30% of patients.
50% of ovarian neoplasia is of epithelial origin. What is the malignant and benign form of this neoplasm?
Malignant: Adenocarcinoma
Benign: Adenoma
40% of ovarian neoplasia is of stroll origin. What is the form of this neoplasm and how does it manifest??
Granulose Cell Tumor
Persistent pro-estrus because it is a functional hormone producing tumor that can lead to pyometra.
A small percentage of ovarian neoplasia is of germ cell origin. What is the typical signalment for these neoplasms and what are the 2 types of neoplasms within this tissue of origin?
Patients are <5 years old at presentation.
- Dysgerminoma
- Teratoma
What diagnostics would you implement in order to diagnose ovarian neoplasia?
Radiographs - see a space occupying lesion
Ultrasound - MOST SENSITIVE!
AVOID A FNA!
After diagnosing an Ovarian Adenocarcinoma in a 9 year old female, intact West Highland Terrier, you take full body radiographs and determine there is no detectable metastasis. What treatment of choice do you offer your client?
Ovariectomy
Good prognosis if there is no metastatic disease.
What is the most common surgical condition of the ovary?
Ovarian Remnant Syndrome
What is the definition of Ovarian Remnant Syndrome?
recurrence of estrus following OHE/OVE most likely due to failure of removal of all ovarian tissue - poor technique!
Ovarian remnant syndrome is more common in ______.
cats
Cats require ___________ in order to evaluate their progesterone levels.
lutinization (HCG)
In a cat with suspected ovarian remnant syndrome, diagnostic estrogen levels should read _________ and diagnostic progesterone levels should read _________.
estrogen levels > 15pgm/ml
progesterone levels > 2ng/ml
Clinical signs typical of ovarian remnant syndrome are….
signs of estrus
On vaginal cytology of a DOG with suspected ovarian remnant syndrome, you see….
what mimics a normal heat cycle
Where is ovarian remnant usually located?
At the Caudal Pole of the Kidney
What is the treatment of choice for ovarian remnant syndrome?
surgical removal
When is surgery usually done for patients with ovarian remnant syndrome?
surgery is usually done during estrus - it is often a referral procedure
List the 7 surgical diseases of the uterus.
- cystic endometrial hyperplasia
- pyometra
- metritis
- uterine torsion
- uterine rapture
- dystocia
- uterine neoplasia
Cystic endometrial hyperplasia is associated with….and can lead to ________.
excess and prolonged PROGESTERONE!
Can lead to PYOMETRA!
Clinical signs of cystic endometrial hyperplasia include….
poor fertility
failure to conceive
vaginal discharge
PU/PD
The best/most sensitive diagnostic method for cystic endometrial hyperplasia is ___________ and the recommended treatment is ___________.
ultrasound; OHE
Diestrus results in progesterone secretion which results in endometrial hyperplasia. IF the bitch/queen is pregnant, the endometrial hyperplasia regresses post-parturition. If the bitch/queen is NOT pregnant, the resultant non-gravid uterus causes the endometrium to _____________, causing cystic hyperplasia which is susceptible to __________ and can ultimately lead to ______________.
…the resultant non-gravid uterus causes the endometrium to REMAIN HYPERPLASTIC, causing cystic hyperplasia which is susceptible to BACTERIAL CONTAMINATION and can ultimately lead to PYOMETRA.
Bacteria + Cystic Uterine Disease = ___________
PYOMETRA!
The definition of Pyometra is….
infection of the uterus
When does pyometra typically occur?
Pyometra occurs 4-8 weeks after the heat cycle.
Pyometra is more/less common in cats than dogs.
Pyometra is less common in cats than dogs.
Pyometra develops during what part of the heat cycle?
Diestrus
How does estrogen contribute to the development of pyometra?
estrogen increases/sensitizes progesterone receptors
The pathophysiology behind pyometra development begins with….
prolonged/elevated progesterone levels
The most common bacteria in a pyometra is…
Others include…
E. Coli
Pastuerella, Proteus sp., Pseudomonas
The bacterial spread in pyometra is via what 2 methods and which is most common?
Ascending (most common)
Hematogenous
Why is pyometra less common in cats?
Cats are induced ovulates and therefore have a less chance of experiencing/accumulating excess progesterone.
Typical clinical signs of a pet with pyometra include…how many of these clinical signs do most pyometra cases have?
Most pyomtera cases present with 3 or more of the following clinical signs: Lethargy Vomiting PU/PD Vaginal discharge*
*Vaginal discharge may be the only clinical sign if the cervix is open.
What clinical sign may be the ONLY sign of pyometra with an open cervix?
Vaginal Discharge
What is often the most noticeable clinical sign of pyometra and why does it occur?
PU/PD is often the most noticeable clinical sign.
Pathophysiology: Bacterial toxins inhibit the concentrating ability (ADH) and causes glomerular damage.
What physical exam findings are expected in a patient with pyometra?
painful, distended abdomen
tachycardia
tachypnea
FEVER (a subnormal temperature is BAD NEWS!)
What TPR and CBC finding(s) are expected in a patient with SIRS and how often does SIRS occur in pyometra patients?
