Reproduction Flashcards

0
Q

Which things affect onset of puberty in bitches?

A

Larger breeds show a later puberty than smaller breeds. Greyhounds may not start cycling until they are several years old. Most bitches enter puberty when they approach 80% of their expected adult weight. Physical signs are enlargement of the vulva, mammary gland development and start of oestrus cycling.

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1
Q

What is Puberty?

A

The time at which an animal shows physical and endocrinological changes which permit sexual function and the ability to reproduce. This is not a fixed time in bitches. Average age is 6-9 months but the range is 5-24 months.

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2
Q

What is monoestrus?

A

One oestrus cycle per phase. The bitch comes into oestrus once every 6 months on average. The 6 month interval is not exact and can vary from 4-12 onths.

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3
Q

What is a non seasonal oestrus cycle?

A

Oestrus cycles can happen at any time of the year.

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4
Q

What is spontaenous ovulation?

A

Mating is not necessary for ovulation to occur.

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5
Q

What is polytocous?

A

Pregnancy usually results in several young but single pup pregnancies can also occur.

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6
Q

Describe the length of oestrus in the bitch

A

There is no menopause in the bitch. The overall length of the oestrus cycle is the same whether pregnancy occurs or not. Fertility levels are low at the first oestrus cycle. If breednig, bitches should not be mated until after their third season as they are not fully mature until then.

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7
Q

What are the lengths of pro oestrus, oestrus, metoestrus and anoestrus?

A
Pro oestrus - 7-10 days> In season
Oestrus - 7-10 days  > In season
Metoestrus - 63 days
Anoestrus - 3-4 months 
The averagge season in the bitch is therefore 2-3 weeks in length. The male dog is attracted to the bitch from the start of pro oestrus but the bitch will not allow mating until the oestrus phase. Even quite home oriented bitches may stray when in season. PRegnancy lasts the same as metoestrus in bitches.
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8
Q

What are the behavioural and physical signs in pro oestrus?

A

Thin, blood stained vulval discharge, vulva swollen/turgid, repels ale, may roa, more frequent urination, oestrogen levels increased.

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9
Q

What are the behavioural and physical signs in Oestrus?

A

Discharge mucoid, less bloody, thicker, stands for male, vulva softer, tail deflection, may roam, oestrogen decreased, progesterone increased. Ovulation usually occurs 1-3 days after the onset of signs of oestrus

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10
Q

What are the behavioural and physical signs in metoestrus?

A

Possibly slight mammary enlargement, no specific signs unless false pregnancy, progesterone increases.

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11
Q

What are the behavioural and physical signs in anoestrus?

A

No specific signs, basal levels oestrogen and progesterone.

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12
Q

What is false pregnancy?

A

A progesterone driven hormonal phenomenon that occurs in all non pregnant dogs to a certain degree. some dogs show exaggerated signs to the extent of nest building, lactating, showing behavioural changes and even entering ‘labour’ it is not really an illness a such as should not be medicalised unnecessarily but it sometimes need treated especially if the bitch becomes aggerssive.

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13
Q

Describe puberty in the queen.

A

Usually 5-9 months but with a wide range of 4-18 months. Smaller and short haired breeds enter puberty sooner than larger rand long haired ones. Oestrus in the queen is dependent on increasing hours of daylight. the first oestrus is usually seen in the spring following birth.

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14
Q

Describe the oestrus cycle of the queen?

A

The queen is classified as being seasonally polyoestrus, polytocous, an induced ovulator. Seasonally polyoestrus means that the queen cat has repeated oestrus cycles throughout the breeding periods in spring, summer or autumn, unless she becomes pregnant. Compare this to the Monooestrous bitch who has single oestrus cycles every 6 months on average. This means that entire non pregnant queens come into season every 2-3 weeks approx. This starts in spring and ends in late autumn. If a pregnancy has occured, the cat re enters oestrus after weaning of kittens at 4-6 weeks or sometimes even when lactating. She could then become pregnant again.

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15
Q

What are the behavioural signs of pro oestrus & oestrus in the queen?

A

Affectionate, writhing and rolling around, vocalizing, when stroked, crouches with hind quarters elevated, neighbourhood entire toms likely congregating.

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16
Q

What are the behavioural signs of inter oestrus and anoestrus in the queen?

A

Lag phage - no behavioural signs, lasts approx 1-2 weeks, during spring, summer and early autumn and also continues throughout late autumn and winter until photoperiod lengthens again (anoestrus). Some cats cycle continuously in response to artificial light, and a few breeds e.g the sphinx have twice yearly seasons like dogs.

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17
Q

What is induced (reflex) ovulation in the cat?

