Repro Toxicology Flashcards
1
Q
RX list
A
- Valproic Acid
- Thalidomide
- Diethylstilbestrol
- ACE-I (-pril)
2
Q
x-ray
A
- 5000-abortion
- 50-microcephaly
- 5-counseling threshold (
- 0.05-no effect
3
Q
Toxic MOAs
A
- Mutagenesis
- Carcinogenesis
- Endo activity
4
Q
FDA Preg Codes
A
*same level of birth defects can get safer code if treating worse illness
5
Q
Valproic Acid
A
Spina Bifida risk
- Migraine= C/I, b/c other treatments available
- cogn impairment
- autism
6
Q
New labeling
A
- Risk summary = summary in plain english
- Clinical considerations = adverse reaction, labor
- Data = Mostly animal studies when marketed
7
Q
Animal studies:
What to know?
A
- species
- dose range = plasma metabolites
- maternal toxicity
- fetal effects = number, viability, weight, malformations
8
Q
Thalidomide
A
- focomilia = middle part of limb doesn’t grow
* selectively toxic to embryo, less mother
9
Q
ACE-I
A
- brain/skull malformation
- damage to renin system = absence of amniotic fluid poorly prefused, necrosis of skull, if born- renal problems
- Missed because Renin system comes in 2nd trimester
10
Q
Deithylsteilbestrol
A
- Clear cell carcinoma,
- vag malformations,
- T shaped uterus
- environment can easily cause cancer
