Reproduction 6 - Male anatomy Flashcards

0
Q

What divides the scrotum into two halves?

A

septum of the scrotum.

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1
Q

What is the scrotum? Where is it? What is it a derivative of?

A

The scrotum is a cutaneous fibro-muscular sac for the testes and associated structures. It is situated posteroinferior to the penis and inferior to the pubic symphysis. The bilateral embryonic formation of the scrotum is indicated by the mid-line scrotal raphe, which is continuous on the ventral surface of the penis with the penile raphe.

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2
Q

What are the testes? What do they do?

A

The testes (testicles) are the male gonads. They are paired, ovoid reproductive glands that produce spermatozoa and male hormones, primarily testosterone.

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3
Q

Where are the testis?

A

The testis are suspended in the scrotum by the spermatic cords.

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4
Q

Describe the coverings of the testes

A

The surface of each testis is covered by the visceral layer of the tunica vaginalis, except where the testis attach to the epididymis and spermatic cord. The parietal layer of the tunica vaginalis is adjacent to the internal spermatic fascia, is more extensive than the visceral layer and extends superiorly for a short distance onto the distal part of the spermatic cord.

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5
Q

What is between the two layers of tunica vaginalis? Why?

A

There is a small amount of fluid between the two layers, in the cavity of the tunica vaginalis, allowing the testis to move freely in the scrotum.

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6
Q

What is the tunica albuginea?

A

A tough, fibrous outer surface, which thickens into a ridge on its internal, posterior aspect as the mediastinum of the testis.

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7
Q

Which part of the testes are sertoli cells associated with? What process are they involved in?

A

o Associated with Seminiferous Tubules o Spermatozoa development

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8
Q

What cells in the interstitial tissue secrete testosterone?

A

Leydig cells

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9
Q

In embryological development, where do the testes arise?

A

The testes arise in the Mesonephric ridge in the upper lumbar regions, at the lower pole of the kidneys

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10
Q

In the embryo, what are the testes tethered to and by what?

A

They are tethered to the labioscrotal folds, (Genital swellings, future scrotum), by the Gubernaculum.

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11
Q

Describe processus vaginalis

A

As the body grows, the relative position of the testis becomes more caudal. A musculo-fascial layer evaginates into the scrotum as it develops, together with peritoneal membrane to form the Processus Vaginalis.

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12
Q

What is the vestigial remnant of the gubernaculum called?

A

Scrotal ligament

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13
Q

Describe the venous drainage of the testis and why this is special

A

The venous drainage of the testes is asymmetrical. The veins emerging from the testis and epididymis form the Pampiniform Venous Plexus. This plexus is part of the thermoregulatory system of the testis, helping to keep the gland at a constant temperature. The veins of the plexus converge superiorly, forming the Right and Left Testicular Veins. The Right Testicular Vein drains into the Inferior Vena Cava (IVC) and the Left Testicular Vein drains into the Left Renal Vein. Testes –> Pampiniform Venous Plexus –> Right Testicular Vein –> IVC Testes –> Pampiniform Venous Plexus –> Left Testicular Vein –> Left Renal Vein The blood from the abdominal aorta is cooled as it passes through the testicular artery, as it is wrapped in the testicular vein.

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14
Q

Describe the blood supply to the testes

A

Arterial supply to the testes and epididymis is via the paired testicular arteries, which arise directly from the abdominal aorta. They descend down the abdomen, passing retroperitoneally and cross over the ureters and the inferior part of the external iliac arteries to reach the deep inguinal rings. The arteries then pass through the inguinal canal, emerging through the superficial inguinal rings and enter the spermatic cords.

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15
Q

Describe the structure and location of the epidymis

A

The Epididymis has a Head (Caput), Body (Corpus) and Tail (Caudal) segments. It is located on the superior and posterolateral surface of the testis.

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16
Q

What is the function of the epididymis?