57% of patients with pyometra develop SIRS
T - >103.5 or <100
P - HR > 160bpm
R - >20 breaths/min.
WBC - >12,000; <4,000; or >10% bands
A chemistry panel in a patient with pyometra typically shows….
Hypoglycemia Azotemia, Proteinuria Anemia Leukocytosis Increased AST and ALP
Why does a patient with pyometra develop anemia?
There are RBCs lost in the vaginal discharge as well as a decrease in erythropoiesis.
Glomerular disease also decreases EPO production meaning you may need to RX: Whole Blood to your patient(s) if they have a low PCV.
On radiographs, a pyometra presents as….
large, fluid filled uterus
Ultrasound is a better diagnostic tool.
When can you rule out pregnancy in a patient with suspected pyometra?
You CANNOT rule out pregnancy until >42 days post ovulation…only then could you see the fetal skeletons.
On ultrasound, a pyometra presents as….
fluid filled uterus
thickened uterine wall
cystic endometrium
you can visualize the bladder (for a UTI) but DO NOT obtain a sample!
What type of antibiotics do you choose when treating a patient with pyometra?
Gram Negatives
Ampicillin or Enrofloxacin
The treatment of choice for patients with pyometra is…..
OHE
List the complications associated with medically treating a patient with pyometra.
abdominal pain emesis tachycardia dyspnea systemic deterioration
It is very important to inform owners that choose to treat their pyometra pets medically….
the bitch/queen must whelp at their next cycle!
The definition of metritis is…
inflammation and/or infection of the uterus
When is an animal susceptible to developing metritis?
Metritis occurs postpartum - between 12 hours to 1 week postpartum.
The typical clinical signs associated with metritis include…
FOUL SMELLING REDDISH BROWN DISCHARGE FEVER Anorexia Lethargy DECREASED MILK PRODUCTION
When an owner complains that “the puppies are crying all of the time”, you should suspect what disease?
metritis of the mom
Causes of metritis include (3)…
Dystocia
Devitalized uterus
Fetal/Placental retention
Treatment of choice for animals with metritis are…
antibiotics for breeding animals
OHE**
T/F - An OHE will prevent a new mother from producing milk to feed her puppies.
FALSE! They still produce milk.
Uterine torsion is defined as….
uterine torsion is the twisting of the uterus along its long axis
Uterine torsion is associated with what 3 conditions?
Uterine torsion is associated with
- dystocia
- pyometra
- cystic endometrial hyperplasia
The typical clinical signs associated with uterine torsion include…
acute abdomen
abdominal distension
shock
T/F - The diagnostic method of choice for uterine torsion is ultrasound.
FALSE - Ultrasound is non-diagnostic for uterine torsion.
Final diagnosis is usually made on exploratory.
Treatment of a uterine torsion includes…
supportive care - fluids and analgesics
OHE - do NOT derotate the tossed uterus; remove any puppies by c-section
The definition of uterine prolapse is…
uterine prolapse is the protrusion of uterine tissue outside of the vulva
Uterine prolapse is rare in both dogs and cats but is LESS RARE in ______.
Uterine prolapse is rare in dogs and cats but is LESS RARE in CATS.
When and why does uterine prolapse typically occur?
Uterine prolapse is a complication of parturition/dystocia and occurs <48 hours postpartum.
Clinical signs of uterine prolapse include…
vaginal discharge
straining
licking of the affected area
visible protruding mass
What are the treatment options for correcting a prolapsed uterus?
- manual reduction - only if there is healthy, undamaged tissue
- OHE
- Ovary removal and uterine harm aputation via ventral celiotomy - when reduction cannot be accomplished
90% of uterine neoplasia in the dog is….
Leiomyoma
the other 10% is Leiomyosarcoma
The uterine neoplasia found more in cats is….
Adenocarcinoma and likely metastatic!
The treatment of choice for uterine neoplasia is…
OHE
What is the prognosis of uterine neoplasia with OHE in the dog and cat?
Dog - good (benign tumors) to fair (malignant tumors)
Cat - guarded (higher metastatic potential)
The definition of dystocia is…
Dystocia is the inability to expel a fetus through the birth canal.
75% of dystocia cases are due to maternal causes. Maternal causes include…
Primary uterine inertia
Secondary uterine inertia
Birth canal obstruction due to a small pelvic canal or a malunion fracture.
25% of dystocia cases are due to fetal causes. Fetal causes include..
malposition
malformation
oversized neonates
secondary uterine inertia
Define primary uterine inertia.
Primary uterine inertia is with parturition fails to proceed - aka no neonates are born - and the birth canal, fetal size, and fetal presentation are all normal.
An oversized litter causes uterine _____________ to the point where it cannot contract, leading to PRIMARY UTERINE INERTIA.
An oversized litter causes uterine STRETCHING to the point where it cannot contract, leading to PRIMARY UTERINE INERTIA.
An undersized litter causes a decrease in uterine ______________, ultimately leading to PRIMARY UTERINE INERTIA.