A

Spines on the tom cat’s penis > coital stimulus to ovulate. Induced reflex ovulation means that queens require a mating stimulus (the backwardly directed spines or papillae on the toms penis) to achieve ovulation. Ovulation occurs 24 hours after mating in response to an LH surge. Again this is different from the bitch who ovulates spontaneously. Pregnancy in the cat is approx 63 days.

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18
Q

Describe puberty in the dog and tom

A

Puberty is 6-12 months, later in larger breeds of dogs especially. Testicles are normally in the scrotum at birth or soon after. If the testicles are not present at 12 weeks a diagnosis of cryptorchidism should be made. A retained testicle is unlikely to descend on its wner after this age. It is extremely unusual for a dog or tom to only have one testicle so it must be assumed the missing testicle is retained. Retained testicles have a higher risk of neoplasia and of problems such as testicular torsion so they should be located and removed. This may require laparotomy although many are found subcutaneously in the inguinal region. dogs and toms generally remain fertile into old age.

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19
Q

Describe breeding of dogs and cats

A

No nherent beneit in letting dogs mate - does not alter temperament. Pregnancy s not without risk. Delay breeding until it is known that the dog or cat is physically and temperamentally sound. Dogs have to be 1 year old before they can pass hip dysplasia scheme. Blood type should be ascertained in some pure breed cats. They should be FeLV and FIV negative. Animals for breeding should be healthy, of good temperament, free from physical defects, cryptorchidism, jaw malocclusions, treated for parasites, innoculations and a pre mating veterinary exam.

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20
Q

Describe mating in dogs

A

Sucess is more likely if one of the pair have been mated successfully several times before. human intervention should be kept to a minimum. Bitch will not accept male in pro oestrus and may be aggressive. Do not persevere if she will not stand for the dog Matins best repeated every 48 hours until oestrus ends i.e a one off visit to the dog to the bitch is less likely to be Sucessful than the dog residing with the bitch for a few days.

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21
Q

Describe the typical pattern of mating events ni the dog

A

Initial jumping ana dplayful chasing behaviour > dog sniffs/licks vulva of bitch and may attempt mounting (bitch will stand still if in oestrus with tail tdeflected, wil reject dog if still in pro oestrus) > dog penile extrusion and erection occurs. Dog mounts bitch and intromission achieved (inexperienced dogs may need help here) thrusting movements occur for a few minutes > the tie then occurs as the dog steps over the bitch and both parties are then locked rear to rear. This lasts up to 30 mins and is produced by the bitches vaginal muscles encircling the dogs bulbus glandis. Bitches can conceive without a tie phase as the sperm rich fraction of the ejaculate is produced before the tie. so accidental matings without a tie can still result n puppies.

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22
Q

Describe the mating in cats

A

The queen should be taken to the tom as the tom may have reduced libido in a new environment for up to 1 month. A maiden queen, even in full heat, may not accept the tom and the first mating is often forced upon her by the tom thereafter she participates more willigly. Mating is preceded with courtship behaviour, with prowling and howling etc. The queen adopts the mating position with the front end crouched and the hind end raised with the tail deflected. the tom mounts so that his body lies over her back and bites her scruss. Intromission and ejaculation occur quickly - there is no tie.

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23
Q

Describe the best age for breeding in the bitch and queen

A

Bitches should not be bred at their first oestrus as they are neither physically nor temperamentally mature. Ideal earliest age for breeding is at third oestrus or two years of age. Older bitches have increased risk of complications. Do not breed when over eight years of age. Most unspayed cats will have early first pregnancies. Ideal planned breeding is around 19 months for first pregnancy. should be retired at about 5-6 months age.

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24
Q

How can pregnancy be detected in the bitch?

A

Palpation of abdomen after 4 weeks of mating, at 7 weeks obviou foetuses can be felt. Auscultation of abdomen in last 2 weeks of pregnancy. Mammary enlargement from 5 weeks onward.s Mucoid vulval discharge from 4 weeks onwards. Ultrasound from 4 weeks onwards. X rays from 6 weeks - should not be used routinely. Relaxin assay - from 4 weeks in bitch. Hormone produced by placenta. Oestrogen/progesterone levels are not useful in determining pregnancy in the bitch or queen.

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25
Q

Describe normal parturition

A

Gestation is approx 63 days. Mammary gland hypertrophy begins at around half way through the first pregnancy term, and in the last 2-3 weeks in subsequent pregnancies. Milk may be expressed 1-2 days before parturition. Thee vulva becomes enlarged and flaccid shortly before parturition. Nestmaking activities start shortly before. Many cats disappear to give birth and choose their own space. Temperature fluctuates in the last week with a sharp fall of 1-2 F. 12024 hours pre partum. Litter size aries from often one in miniature dog breeds to more than 12 in giant breeds. Cats have 1-9 kittens (usually 3-5). Parturition or labour is divided up into three characteristic stages.