A

The epididymis connects to the seminiferous tubule via efferent ductules and the rete testis. Its main function is sperm transport, maturation and storage.

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17
Q

Innervation of the testes

A

o Lumbar Plexus ▪ Anterior surface

o Sacral Plexus ▪ Posterior and inferior surfaces

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18
Q

Lymphatic drainage of the testes - why is it different?

A

o Testes ▪ Drains to paraaortic nodes o Scrotum ▪ Drains to superficial inguinal nodes Different drainage due to their embryological development

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19
Q

What is the ductus vas deferens, what does it do?

A

The Ductus Deferens (Vas Deferens) is a straight muscular tube that emerges from the caudal epididymis. It is contained within the spermatic cord and its main function is to transport the sperms rapidly to the prostatic urethra.

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20
Q

What feature helps the vas deferens to propel the tube’s contents towards the ejaculatory ducts?

A

Rich autonomic innervation of smooth muscle fibres of the ducts

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21
Q

The spermatic cord contains the structures running to and from the testes - what are they?

A

o Neurovascular

▪ Testicular Artery, Cremasteric Artery, Artery to Vas

▪ Pampiniform Plexus

▪ Genital branch of Genitofemoral Nerve

o Vas Deferens

o Lymphatics

o Processus vaginalis

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22
Q

Where does the spermatic cord run from and to?

A

It runs from the deep inguinal ring, lateral to the inferior epigastric vessels to the posterior border of the testis via the inguinal canal and superficial inguinal ring.

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23
Q

What are the seminal vesicles?

A

The seminal vesicles are two small glands that lie posterior to the prostate, between the bladder and rectum. The gland body consists of a single, highly convoluted tube that joins the ampulla of the ductus (vas) deferens to form the ejaculatory duct.

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24
Q

Where do the coverings of the spermatic cord come from? What are they?

A

The contents of the spermatic cord are mainly bound together by three fascial layers. They are all derived from anterior abdominal wall:

  • External spermatic fascia – derived from the aponeurosis of the external oblique.
  • Cremaster muscle and fascia – derived from the internal oblique and its fascial coverings.
  • Internal spermatic fascia – derived from the transversalis fascia.
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25
Q

What runs through the prostate?

A

The urethra

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26
Q

Name the zones or lobes of the prostate

A

The prostate is divided into anatomical lobes (inferoposterior, inferolateral, superomedial, and anteromedial) by the urethra and the ejaculatory ducts as they pass through the organ.

However, more important clinically is histological division of the the prostate into zones:

  • Central zone
  • Transitional zone
  • Peripheral zone
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27
Q

Outline the structure of the prostate

A

The gland is surrounded by a fibro-muscular capsule from which branching septae divide it into numerous small, but separate, compound alveolar glands from which excretory ducts originate and open independently into the prostatic urethra. The septae are characterised by discrete bundles of smooth muscle fibres interweaving with the connective tissues.

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28
Q

What do prostate secretions contain?

A

Prostaglandins, proteolytic enzymes and citric acid.

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29
Q

What volume of ejaculate is made up the the prostate?

A

~30%

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30
Q

What do bulbourethral glands do?

A

Just prior to ejaculation, these glands produce a clear water secretion that may lubricate the urethra

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31
Q

Where are the bulbourethral glands?

A

Enclosed within the fibres of the external urethral sphincter. They are situated posterolateral to the membranous urethra and superior to the bulb of the penis.

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32
Q

What type of glands do the bulbourethral glands contain?

A

Tubular and alveolar-type glands

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33
Q

Name three divisions of the penis

A

Root, body and glans.

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34
Q

What are the two internal structures of the penis?

A

Pair of Corpoa Cavernosa dorsally and a single Corpus Spongiosum ventrally.

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35
Q

Blood supply to the penis

A

Branches of the Internal Pudendal Arteries

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36
Q

Where does the internal pudendal artery originate from?