An undersized litter causes a decrease in uterine STIMULATION, ultimately leading to PRIMARY UTERINE INERTIA.
The gestation period of dogs/cats is…..
63-68 days
Define secondary uterine inertia…
Secondary uterine inertia is a normal delivery of only PART of a litter due to the development of uterine fatigue.
Causes of secondary uterine inertia include…
- fetal obstruction
- pelvic obstruction
- fetal malposition
- fetal size
Clinical signs of secondary uterine inertia include…
prolonged interval between neonates (>4 hours)
weak or absent uterine contractions
One of the most emergent clinical signs of dystocia - when you need to tell the owner to come in immediately - is…..
One of the most emergent clinical signs of dystocia is LOCHIA WITHOUT DELIVERY.
On physical exam, signs of dystocia include…
loch without delivery
obstructed canal on palpation
abnormal fetal presentation
lack of uterine contractions in response to Ferguson’s reflex
How do you diagnose dystocia?
Radiographs
Ultrasound
T/F - Primary uterine inertia can be treated medically.
TRUE!
Secondary uterine inertia can NEVER be treated medically but, primary uterine inertia can be treated medically.
What is the treatment plan for primary uterine inertia?
Admin. oxytocin and repeat in 30 minutes if necessary (make sure the cervix has dilated before administration).
Manually manipulate the fetus(es) in the vaginal vault if they are causing obstruction.
If no result, perform a C-section.
What are the indications for a C-section?
- secondary uterine inertia
- primary uterine inertia refractory to treatment
- systemic signs in the bitch
- fetal distress diagnosed by US
- high risk patients
Where is your incision located for a C-section?
Incise midway between the xiphoid and umbilicus all the way to the cranial pubis.
Where do you clamp the umbilical cord?
Clamp the umbilical cord 2-6 cm from the abdominal wall.
When closing the uterus after a C-section of a breeding animal, what type of suture should you use and what suture pattern(s) are acceptable?
3/0 monofilament, absorbable
single layer or double layer with inversion
*If performing an OHE, there is no need for uterine closure.
What two drugs do you not want to use during neonatal resuscitation?
atropine or doxapram
What artery/arteries do the vagina and vestibule get their blood supply from?
vaginal artery from the internal pudendal artery
What are the surgical conditions of the vagina and vestibule?
Congenital Conditions:
vestibulovaginal stenosis
rectovaginal fistula
vaginal hyperplasia
vaginal prolapse
neoplasia
perivulvar dermatitis
What are the surgical procedures of the vagina and vestibule?
episiotomy
episioplasty
vaginectomy
What is an episiotomy?
Episiotomy - an approach to the caudal vagina in order to resect stenotic, hyperplastic or neoplastic lesions.
What is an episioplasty?
Episioplasty - the treatment for perivulvar dermatitis
What is a vaginectomy?
Vaginectomy - the treatment for vaginal hypoplasia, intrapelvic annular stenosis (referral procedure)
Where is your incision located for an episiotomy?
Incise through the perineal body to access the caudal vagina.
How many layers is the closure for an episiotomy?
3 layer closure:
mucosa, muscle and skin
What is a rectovaginal fistula?
Communication between the rectum and vagina.
The only congenital abnormality of the vagina or vestibule that may be simply enough to surgically correct without referral is….
septal stenosis - a derivative of vestibulovaginal stenosis
All other congenital abnormalities of the vagina or vestibule should be referred for correction.
Septal stenosis is characterized by…
a band of tissue oriented dorsoventrally.
AKA - a double vagina
What is the treatment of choice for correcting septal stenosis?
Perform an episiotomy with mucosal resection at the attachments and suture the mucosa OR laser ablation.
In vaginal edema/hyperplasia, what happens to the vaginal tissue?
The vaginal tissue becomes severely edematous and protrudes from the vulva. There may be discharge or hemorrhage from the vulva and the animal may experience breeding difficulties.
What type of condition is vaginal edema/hyperplasia and what type of animals is it commonly seen in?
It is an uncommon, familial condition in large breed dogs <2 years of age in proestrus or estrus.
What are some of the non-specific indications of vulvar disease?
licking
dysuria
perineal enlargement
Medical treatment of vaginal hyperplasia/prolapse includes administration of what drugs and what do these drugs do?
Vaginal hyperplasia/prolapse resolves ar the end of estrus.
Gonadotropin releasing hormone or human chorionic gonadotropin will induce ovulation and shorten estrus.
What surgical procedure prevents recurrence of vaginal hyperplasia/prolapse?
ovariectomy will prevent recurrence
If the vaginal tissue is damaged, what surgical steps are taken to correct the vaginal hyperplasia/prolapse?
resect the prolapsed tissue at the base (via an episiotomy approach) and perform an ovariectomy
Treatment of choice for vaginal prolapse (very rare) is what?
Manual reduction and OHE
80% of vaginal neoplasia is benign and most commonly _______. Other benign vaginal neoplasia(s) are…
Leiomyoma - most common
Fibroma, polyps, and cysts
The most common malignant vaginal neoplasm is…
Others include…
Leiomyosarcoma - most common
TVT, TCC