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26
Q

Describe stage 1 labour?

A

Lasts from 6-12 hours or longer in the first parturition. This phase is characterised by a fall in rectal temperature. Drop in body temp, vagina relaxes, cervix opens, minor uterine contractions commence, restless, panting (bitches), nesting, washinng, vocalising (queens).

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27
Q

What is stage 2 labour?

A

Stage 2 - active abdominal straining in lateral recumbeny or crouching position; foetuses move into pelvic canal and are delivered. There are natural pauses between delivery of individual puppies and kittens. Overall length of stage 2 depends on how many yougn are preent. Stage 2 can occasionally last up to 24 hours and still be normal but is most usually over within 4-6 hours.

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28
Q

Describe the delivery of the neonate?

A

The allantochorion ruptures within the vagina and produces clear fluid seen at vagina which the bitch will usually lick. the amniotic sac/membrane is usually the first structure seen externally and the neonate is born enclosed in this. Usually the dam will lick, ibble and break the amniotic sac and also bite the umbilical cord and lick the neonate before allowing it to suckle.

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29
Q

What is stage 3 labour?

A

Placental separation around birth of first feotus results in a discharge, dark green in the bitch, reddish brown in the quene. This discharge is termed utero verdin and is normal. the placenta of each foetus is usually expelled 5-15 mins after its birth and the uterine horns shorten although sometimes 2-3 foetuses may be born before their placentas follow. The dam usually attempts to eat placenta and stillborn foetuses.

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30
Q

What is dystocia?

A

Dystocia is an abnormal labour or parturition with complete impediment or prolongation of birth. Consequences include dead foetuses and illness or death of the dam.

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31
Q

What are the signs of a dystocia being present?

A

Prolonged first stage labour without progression to second stage. Temperature drop then return to normal temp with no signs of parturition. Persistent vigorous and unproductive staining of stage 2 labour for 30mins - 1 hour. Weak, irregular straining for >2-4 hours. Delay of >2 hours since rupture of allantochorion but no foetus produced. Delay of > 2 hours since birth of last foetus and more known to remain. Dark green or reddish brown discharge but no foetus born within 2-3 hours. Foul smelling vulval discharge. Second stage labour > 12 hours. Vomiting if repeated or protracted.

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32
Q

Describe uterine inertia?

A

Commonest reason for dystocia. the uterine is inert and fails to contract so pups are not expelled. Primary inertia: myometrium lacks or becomes unresponsive to foetal movement stimulation. Caused by 1 single pups which fail to provide sufficient physical stimulation of the uterus to provoke contractions or by very large litters leading to over stretching of the myometrium and eventual desensitisation. Labour does not begin or progress to stage 2. Foetal death if no action. Secondary inertia: signs of labour are evident but the myometrium eventually becomes exhausted and unresponsive. This can be caused by obstructive dystocia very prolonged labour, weak or old obese bitches.

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33
Q

What is the treatment for uterine inertia?

A

Gentle ecercise of the dam may provoke uterine activity. Not applicable with seondary inertia. Fergusion reflex - tactile stimulation of the dorsal vagina may provoke contractions. Oxytocin injection stimulates smooth muscle contraction in the uterus by initiating calcium uptake. When given intramuscularly it is usually effective within 5 minutes. Can be repeated after 30 mins if a foetus is delivered but more remain. Use of oxytocin is contraindicated in obstructive dystocia where uterine contraction against a blockage caused by a trapped foetus could result in rupture.

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34
Q

What are the foetal causes of dystocia?

A

Oversized foetus -a problem in small litters e.g the giant single puppy. Malpresentations - configuration of foetus relative to birth canal precludes delivery. Single pup syndrome - seen in small breeds. Pregnancy may go unnoticed until late in term. Cause of primary uterine inertia due to lack of stimulation of myometrium. the problem may be inherited. Foetal oversize and dystocia may also result. One huge puppy and obstructive dystocia.

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35
Q

When should you opt for a caeserian?

A

When uterine in inertia is not responsive to medical treatment i.e two treatments with oxytocin. When obstructions are not safely correctable by manipulation. natomical abnormalities in the dam or foetus preclude delivery (commonly pelvic narrowing due to fracture or foetal malformations). Foetal death with putrefaction has occured. the dam is ill: the risks far outweigh anaesthesia risks compared to risk of the dam deteriorating and undergoing sepsis from putrefying foetuses.