A

Abdominal Aorta –> Common Iliac à Internal Iliac –> Anterior Division of Internal Iliac –> Internal Pudendal Artery

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37
Q

Venous return from the penis

A

Cavernous spaces –> Venous Plexus of the Penis –> Deep Dorsal Vein of the Penis –> Prostatic Venous Plexus –> Internal Iliac Vein –> Inferior Vena Cava (IVC).

38
Q

What is the male perineum made up of? What do these do?

A

Ischiocavernosus – Compresses veins, therefore helps maintain erections. Bulbospongiosus – Helps to expel last drops of urine and maintain erections

39
Q

Outline sections of the male urethra

A

o Pre-prostatic ▪ Very short, neck of the bladder

o Prostatic

o Membranous ▪ Passes through the perineum and pelvic floor ▪ Least distensible ▪ Has the greatest risk of trauma due to catheterisation

o Spongy (or penile)

40
Q

Name some common clinical problems of the scrotum

A

o Haematocoele – Blood in tunica vaginalis

o Varicocoele – Varicosities of the Pampiniform plexus

o Spermatocoele – Retention cyst within the epididymis, aka epididymal cyst

o Epididymitis – Inflammation of the epididymal cyst

41
Q

What is a direct inguinal hernia?

A

▪ Hernia directly into the inguinal area ▪ Medial to the inferior epigastric vessels

42
Q

What is an indirect inguinal hernia?

A

▪ Hernia indirectly into the inguinal area, via the inguinal canal ▪ Lateral to the inferior epigastric vessels ▪ Reopening of the Processus vaginalis gives potential continuity between the peritoneal cavity and tunica vaginalis (abdomen –> scrotum).

43
Q

What is testicular torsion?

A

Twisting of the spermatic cord, giving the risk of necrosis of the testis. The twisting usually occurs just above the upper pole of the testis.

44
Q

Which structure lies on the postero-lateral border of the testis?

A

Epididymis

45
Q

The seminiferous tubules anastomose to form the ________________ posteriorly.

A

Rete testis

46
Q

A fluid layer in the cavity of the ____________________ allows the testis to move freely in the scrotum.

A

tunica vaginalis

47
Q

Where is the origin of the testicular arteries?

A

Aorta, just inferior to the renal vessels.

48
Q

The testicular veins arise from the ______________ plexus and drain into the _____________ on the right and the ____________ on the left.

A

pampiniform, IVC, left renal vein

49
Q

How may the cremasteric reflex be evoked and what does it demonstrate?

A

Stroking the superior part medial thigh evokes elevation of the testis on that side. This part of the thigh is innervated by the ilioinguinal nerve (L1); the genital branch of the genitofemoral nerve (L1, L2) innervates the cremaster muscle. Hence, a spinal reflex arc is demonstrated.

50
Q

Which smooth muscle layer causes the scrotal skin to wrinkle when exposed to cold temperatures?

A

dartos muscle

51
Q

Discriminate between the lymphatic drainage of the scrotum and that of the testis

A

The scrotal skin (fascia and tunica vaginalis) drains to the superficial inguinal lymph nodes whereas lymphatic drainage of the testis is via the spermatic cord to the para-aortic (or lumber) glands at the transpyloric plane, LI (hence, upper abdomen must be palpated). Further spread may be to mediastinal and cervical nodes.

52
Q

Explain why spread of malignancy from the testis to the cervical nodes of the neck is not uncommon.

A

Lymphatic drainage to para-aortic nodes, which anastomose with intra-thoracic and in turn cervical lymph nodes.

53
Q

The efferent ductules transmit sperm from the _________________ to the _____________________________.

A

rete testis, head of the epididymis

54
Q

Describe the course of the vas deferens.

A

Tail of epididymis, inguinal canal, side wall of pelvis close to ischial spine, then travels medially and joins with ducts from the seminal vesicle to form ejaculatory duct which joins the prostatic urethra, inferior to the bladder. (Hence, bladder, urethral and prostate infection may spread to the vas deferens here.) It is typically 45 cm long

55
Q

The spermatic cord commences superiorly at the deep inguinal ring lateral to the ____________________________ artery. Passing through the inguinal canal it terminates at the posterior border of the __________________.

