Reproduction Flashcards
What is Meiosis? The phases of meiosis?
Meiosis is the process of making haploid germ cells from diploid cells.
- Meiosis 1 - The reduction from diploid to haploid.
- Meiosis 2 - creation of 4 haploid cells
What special event happens during prophase 1 of meiosis 1?
Recombination. Homologous chromosomes come together to form the synaptonemal complex ( tetrad) and genes cross over at the chisma.
genes further apart are less linked and cross over at a higher probability.
Describe the stages of meiosis 1
Prophase 1- nuclear envelope breaks down, chromosomes condense, process of recombination.
Metaphase 1- homologous chromosomes line up alongside the metaphase plate
Anaphase 1 - the homologous chromosomes are pulled apart to opposite sides of the cell.
Telophase & Cytokenesis - nuclear envelope redevelops, chromosomes decondense, and diploid cell splits into 2 haploid cells.
Hemizygous
When you have one allele for a gene.
Are biological sex is determined by what pair of chromosomes?
23rd pair when shown of karyotype.
XY- males
XX- Females
What gene determines male development?
SRY gene which is located on the Y chromosome
What are the 2 functional groups of the male gonads?
Seminiferous tubules which produce sperm, they’re nourished by sertoli cells.
leydig interstital cells which secrete testosterone and other male androgens.
Role of Seminal vesicles, prostate glands, and bulbrothral glands of the male gonads.
- Seminal vesicles - create fructose to power sperm’s flagellum.
- Prostate gland- provides sperm a slight alkalinity so it can survive in acidic environment of the vagina.
- bulbrotheral gland - produce liquid lubricates and cleans out urethra.
What is the path sperm takes to exit the penis?
SEVE(N) UP
- Seminiferous tubules
- Epididymus
- vas deferens
- Ejaculatory ducts
- urethra
- penis
Describe the process of spermatogenesis
Diploid cells are spermatogonia –) undergo mitosis to become primary spermatocytes—) first meiotic division is to secondary spermatocytes—) second meiotic division is to spermatids which undergoes maturation to become spermatozoa.
What are the 4 parts of sperm?
- Head ( contains the acrosome) which serves to break through the female ovum.
- Midpiece - contains mitochondria which contains fructose to power the flagella via ATP.
- tail- used for movement
- endpiece- end part of the tail
What is the female reproductive system called?
There gonads are called the ovaries.
Once a month an egg is released from the ovaries how is this achieved?
cilia hairs brushes the egg form the peritoneal cavity into the fallopian tubes where it waits to get fertilized.
The cervix is below the uterus and is semen is deposited.
Describe the process of oogenesis
Produces female ovum.
- oogonium undergoes mitosis to become a primary ooctye ( arrested in prophase 1 until menstrual cycle)
- primary ooctye undergoes meiosis I to become secondary ooctye and the 1st polar body ( which is arrested in metaphase II until fertilization).
- secondary oocyte finishes. meiosis 2 to become ovum ( ovum = fertilized ooctye)
What protects the ooctye?
2 layers. 1st layer is the corona radiata and the second layer is the zona pellucida. This two layers are made of glycoproteins.
When we hit puberty which hormones are released to develop and maintain the reproductive system?
Gonadotropin- releasing hormone ( GnRH) is released from the hypothalamus and travels to the anterior pituitary where LH and FSH are released.
- In males LH acts on interstitial leydig cells which secretes testosterone and FSH which activates sertoli cells which aids in sperm maturation.
- testosterone is responsible for male characteristics like a deep voice ( has a negative feedback on hypothalamus and anterior pituitary)
- female ovaries released estrogen which is responsible for female characteristics like widening of the hips, development of breasts, etc.
Describe the menstrual cycle in females.
- Follicular phase- the endometrial lining is shed from the previous cycle). Estrogen and Progesterone levels fall has GnRH, FSH, LH levels increase causing the formation of ovarian follicles. They secrete estrogen which exerts a negative feedback on the hypothalamus and A. pituitary.
- Ovulation- Once estrogen reach certain levels it switches to positive feedback and increases release of hormones from hypothalamus and A. pituitary. The increase in LH in particular causes the release of the ooctye into peritoneal cavity.
- Luteal phase- the ruptured follicular cells come together to form corpus leuteum which secretes progesterone. This exerts a negative feedback on hypothalamus and A. pituitary so that another ooctye is not released.