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36
Q

Describe reproductive endocrinology

A

Oestrogen rises throughout pro oestrus and peaks 2 days before the LH surge, declining through ovulation and oestrus, rising slightly again at the end of the luteal phase. Progesterone is basal through prooestrus and starts to increase at the time of the LH surge (luteinisation of Graafian follicles occurs before ovulation), staying elevated for approximately 9 weeks, before declining at Anoestrus or parturition. Ovulation of primary oocytes occurs 2 days after the LH surge and it takes a further 2 days for the eggs to mature before they become fertilisable. There is little difference between oestrogen and progesterone concentrations between pregnant and non pregnant bitches. Prolactin is produced by the anterior pituitary from day 25 in response to decreasing progesterone. It is luteotrophic and supports the CL to keep progesterone levels high in pregnancy. Prolactin is still produced in non pregnant bitches but usually at lower levels.

37
Q

Describe the hormone levels and clinical signs in the non pregnant bitch during pro oestrus?

A

Developing follicles produce oestrogen which causes signs of firm vulval swelling; thin, faintly bloody discharge and perhaps increased squatting and urination. The bitch in pro oestrus is interested in male dogs but she will not stand for mating and may repel any hopeful male dogs.

38
Q

Describe the hormone levels and clinical signs in the non pregnant bitch during oestrus?

A

oestrogen levels decline and progesterone levels rise from luteinisation of follicles, which occurs before ovulation; vulval area softens; discharge less bloody and thicker, the bitch in oestrus will stand for the male with tail elevated or deviated, she may roam searching for a suitor even if normally a home bird. Ovulation usually occurs 1-3 days into oestrus.

39
Q

Describe the hormone levels and clinical signs in the non pregnant bitch during metoestrus?

A

Progesterone dominated luteal phase of cycle which persists until corpus luteum regresses, no outward signs except perhaps some mammary development. This is the phase of the cycle when false pregnancy or pyometra may occur. Progesterone levels are elevated regardless of whether or not pregnancy has occured.

40
Q

Describe the hormone levels and clinical signs in the non pregnant bitch during anoestrus?

A

Ovaries inactive, basal levels of oestrogen and progesterone, the quiescent phase of the cycle, with no clinical signs and the time when female dogs should be spayed.

41
Q

Describe the hormonal changes that occur during oestrus cycle and pregnancy in the queen?

A

Oestrogen levels are high through pro oestrus and oestrus and bring about the marked behavioural changes seen at this time. Coital stimuli produce an LH surge and reflex or induced ovulation although some cats can ovulate spontaneously. Progesterone levels rie after ovulation and remain elevated throughout pregnancy. If no ovulation occurs, an interoestrus period of 10-14 days occurs between seasons, where the queen hows no behavioural signs and oestrogen levels are basal. Some cats have a much shorter Interoestrus period and may appear to cycle continuously. Prolactin rises in the last 1/3 of pregnancy and during lactation but not in the feline pseudopregnant state.

42
Q

What are the hormone levels and clinical/behavioural signs in the non pregnant queen?

A

Pro oestrus / oestrus - cats exhibit few outward signs of pro oestrus. The behavioural signs are marked. cats in eostrus more friedly, very vocal, roll and writhe around, may crouch with hind end elevated, make deep throaty noises, un neutered toms will congregate in vicinity. Interoestrus and anoestrus - none of the above behavioural signs are present and oestrogen levels are low.

43
Q

What is delayed puberty?

A

In bitches, puberty normally occurs at 6-9 months old but it can range from 5-24 months. Large and giant breeds attain puberty later than small and medium breeds. some greyhounds may not start cycling until 4-5 years old. Explain to concerned clients that 6-9 mths is not a definite cut off point for the first oestrus. Sometimes the first oestrus is short with a few outward signs and may be msised. Can measure progesterone to see if the bitch has had an unnoticed heat. In queens puberty normally occurs at 5-9 months but can range from 4-18 months. Usually queens have their first season in spring following bith and when over 2.5kg.

44
Q

What is prolonged anoestrus?

A

Primary anoestrus - never had a season. Secondary anoestrus - had one normal or abnormal season then a period of anoestrus. In bitches mostly due to inadequate observation or lack of display of oestrus sigs due to individual variability. Greyhounds and whippets have very little vulval swelling. Can measure progesterone to see if ovulated in past few months. In queens, cessation of cycling can be due to sterile mating or spontaneous ovulation inducing luteal phase - cycling should then resume in around 40 days. Day length also important. need around 14 hours light a day to cycle. Systemic disease, malnutrition, thyroid disease, ovarian cysts, ovarian neoplasia, prior progestogen therapy and stress can cause cessation of cycling.

45
Q

What is a silent heat?

