Repro Drugs

Question 1

Progesterone antagonist

Answer 1

Mifepristone

MOA: antagonist

Question 2

5-alpha Reductase Inhibitors (general -2)

Answer 2

Finasteride

Dutasteride

Question 3

5-alpha Reductase Inhibitors (Finasteride)

Answer 3

MOA: antagonist
TU: BPH, male pattern baldness

Question 4

Progesterone partial agonist

Answer 4

Ulipristal

MOA: partial agonist
TU: emergency contraception

Question 5

Prolactin secretion inhibitors

Answer 5

Bromocriptine
Cabergoline

MOA: D2 agonist
TU: prolactinoma

Question 6

Oxytocin

Answer 6

Testosterone
Testosterone Esters
Dihydrotestosterone
Methyltestosterone

MOA: agonist
TU: androgen replacement therapy, anabolic effects

Question 7

Androgen Receptor Antagonists

Answer 7

Flutamide

MOA: antagonist
TU: prostate cancer

Question 8

5-alpha reductase Inhibitors (Dutasteride)

Answer 8

MOA: antagonist
TU: BPH

Question 9

Smooth muscle relaxants

Answer 9

Alfusozin
Tamsulosin
Silodosin

MOA: α1-adrenergic receptor antagonist
TU: BPH

Question 10

FSH (general-3)

Answer 10

human menopausal gonadotropins

Urofilotropin

Follitropin alpha and beta

Question 11

FSH (human menopausal gonadotropins)

Answer 11

MOA: human FSH and LH

Question 12

FSH (urofollitropin)

Answer 12

MOA: purified human FSH

Question 13

FSH (follitropin alpha and beta)

Answer 13

MOA: recombinant FSH

Question 14

LH (general-2)

Answer 14

lutropin alpha

choriogonadotropin alpha

Question 15

LH (lutropin alpha)

Answer 15

MOA: recombinant LH
TU: diagnostics, stimulate ovulation, pregnancy kits

Question 16

LH (choriogonadotropin alpha)

Answer 16

MOA: recombinant hCG
TU: diagnostics, stimulate ovulation, pregnancy kits, male infertility

Question 17

Estrogen Drugs (broad Natural & Synthetic)

Answer 17

Natural:
17-Beta Estradiol
Conjugated estrogens
Phytoestrogens

Synthetic:
Ethinyl estradiol
Diethylstilbestrol

*all agonist

Question 18

Estrogen Drugs (17-Beta Estradiol)

Answer 18

MOA: agonist

*natural

Question 19

Estrogen Drugs (Conjugated estrogens & Phytoestrogens)

Answer 19

MOA: agonist
TU: HRT
*natural

Question 20

Estrogen Drugs (Ethinyl estradiol)

Answer 20

MOA: agonist

*synthetic

Question 21

Estrogen Drugs (Diethylstilbestrol)

Answer 21

MOA: agonist
TU: no longer used: causes vaginal cancer in female offspring
*synthetic

Question 22

Selective Estrogen Receptor Modulators (SERM) - (name the drugs)

Answer 22

1) Tamoxifen
2) Tomerifene
3) Raloxifene

*all partial agonist

Question 23

Selective Estrogen Receptor Modulators (SERM) - (Tamoxifen)

Answer 23

MOA: partial agonist
TU: ER + breast cancer

Question 24

Selective Estrogen Receptor Modulators (SERM) - (Tomeifene)

Answer 24

MOA: partial agonist
TU: breast cancer

Question 25

Selective Estrogen Receptor Modulators (SERM) - (Raloxifene)

Answer 25

MOA: partial agonist TU: osteoporosis, decrease risk of breast cancer

Question 26

Estrogen Antagonists (name the drugs)

Answer 26

1) Clomiphene 2) Fluvestrant *all antagonist

Question 27

Estrogen Antagonists (Clomiphene)

Answer 27

MOA: antagonist TU: induce ovulation

Question 28

Estrogen Antagonists (Fluvestrant)

Answer 28

MOA: antagonist TU: breast cancer

Question 29

Estrogen synthesis inhibitors (name the drugs)

Answer 29

1) Formestane 2) Exemestane 3) Anastrozole 4) Letrozole *all use for breast cancer

Question 30

Estrogen synthesis inhibitors (Formestane & Exemestane)

Answer 30

MOA: substrate suicide inhibitor TU: breast cancer

Question 31

Estrogen synthesis inhibitors (Anastrozole & Letrozole)

Answer 31

MOA: reversible inhibitor TU: breast cancer

Question 32

Progestins (name all the drugs)

Answer 32

``` Medroxyprogesterone Norethindrone Norethynodrel Ethynodiol diacetate Norgestimate Norgestrel Desogestrel Drospirenone ``` MOA: all agonist

Question 33

Phosphodiesterase 5 (PDE5) Inhibitors (name the drugs, MOA, and TU)

Answer 33

1. Sildenafil (Viagra®) 2. Vardenafil (Levitra®) 3. Tadalafil (Cialis®) 4. Avanafil (Stendra®) MOA: all increases cGMP TU: Erectile dysfunction

Question 34

Gonadotropins (name the drugs)

Answer 34

1. Gonadorelin 2. Leuprolide 3. Goserelin 4. Histrelin 5. Naferelin 6. Triptorelin 7. Ganirelix 8. Cetrorelix 9. Degarelix

Question 35

Gonadotropins (Gonadorelin)

Answer 35

MOA: hGnRH acetate salt TU: infertility, suppression of LH & FSH release, endometriosis, uterine leimyomata, prostate cancer, precocious puberty

Question 36

Gonadotropins (Leuprolide)

Answer 36

MOA: hGnRH analog TU:Endometriosis, uterine fibroids, prostate cancer, central precocious puberty

Question 37

Gonadotropins (Goserelin)

Answer 37

MOA: hGnRH analog TU: Endometriosis, prostate and breast cancer

Question 38

Gonadotropins (Histrelin)

Answer 38

MOA: hGnRH analog TU: Prostate cancer, Central precocious puberty

Question 39

Gonadotropins (Naferelin)

Answer 39

MOA: hGnRH analog TU: Central precocious puberty

Question 40

Gonadotropins (Triptorelin)

Answer 40

MOA: hGnRH analog TU: Prostate cancer

Question 41

Gonadotropins (Ganirelix)

Answer 41

MOA: GnRH antagonist TU: ovarian hyperstimulation

Question 42

Gonadotropins (Cetrorelix)

Answer 42

MOA: GnRH antagonist TU: ovarian hyperstimulation

Question 43

Gonadotropins (Degarelix)

Answer 43

MOA: GnRH antagonist TU: prostate cancer

Question 44

What are the 5 hGnRH analog drugs?

Answer 44

``` Leuprolide Goserelin Histrelin Naferelin Triptorelin ```

Question 45

What are the 3 GnRH antagonist drugs?

Answer 45

Ganirelix Cetrorelix Degarelix