A

inferior epigastric, testis.

56
Q

During vasectomy, the vasa deferentia are sectioned and ligated bilaterally from the superoanterior scrotal wall. What are the consequences to (a) the sperm and (b) the composition of the ejaculate (generally) after vasectomy?

A

a) Sperm degenerate in the epididymis and proximal ductus deferens, debris is removed by phagocytosis (b) The ejaculate is composed of secretions form the prostate, seminal vesicle, and bulbourethral glands only.

57
Q

From which layers of the anterior abdominal wall are the fascial coverings of the spermatic cord derived?

A

The double layer of the tunica vaginalis is surrounded by - Internal spermatic fascia (from transversalis fascia) - Cremasteric fascia (from fascial covering of the internal oblique) - External spermatic fascia (from the external oblique aponeurosis) These are followed by a layer of superficial fascia lying directly beneath the scrotal skin

58
Q

During descent of the testes, at what fetal month do they usually

reach the iliac fossa ………………… month

travel through the inguinal canal …….. month

reach the external ring …………….. month

enter the scrotum ……………………. month

A

3, 7, 8, and 9 months respectively

59
Q

What are the consequences of undescended testis?

A

infertility and potentially malignancy or testicular torsion, which remains elevated even after orchiopexy

60
Q

What are the contents of the spermatic cord?

A

Ducts: vas deferens, (and its artery) Vessels: testicular artery, cremasteric artery, pampiniform plexus of veins (surrounding the testicular artery), testicular lymphatic vessels Nerves: autonomic nerves, genital branch of the genitofemoral nerve,

61
Q

The smooth muscle of which structures contract in peristaltic waves during emission? How is this controlled?

A

Prostate, Vas deferens, seminal vesicles

Sympathetic control– hypogastric nerve (L1,L2)

62
Q

List the accessory glands of the male reproductive system, identifying the substances they secrete, the functions of such and the percentage volume of secretion the glands contribute to the semen (seminal fluid).

A

Seminal vesicles secrete an alkaline fluid that contains

(a) fructose (used in ATP production by the sperm), prostaglandins (facilitate sperm motility and may promote smooth muscle contraction in the female tract), and
(b) clotting factors, particularly semenogelin, (are proteins which help temporarily coagulate semen after ejaculation). Its alkalinity helps to neutralize the acid in the male urethra and female reproductive tract. 60% of volume of semen.

The prostate secretes a milky, slightly acidic fluid containing

(a) proteolytic enzymes (such as PSA, prostate-specific antigen, pepsinogen etc), which breakdown clotting proteins from the seminal vesicles, hence re-liquefying semen about 10-20 minutes after ejaculation
(b) citric acid, used by sperm in the Krebs cycle for ATP production
(c) acid phosphotase (unknown function) 25% volume of semen

Bulbourethral glands (Cowper’s glands) secrete an alkaline fluid to the urethra for acid neutralization (particularly neutralization of acid in the vagina), and a mucous that lubricates the end of the penis and urethral lining. These glands contribute a very small amount to the ejaculate.

63
Q

A prostate can grow to the size of an orange when enlarged but what is its usual size?

A

Chestnut or golf ball (3 cm round)

64
Q

Which part of the prostate gland is felt on rectal examination?

A

Posterior (median groove)

65
Q

Enlargement of which lobe of the prostate causes urethral obstruction?

A

Median (This may not be detected on rectal examination; the lateral lobes, however, are readily detected on rectal examination).

66
Q

The arterial supply to the prostate, the ______________, which is a branch of the ______________.

A

inferior vesical artery, Internal iliac artery

67
Q

Why is it that cancer of the prostate often presents later than benign prostatic hyperplasia (BPH)?