A

No external signs of season or very vague or intermittent signs are seen. In bitches can use progesterone assay to ascertain if ovulated then predict when next season is due and use vaginal cytology to assess season. Possibly inherited. in queens can occur at those low end of social scale in multicat household or cattery.

46
Q

What is a split season or split pro oestrus?

A

most common in young bitches and queens. Owners of bitches often report that she has had two heats close together. Pro oestrus begins with discharge evident in bitches but follicular development is inadequate and signs of season subside without ovulation. This is referred to as a false heat i.e nothing comes of it. 2-12 weeks later in the bitch or a few day later in the quen, pro oestrus starts again and a normal season occurs or sometime another false heat.

47
Q

What is prolonged juvenile pro oestrus?

A

In bitches commonly occurs at first season and is not considered abnormal at this age. It would be abnormal in mature bitches when pro oestrus and oestrus rarely exceed approx three weeks. Can have pro oestrus lasting for up to 40-50 days in the pubertal bitch. Thought to be due to inadequate LH Surge. Usually resolves spontaneously after 6-7 weeks. Main problem is inconvenience from persistent discharge and attention by male dogs. Can be caused uncommonly by oestrogen secreting follicular cysts or ovarian tumours in older animals. If persistent can cause bone marrow suppression. In queens, the interoestrus period can be extremely short or non existent due to waves of follicular growth following on from one another. The cat appears constantly in season - t his can be awkward when trying to time the spay operation and often results in cats being spayed when in season which is the usual treatment.

48
Q

What is a false pregnancy?

A

Socially beneficial in natural groups of canids. False pregnancy has become medicalised because of some of the extreme signs shown by some bitches. FP can occur in any entire bitch. mating is not necessary. FP tends to re occur in those bitches Which show exaggerated signs. Breeding does not stop FP from occurring in the future. Progesterone levels are maintained in the luteal phase in both pregnant and non pregnant bitches by luteotrophic action of prolactin on the CL. PRolactin promotes milk production and behavioural changes in pregnant and pseudopregnant bitch. All non pregnant bitches have prolactin production; it is part of the normal endocrinoology of metoestrus. Signs commence 6-8 weeks after oestrus just before a pregnant bitch would whelp. Mammary hypertrophy, lactation and sometimes mastitis, vulval discharge, adoption and protection of toys, anorexia and mournfulness, aggression, nesting behaviour.

49
Q

What is the treatment for false pregnancy?

A

do not treat mild and transient signs they are normal and self limiting. for bitches where the symptoms are persistent or severe or manifesting as aggression use cabergoline. This inhibits prolactin production by its action on the anterior pituitary dopamine receptors. Prolactin falls and proesterone declines > luteal phase ends > anoestrus begins > dog behaves normally. oral dosing daily for 4-6 days. Response within a week usualyl.

50
Q

Which other drugs may be used for treatment of false pregnancy?

A

Proligestone: exogenous progestogen administration inhibits prolactin since prolactin produced in Response to falling endogenous prgesterone.
Androgen/oestrogen - such as serosal inhibit prolactin. Not frequently used now.

51
Q

when should you spay bitches prone to FP?

A

ovariohysterectomy during a FP causes a rapid fall in progesterone, which stimulates prolactin secretion to restore progesterone levels. this can result in maintenance and prolongation of the FP. A similar effect can be seen if a bitch is spayed in the luteal phase even when they are no sign of FP. For this reason bitches should always be spayed when in anoestrus i.e 3 months after their season. Should a FP develop after spaying it can be treated with cabergoline.

52
Q

Describe false pregnancy in queens?

A

If a queen has mated and ovulated but not conceived, a luteal phase equivalent to FP will occur with progesterone levels elvated though they are lower than in pregnancy. This lasts about 6 weeks and is normal. Behavioural signs are not seen as in bitches but some queens will lactate . Some of these show massive mammary enlargement known as mammary hyperplasia. Superficially this dramatic and fairly common condition can resemble extensive mammary neoplasia and may be misdiagnosed as such. Mammary hyperplasia can also follow progestogen use. Treatment is spaying in young cats, withdrawing progestogens and waiting for the glands to return to normal.

53
Q

What are the treatment options for misalliance/mismating?

A

allow pregnancy
Surgical treatment: early spay once oestrus ends. May be the best course when spaying is anyway intended. Medical termination of pregnancy: Progesterone antagonists such as aglepristone. Block uterine progesterone receptors. Blood progesterone levels are unaltered. Canb e used up to 45 days into gestation. Two injections given 24 hours apart. Best given in first three weeks after mating. Later administration will cause abortion of foetuses c.f resorption. Oestrus returns in less than 6 months. Oestroens used to be commonly used to terminate pregnancy. Prolactin inhibitor cabergoline wil lead to reduced progesterone and pregnancy termination. Drug is not currently licensed for this used so should not be used under cascade rules.

