Reproductive medicine Flashcards

Learn and revise reproductive medicine

1
Q

Ovulation marks the beginning of which phase of the menstrual cycle?

A

The luteal phase.

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2
Q

Which phase of the menstrual cycle varies between women?

A

The follicular phase. The luteal phase is relatively constant, lasting around 12 days.

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3
Q

The presence of which hormone is used as a test for pregnancy?

A

Human chorionic gonadotrophin (hCG).

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4
Q

Which cells of the testis have no counterpart in the ovary? They migrate from the mesonephros, contribute to the structure of the testicular cords and aid in spermatic movement?

A

The peritubular myoid cells.

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5
Q

True or false: the following is the definition of pre-eclampsia (pre-eclamptic toxaemia).

1) Reduced maternal BP
2) Proteinurea (0.5g/day)
3) Oedema

A

False on two accounts.

Firstly, maternal BP is RAISED - >140/90

Secondly, oedema is no longer part of the definition.

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6
Q

What is the only way of resolving pre-eclampsia?

A

Removal of the placenta

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7
Q

What is HELLP?

A

HELLP syndrome is characterised by Haemolysis, Elevated Liver enzymes and Low Platelets.

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8
Q

What causes pre-eclampsia?

A

Lack of remodelling of the spiral arteries.

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9
Q

True or false: the embryo is at most risk to teratogens during the first two weeks after fertilisation.

A

False. There is no susceptibility to teratogens during the first two weeks.

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10
Q

Which structures are formed from the mesoderm?

A

Bones, Muscles, Kidneys, Heart and Blood.

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11
Q

Gastrulation results in production of an embryo consisting of how many layers?

A

3, the endoderm, mesoderm and ectoderm.

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12
Q

Failure of neural fold closure at the cranial end leads to a child who has:

a) DiGeorge syndrome
b) Anencephaly
c) Spina bifida
d) Williams syndrome
e) Neurofibromatosis

A

b) Anencephaly if the neural folds don’t close at the top.

If the question asked about failure to close further down the spine, the answer would be c) Spina bifida.

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13
Q

Retinoic acid is one of the signals which controls activation of the Hox genes. From which vitamin is it derived?

A

Vitamin A

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14
Q

True or false: the Hox genes are responsible for development of the A-P axis.

A

True.

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15
Q

What are the five stages of lung development?

A
Embryonic
Pseudoglandular
Canalicular
Saccular
Alveolar

(Even practitioners can’t spell ‘Aubergine’)

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16
Q

Sonic hedgehog is the polarising factor of which signalling centre that controls limb patterning?

A

The zone of polarising activity (ZPA). The other signalling centre is the apical ectodermal ridge (AER). The FGFs encode AER activity.

17
Q

Thalidomide affects development of where in the body?

A

The upper limbs.

18
Q

If a mother takes lithium while pregnant, which mal-development can occur in the foetus?

A

Heart malformations.

19
Q

Amphetamine usage during pregnancy can lead to which facial deformity of the foetus?

A

Cleft lip and palate

20
Q

How long does each trimester usually last?

A

13 weeks.

21
Q

Oxytocin levels change during which part of labour?

A

During placental delivery. The oxytocin receptor, however, increases.

22
Q

What is the source of CRH in pregnancy?

A

The placenta

23
Q

Which two cytokines, upregulated by PAF, induce COX-2 activation from foetal membranes?

A

IL-1 and IL-6

24
Q

True or false: the ratio of PR-B to PR-A increases with labour

A

False, they decrease with labour.

25
Q

Spermatogenesis starts at which of the Tanner stages?

A

2.

26
Q

What is an ‘acrosome’?

A

An organelle, derived from the Golgi, which contains enzymes with which to penetrate the zona pellucida.

27
Q

How long does sperm development take?

A

74 days. It is therefore prone to to chemical exposure.

28
Q

What three parts of the epididymis do sperm travel through (in chronological order) and how long do they spend in the last part?

A

Caput: 1-2.5 days
Corpus: 0.5 days
Cauda: 5 days

Transit times are affected by sexual activity and impact on the quality of the ejaculate.