A

The cells that enlarge in BPH are close to the urethra, therefore causing a blockage of the urethra. Cancerous cells are more peripheral and therefore only occlude the urethra at a later, more advanced stage.

68
Q

How do levels of Prostate Specific Antigen (PSA) vary in BPH and carcinoma of the prostate?

A

BPH PSA normal/ slightly raised, carcinoma PSA markedly raised

69
Q

Explain why carcinomas of the prostate spread readily to the pelvis and vertebrae. (Hint : consider venous drainage)

A

Veins from prostatic venous plexus with dorsal vein of penis, drains into internal iliac vein. Some of the veins pass to a plexus in front of vertebral bodies and are valve-less, (valve-less vertebral veins of Batson) hence spread of malignancy.

70
Q

List the three parts of the urethra

A

prostatic, membranous spongy

71
Q

Which part of the urethra is least distensible and why?

A

Membranous, due to the surrounding sphincter urethrae muscle and perineal membrane

72
Q

Name the erectile tissue in the penis.

A

Corpora cavernosa Corpus spongiosum (glans penis is continuous with corpus spongiosum)

73
Q

Describe the arterial supply of the penis

A

Branches of the internal pudendal artery form : (1) the deep arteries (2) the dorsal arteries (3) the arteries of the bulb

(1) and (2) supply the crura and corpus cavernosa.
(2) and (3) supply the bulb and the corpus spongiosum

74
Q

Which fibrous capsule surrounds the corpora cavernosa?

A

Tunica albuginea

75
Q

During erection of the penis, venous engorgement occurs through vasodilation of the coiled (helicine) arterioles to the corpora cavernosa, hence increasing blood flow. What is the effect of the tunica albuginea and fascial sheaths?

A

These resist expansion, such that internal pressure rises and occludes venous drainage. Blood from the cavernous spaces drains into a venous plexus (which are compressed during erection), then into the deep dorsal vein. This, along with increased arterial flow, maintains rigidity of the penis for intercourse. (Venous return is also restricted by contraction of the bulbospongiosus and ischiocavernsosus muscles.)

76
Q

Whist the corpus spongiosum swells with blood, it does not become rigid. Why not and why I this important?

A

Whilst the tunica albuginea does surround the corpus spongiosum it is not as fibrous or restrictive as that which surrounds the corpora cavernosa. High pressure in the corpus spongiosum would occlude the urethra and hence prevent ejaculation of the semen.

77
Q

Predict what may happen, if the neck of the bladder (vesical sphincter) does not close during ejaculation?

A

Retrograde ejaculation into the bladder.

78
Q

The pudendal nerves carry afferent, sensory information from the glans to the CNS but which efferent outflow is involved in erection?

A

Pelvic nerve, parasympathetic (S2 - S4) , via inferior hypogastic plexuses promotes erection in erectile tissue, through relaxation of smooth muscle in the fibrous trabeculae and cooled arteries

Emission is sympathetically controlled. Ejaculation occurs via sympathetic outflow (L1 – L2) Hypogastric, sympathetic, involved mostly in depression of erection, by increasing myogenic tone in arterial smooth muscle.

79
Q

Which part of the penis is removed in circumcision?

A

prepuce (foreskin)

80
Q

List the causes of scrotal swelling?

A

Testicular torsion*; hernia, hydrocoele, epididymal cyst, epididymitis, orchitis, spermatocoele, varicocoele, a testicular mass and a cyst of the cord. A testicular torsion is the most important diagnosis, followed by testicular mass.

81
Q

Why must any scrotal swelling be considered as testicular torsion until proven otherwise?

A

The maximum time window from torsion to surgery is 12h. Thereafter most testes are unsalvageable and infertility occurs (other testes destroyed due to break down of blood testes barrier).

82
Q

Why does a lump in the testis of a 22 year old need follow up?

