Reproductive Endocrinology

Question 1

lipid soluble hormones can travel freely in the blood - true or false?

Answer 1

false- they require a transport protein

Question 2

what kind of receptor do water soluble hormones bind to

Answer 2

cell surface GPCRs

Question 3

what kind of receptor do lipid soluble hormones bind to

Answer 3

intracellular receptor, activates receptor, hormone complex and alters gene expression

Question 4

what is the role of FSH in the male gonads

Answer 4

acts on the Sertoli cells, stimulating them to support developing germ cells, stimulates inhibin production required for negative feedback

Question 5

What is the role of LH in the male gonads

Answer 5

they act on the interstitial Leydig cells and stimulate the production of testosterone

Question 6

What is the role of FSH in the ovary

Answer 6

acts on the granulosa cells to stimulate follicle growth and produce oestrogen from androstenedione

Question 7

what are the roles of LH in females

Answer 7

LH surge stimulates ovulation and it also stimulates the production of androstenedione from cholesterol in the theca cells

Question 8

what are the actions of testosterone and 5-DHT

Answer 8

• stimulates spermatogenesis and prostate secretions
• secondary sex characteristics
• sex determination and genital development

Question 9

Actions of oestrogen and progesterone in females

Answer 9

oestrogen
- endometrial proliferation, genital development, secondary sex characteristics
Progesterone
- endometrial secretion and maintenance of pregnancy