- If pregnancy occurs the zygote divides into a blastocyst and implant into the uterine wall and secretes HCG which maintains the corpus leuteum ability to secrete progesterone until the third trimester in which the placenta can make progesterone on its on. If it doesn’t occur than corpus leuteum loses it’s ability to secrete progesterone and the lining decreases. The negative feedback is also disresupted and so high levels of hormoes results and the cycle starts over.
Menopause
When a women ages her ovaries become less sensitive to FSH and LH.
Estrogen and progesterone levels drop and FSH and LH levels rise due to the inability to exert negative feedback this causes high levels of both hormones in the blood.
Fertilization of the ovum by sperm
Sperm combines with ovum in the ampulla of the fallopian tube.
Acrosomal Apparatus
When sperm penetrates the corona radiata and the zona pellucida and forms the acrosomal apparatus and injects it’s pronucleus.
Cortical reaction
When the acrosomal apparatus forms it releases calcium ions which increase the metabolism of the zygote and to prevent sperm from further penetrating it.
Fraternal ( dizygotic ) twins v. Identical ( monozygotic) twins
Fraternal twins results from 2 different sperm penetrating two different ovum.
Identical twins results from splitting of the zygote. ** Identical twins can be identified by having identical placental structures**
Cleavage ( intermediate v. Determinate)
The division of embryonic stem cells of the zygote ( from there it’s morula and then blastula).
- Intermediate - cells can become any cell in the body.
- Determinate- cells become a specific type of cell.
Blastocyst
Results from division of zygote to morula and morula to blastocyst.
The blastocyst contains the blastocoel which is the fluid filled center and 2 different cell types.
Blastula implants into uterine wall to form the placenta.
Chorion
Contains the chorionic villi which penetrates the endometrial layer and creates interface between maternal and fetal blood.
Yolk sac
Sac that holds the fetus
Allantois
Allows fluid exchange between the yolk sac and embryo.
Amnion
Located outside of chorion creates amniotic fluid.
What connects the embryo to the placenta?
Umbilical cord
What is gastrulation?
The formation of the 3 germ layers from the blastocyst.
Describe the structures of the blastula ( blastocyst)
The archenteron is the center of the blastula and the opening is the blastopore. Ectoderm on the outside of blastula, endoderm is on the inside, and mesoderm in the middle.
What structures form from the following germ layers?
- Ectoderm
- Mesoderm
- Endoderm
- Ectoderm - forms more “ outside” structures like th epidermis, hair/skin/ nails. epithelia, and the nervous system.
- Mesoderm- more “ middle structures” like musculoskeletal system, circulatory system, excretory system, connective tissue, gonads.
- Endoderm - epithelial lining of respitory system, digestive system, and other organs.
Neurulation
The process of creating the nervous system once the 3 germ layers formed.
- The notochord contains neural folds which surrounds the neural groove. This creates the neural tube.
- The neural tube becomes the central nervous system while the the cells at the tip of the neural tube contains neural crest cells which turns into the peripheral nervous system.
Tetrogens
Substances that harm the development of the fetus.
Tetrogens can include: alcohol, some prescription drugs, viruses, environmental factors, diabetes, folic acid deficiency.
Cell specialization includes determination and differentiation. What are these?
- Determination- When the cell becomes set ( “ determined”) to a certain cell lineage. This happens when cells responds to morphegans. In order to responds to morphegans the cell must have competency.
- Differentiation is the selective transcription that leads to a specific cell.
What are stem cells? Describe the following stem cell classes.
- Totipotent
- Pluripotent
- Multipotent
- Unipotent
Stem cells are cells that can become other classes of cells.
- Totipotent - cell can differentiate into ANY type of cell in the body. Any of the 3 germ layers and placental cells.
- Pluripotent- cell can become any cell type of any of the 3 germ layers.
- Multipotent - cell can become any cell of one of the 3 germ layers.
- Unipotent- cell can become only one specific type of cell.
Cells that communicate to other cells are refered to as what. What are the recieving cells called?
Inducers are the cells that sends the signal while responders receive the signal.
- Reciprocal induction is when two cells induce differentiation in each other.
Autocrine
Paracrine
Juxtacrine
Endocrine
Autocrine- Signal that acts on the same cell that released the signal.
Paracrine- signal travels a short distance to reach responder. Signal travels short distance.
Juxtacrine - signal acts acts on adjacent cells
Endocrine - signals travel through bloodstream. Signal moves long distance.