54
Q

How can suppression of oestrus be done pharmacologically?

A

Proligestone - a depot progestagen used to terminate post pone or suppress oestrus. Currently the drug of choice. Licensed for both dogs and cats. Permanent suppression - injections at 3,4 and every 5 months in dogs.

55
Q

What is juvenile vaginitis?

A

Common in bitches from 2-3 months of age. Purulent vaginal discharge seen but there are no outward signs of ill health. Some itches may lick the vulval area clean. the discharge is produced by vaginal glands and will probably contain commensal bacterai. antibiotics are not indicated or successful. Only treatment indicated is periodic bathing or wiping away of discharges. Bitches with this condition should be allowed to have a season before spaying.

56
Q

What is adult vaginitis?

A

A persistent vaginal discharge usually in a bitch having had atleast one season. Does not produce signs of systemic illness. Pregnancy neoplasia and anatomical problems are ruled out by examinations. Antibiotics and local treatment is the treatment for bacterial vaginitis. Swabs may be used for culture and sensitivity testing.

57
Q

What is perivulval dermatitis?

A

USually seen in obese bitches, those with urinary incontinence or in patients with infantile vulva, where the vulva is small and recessed. Dermaatitis with licking and superficial infection around the vulva occurs. Treat with topical and systemic antibiotics. Surgery may be indicated in severe or recurrent cases o those with anatomical problems of infantile vulva.

58
Q

What is intersexuality?

A

Can present in a variety of ways, most commonly as an enlarged clitoris when the structure can contain bone. Can be caused by administration of progestogens to pregnant bitch. Treatment is to neuter patient but clitoridectomy may also be required. rare in cat.

59
Q

What are ovarian cysts?

A

Paraovarian cysts arising from paraovarian bursa are endocrinologically inactive and a common incidental finding at spay. they may also be present on the uterus. Such bitches would cycle normally with these non functional cysts. Ovarian cysts can either be follicular or more rarely luteal. Follicular cysts are usually seen in older animals and produce oestrogen. the main sign is prolonged pro oestrus probably caused by a failure of LH secretion. Ovariohysterectomy is treatment of choic. Luteal cysts are rare and produce progesterone. this continues for many months. Bitch does not return to season as expected.

60
Q

Describe granulosa cell tumours

A

Most commonly occurring ovarian tumour, usually seen in older bitches and also seen in queens. Can become very large and often produce signs because of their space occupying nature. Usually endocrinologically inactive but can produce oestrogen (persistent oestrus, bone marrow suppression) or progeterone (acyclicity and cystic endometrial hyperplasia/pyometra). Diagnosis by physical exam and imaging. Do not commonly metastasise but care needed when removing them by ovariohysterectomy not to seed tumour cells throughout the abdomen.

61
Q

Describe cystadenoma, cystadenocarcinoma and fibromas.

A

Rarer. Usually present as an abdominal space occupying lesion with associated symptoms. Adeocarcinomas can metastasize and may result in signs from the target organ of metastasis. Treatment is by ovariohysterectomy.

62
Q

What is pyometra treatment?

A

The treatment for this condition is ovarihysterectomy. Medical treatment with prostaglandin f2a is possible but not recommended as has disadvantages and implications for the welfare of the individual bitch or queen. Medical treatment for pyometra should be rare.

63
Q

What are the differentials for an infertility case which has never been in season?

A

Sex is male, female is spayed, poor observation, overt signs not displayed in individual females, not reached puberty, systemic ill health, stress, severe malnutrition, anatomical reproductive tract abnormalities.

64
Q

What are the differentials for an infertility case which has had seasons but now apparently stopped?

A

Poor observation, reproductive tract disease, systemic disease, malnutrition or stress, spayed, iatrogenic - drug administration e.g proligestone altering cycling.

65
Q

What are the differentials for an infertility case which has persistent signs of oestrus?

A

Split seasons, prolonged pro oestrus, functional ovarian cysts, iatrogenic, oestrogen administration, normal in some queens with very short inter oestrus periods.

66
Q

What are the differentials for an infertility case which has failure to conceive after normal oestrus?

A

Not given sufficient opportunity to mate not left long enough with male, poor observation regarding best time for mating, male is infertile, sub clinical disease or stress in male or female, failure of ovulation in female, anatomical problems in UG tract.

67
Q

What is the optimal mating timing in bitches determined?