A

Any lump in the testis must be a suspected tumour. Testicular cancer is the commonest cancer that affects young men between the ages of 19 to 44 years old. Almost half of all testicular cancers occur in men under 35 years old

83
Q

In very general terms, how might you discriminate between a hernia and a swelling associated with the testis?

A

A hernia can be reduced then feel for normal scrotal contents.

84
Q

Which veins are dilated in a varicocoele? What does it feel like upon palpation?

A

The veins of the pampiniform plexus become dilated in the standing position. For reasons that are postulated rather than known; it occurs, almost invariably, on the left side and a right-sided varicocoele should always suggest malignant obstruction of the right testicular vein. On palpation it feels like a bag of worms.

85
Q

Describe the arterial supply to the testes & epididymis

A

Arterial supply to the testes and epididymis is via the paired testicular arteries, which arise directly from the abdominal aorta. They descend down the abdomen, and pass into the scrotum via the inguinal canal, contained within the spermatic cord.

86
Q

Describe the venous drainage of the testes and epididymis

A

Venous drainage is achieved via the paired testicular veins. They are formed from the pampiniform plexus in the scrotum – a network of veins wrapped around the testicular artery. In the abdomen, the left testicular vein drains into the left renal vein, while the right testicular vein drains directly into the inferior vena cava

87
Q

Predict why is a varicoceole almost always on the left? Why is a right sided varicocoele potentially worrying? Hint think about the venous drainage.

A

The left testicular vein empties vertically into the renal vein. much higher than the right drainage. The varicosities form when the valve system between these two veins fails and blood falls backwards under the pull of gravity. The right testicular vein drains directly into the inferior vena cava at an oblique angle, further down. Its valves do not have to support the same weight of blood as those in the left testicular vein and are therefore much less likely to fail. A right sided varicocoele is very uncommon and is suggestive of other, potentially more serious problems such raised IVC pressure - e.g. due to obstruction.

88
Q

What is a hydrocoele? Explain why hydrocoeles in young boys often get bigger when they cough (or cry)?

A

A hydrocoeles is usually a painless enlargement of the testis caused by accumulation of watery fluid, in a persistent processus vaginalis (tunica vaginalis) surrounding the testis. It can grow as large as a grapefruit! Hydrocoeles at this age are usually still connected to the peritoneal cavity by some persisting patency of the processus. The patency is limited so raised intra-abdominal pressure is required to send i.p. fluid through into the hydrocoele.

89
Q

Explain why trans-illumination with a small bright torch can distinguish an epididymal cyst from a spermatocoele.

A

An epididymal cyst contains clear fluid and transilluminates ‘brilliantly’, while a spermatocoele contains turbid fluid that inhibits transillumination. Epididymal cysts arise from unconnected segments of the efferent tubules that sprouted from the mesonephric duct hence the clear fluid content. Spermatocoeles arise similarly, but the segment is marginally connected to the rete testis and contains degenerate products of spermatogenesis. There is no important clinical difference between them, other than embryological origin.

90
Q

What is a haematoceole of the testis?

A

An accumulation of the blood in the tunica vaginalis (e.g., traumatic rupture of the testicular artery). If therefore does not transilluminate.

91
Q

Malignant spread from some testicular malignancies is primarily via ______which reflect the embryological origin of the testis from the _______and drain into ______.

A

Malignant spread from some testicular malignancies is primarily via lymphatics, which reflect the embryological origin of the testis from the posterior abdominal wall and drain into para-aortic lymph nodes.

92
Q

Why is a NMR very good and palpation very poor at assessing lymphatic spread from a testicular tumour?

A

Para-aortic nodes only become palpable when they are massively enlarged i.e. the patient already has a large tumour burden. NMR/ CT can detect nodal enlargement of 2cm or less and indicate that XRT or surgical ablation may be beneficial..

93
Q

Which zones of the prostate are the most vulnerable to a) BPH? and b) carcinomas?

A

a) transitional zone
b) peripheral zone