A

Genuine infertility rare. Finding optimal time is best left to nature. Most infertile bitches are so because mating has not occured at the right time. Very easy to get wrong as external signs vary etween individuals and even when obvious they do not always correspond well with hormonal changes and the most fertile period. Some dogs clean fastidiously. Many of these bitches would conceive i they had repeated access to the male dog over a period of some days rather than having a pre ordained mating appointment.

68
Q

Describe the fertilisation period?

A

The fertilisation period is when the egg is capable of being fertilised by the sperm. In the bitch the LH surge is followed 2 days later by ovulation of primary oocytes, which take a further 2 days to mature and become fertilisable. They ca then survive in the tract for a number of days after maturation. Therefore endocrinologically the fertilisation period is around 4-8 days after the LH surge and 2-6 days after ovulation.

69
Q

What is the fertile period?

A

The fertile period is the time when a mating can result in a pregnancy It includes the fertilisation period and precedes this due to sperm survival in the reproductive tract. Good quality sperm can survive up to 7 ays. Therefore a bitch could get pregnant if mated five days before ovulation. Potentially there can be around a 10day fertile period but there will be variation.

70
Q

how is ovulation timed in bitches?

A

Between individual bitches there is a huge variation in the timing of ovulation after the onset of pro oestrus. On average it is around 12 days after the onset of proestrus., but in some bitches can be as little as 3 days or as much as 30. If mating takes place on day 12 but ovulation occurred on day 5 then fertilisation won’t occur.

71
Q

How can ovulation in bitches be predicted?

A

Clinically - 4 days after the onset of vulval softening and the bitches first inclination to stand for the dog. Unreliable. Hormonally - no LH assay and surge can be over in a few hours. Progesterone produced before ovulation from Graafian follicle luteinisation and continues after it. Correlates with LH surge. Can be assayed in house. requires repeated testing every 48 hours to detect the progesterone rise before ovulation. A moistened swab can be stained with diff quick and repeated every 2 -3 days, oestrogen makes vaginal mucosal thicker with larger cells and more layers and the cells lose their nuclei and become cornified.

72
Q

Describe infertility in the queen

A

Rare, often due to ovulation failure from not enough matings and not ing mated on the right day. Remember that the queen is a reflex ovulator and needs coital stimuli to produce an L surge and ovulation. Taking a queen to a stud cat for a short one off mating visit can be a recipe for failure. Leaving them together often solves problem.

73
Q

Describe infertility in the queen caused by insufficient LH to cause ovulation;

A

too few matings - common - allow multiple matings to take place. Mating on the wrong day - matings on day 1 of oestrus give a greater LH surge than any other day. A lot o breeders take queens to stud on day 2 after they have observed behavioural signs of oestrus.

74
Q

How can cycle length be used as a predictor of ovulation in cats?

A

Cycle length can be used to tell if ovulation has occured and therefore if inadequate mating is the cause of infertility. ensure more matings especially on day 1
>21days: ovulated and cat is either pregnant or pseudopregnant therefore mating is not the cause > need to investigate other problems.

75
Q

Describe resorption of the embryo/foetus?

A

Difficult to quantify since likely unnoticed. Mating without a pregnancy has other causes, usually poor timing of mating or insufficient opportunity. Causes of resorption could be abnormalities in the embryo, uterine space competition, infection, iatrogenic, no treatment is indicated unless the bitch is unwell.

76
Q

What is abortion?

A

Expulsion of a non viable foetus or one incapable of independent life. Death i utero may result in a dead foetus being carried to term and born with live ones. common causes are foetal defects, trauma, ifections, toxins, disease or stress in the dam. following suspected abortion, an ultrasound scan can be used to check the viability of any remaining foetuses. On xray the presence of ga and abnormal bone conformation indicate foetal death. A dam encountering abortion should be treated with iv fluids and oxytocin to encourage expulsion of the non viable foetuses. No attempt should be made to arrest the abortion by giving progestogens. Endotoxaemia could result. Swabs and tissue samples from foetal membranes and serology from the dam - establish a diagnosis.

77
Q

Name the infectious causes of abortion in the bitch?

A

canine herpes virus, distemper virus, adenovirus, parvovirus, brucella canis, toxoplasma gondii.

78
Q

Name the infectious causes of abortion in the queen?

A

Feline leukaemia virus, feline panleukopaenia virus, feline herpes virus, FIP virus, toxoplasma, chlamydophila felis.

79
Q

What are the infectious causes of abortion in the bitch?

A

Most causing abortion are routinely incorporated into standard vaccines which afford protection, distemper, adenovirus and parvovirus and therefore now rare causes of abortion in place. Canine herpes virus infection can cause early foetal death and resorption, abortion and premature birth. A vaccine is available and is given during oestrus or shortly after mating with a booster. Brucella canis is not present in the Uk but could be seen imported dogs. It usually causes late abortion and the most common route of spread is venereal. Toxoplasma gondi is a rare cause in the bitch, can cause abortion, premature birth and weak non viable neonates.

80
Q

Describe the infectious causes for abortion in cats?

A

Vaccination is possible for FeLV, feline panleucopaenia and feline herpes and each of these may cause abortion. Testing for FeLV and herpes should be performed before any planned breeding. FIP may cause abortion and fading kittens - a fairly generic term for poorly kittens that do not thrive. Toxoplasma and chl. felis may be associated with abortion.

81
Q

Describe habitual or recurrent abortion in bitches and queens?

A

Largely anectodal diagnosis, non specific. Refers to bitches and queens which abort a number of times. Careful documentation reproductive history required. Uterine or placental disorders could cause habitual abortion e.g cystic endometrial hyperplasia. this would be the main cause of genuine recurrent abortion. Progestogens should not be used in an attempt to prevent this. There is no convincing evidence that a real condition of progesterone insufficiency exists to explain habitual abortion.

82
Q

What is a uterine torsion/rupture?

A

seen in late pregnancy or during parturition when the uterus is at its most distended. Rupture can be caused by blunt external trauma, uterine torsion or incorrect use of ecbolics. Torsion can occur spontaneously of unknown cause and is commoner in dogs. In both rupture and torsion the dam presents with shock/collapse, pain and haemorrhage. ruptured uterine contents in abdominal cavity may be seen on ultrasound or x ray. there will likely be signs of generalised peritonitis. Stabilise patient as far as possible with i.v fluids and shock therapy and perform emergency ovariohysterecotmy.

83
Q

what is eclampsia?

A

also called lactational tetany, post partum hypocalcaemia and puerperal tetany. A medical emergency affecting smaller breeds more than larger. usually occurs after birth within the first 2-3 weeks but will be seen before occasionally. Rare in cats. Calcium losses in milk exceed bitches ability to maintain calcium homeostasis > clinical hypocalcaemia. early signs: agitation, restlessness, pacing and panting, salivation, jerky gait, trembling. Worsening: pyrexia, tonic clonic muscle spasms, tachycardia, seizures. Late life threatening; collapse, coma, death.

84
Q

What is post partum metritis?

A

Toxic state ensuing after abortion, dystocia or foetal/placental retention. bacterial infection of the womb, ascending infection, pyrexia, lethargy, anorexiia, vomiting, vaginal discharge. Diagnosis largely made clinically, confirmed by ultrasound if available and or X ray. Treatment is stabilisation with iv fluids, iv antibiotics, oxytocin then spay.

85
Q

What is post partum haemorrhage?

A

Can be caused by trauma during parturition or placental necrosis. Oxytocin causes uterine involution and improves most cases. supportive treatment may be needed. Spay in severe cases where major damage suspected.

86
Q

What is placental retention?

A

Sometimes suspected but rare in small animals, more likely placentas have been eaten, continued discharge (green colour, uteroverdin) and possibly metritis may occur in genuine cases. Best diagnosed with ultrasound. Treatment would be supportive, antibiotics, oxytocin.

87
Q

What is agalactia?

A

No milk flow in an otherwise normal mammary gland. Failure of milk production is rare, more likely failure of let down, which is under neuro hormonal control. Inexperienced and nervous bitches may be prone, rarely seen in queens. Usually maternal drives and instincts kick in when puppies attempt to suckle. the bitch should be left in a quiet place with the puppies, away from the people and not continually disturbed. Low doses of oxytocin may be given in very agitated and nervous bitches a mild sedative may be tried.

88
Q

What is galactosis/mammary congestion?

A

Mainly dog disease associated with failed milk let down and be part of agalactia. Warm, turgid mammary glands, painful to touch, caudal glands most affected. Differential = mastitis. Mastitic glands feel lumpier this condition can develop into mastitis. Gentle massage and encouragement of suckling by pups will help. If occurs near the end of lactation can prescribe cabergoline and wean puppies.

89
Q

What is Mastitis?

A

Usually an ascending infection via the teat r damaged skin around mammary glands eg trauma from puppy teeth, predisposed by poor hygiene, bacteria grow well in milky mammary tissue. Spectrum of severity rom acute/toxic to low grade and chronic. Hot painful glands with purulent material, abscess and sloughing in severe cases, dam depressed, pyrexic and anorexic, septic mastitis in very serious endotoxic shock, collapse and death are possible. Treat with broad spectrum antibiotics. Mastitis is usually caused by staphs, streps or E. coli. Analgesics ad anti inflammatories, iv fluids, warm compress, wound management, gentle lavage, debridement under GA, rest from puppies, cabergoline to stop lactation.