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Pharm II > Repro Drugs > Flashcards

Repro Drugs Flashcards

1
Q

Progesterone antagonist

A

Mifepristone

MOA: antagonist

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2
Q

5-alpha Reductase Inhibitors (general -2)

A

Finasteride

Dutasteride

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3
Q

5-alpha Reductase Inhibitors (Finasteride)

A

MOA: antagonist
TU: BPH, male pattern baldness

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4
Q

Progesterone partial agonist

A

Ulipristal

MOA: partial agonist
TU: emergency contraception

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5
Q

Prolactin secretion inhibitors

A

Bromocriptine
Cabergoline

MOA: D2 agonist
TU: prolactinoma

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6
Q

Oxytocin

A

Testosterone
Testosterone Esters
Dihydrotestosterone
Methyltestosterone

MOA: agonist
TU: androgen replacement therapy, anabolic effects

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7
Q

Androgen Receptor Antagonists

A

Flutamide

MOA: antagonist
TU: prostate cancer

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8
Q

5-alpha reductase Inhibitors (Dutasteride)

A

MOA: antagonist
TU: BPH

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9
Q

Smooth muscle relaxants

A

Alfusozin
Tamsulosin
Silodosin

MOA: α1-adrenergic receptor antagonist
TU: BPH

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10
Q

FSH (general-3)

A

human menopausal gonadotropins

Urofilotropin

Follitropin alpha and beta

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11
Q

FSH (human menopausal gonadotropins)

A

MOA: human FSH and LH

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12
Q

FSH (urofollitropin)

A

MOA: purified human FSH

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13
Q

FSH (follitropin alpha and beta)

A

MOA: recombinant FSH

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14
Q

LH (general-2)

A

lutropin alpha

choriogonadotropin alpha

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15
Q

LH (lutropin alpha)

A

MOA: recombinant LH
TU: diagnostics, stimulate ovulation, pregnancy kits

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16
Q

LH (choriogonadotropin alpha)

A

MOA: recombinant hCG
TU: diagnostics, stimulate ovulation, pregnancy kits, male infertility

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17
Q

Estrogen Drugs (broad Natural & Synthetic)

A

Natural:
17-Beta Estradiol
Conjugated estrogens
Phytoestrogens

Synthetic:
Ethinyl estradiol
Diethylstilbestrol

*all agonist

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18
Q

Estrogen Drugs (17-Beta Estradiol)

A

MOA: agonist

*natural

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19
Q

Estrogen Drugs (Conjugated estrogens & Phytoestrogens)

A

MOA: agonist
TU: HRT
*natural

20
Q

Estrogen Drugs (Ethinyl estradiol)

A

MOA: agonist

*synthetic

21
Q

Estrogen Drugs (Diethylstilbestrol)

A

MOA: agonist
TU: no longer used: causes vaginal cancer in female offspring
*synthetic

22
Q

Selective Estrogen Receptor Modulators (SERM) - (name the drugs)

A

1) Tamoxifen
2) Tomerifene
3) Raloxifene

*all partial agonist

23
Q

Selective Estrogen Receptor Modulators (SERM) - (Tamoxifen)

A

MOA: partial agonist
TU: ER + breast cancer

24
Q

Selective Estrogen Receptor Modulators (SERM) - (Tomeifene)

A

MOA: partial agonist
TU: breast cancer

25
Q

Selective Estrogen Receptor Modulators (SERM) - (Raloxifene)

A

MOA: partial agonist
TU: osteoporosis, decrease risk of breast cancer

26
Q

Estrogen Antagonists (name the drugs)

A

1) Clomiphene
2) Fluvestrant

*all antagonist

27
Q

Estrogen Antagonists (Clomiphene)

A

MOA: antagonist
TU: induce ovulation

28
Q

Estrogen Antagonists (Fluvestrant)

A

MOA: antagonist
TU: breast cancer

29
Q

Estrogen synthesis inhibitors (name the drugs)

A

1) Formestane
2) Exemestane
3) Anastrozole
4) Letrozole

*all use for breast cancer

30
Q

Estrogen synthesis inhibitors (Formestane & Exemestane)

A

MOA: substrate suicide inhibitor
TU: breast cancer

31
Q

Estrogen synthesis inhibitors (Anastrozole & Letrozole)

A

MOA: reversible inhibitor
TU: breast cancer

32
Q

Progestins (name all the drugs)

A 
Medroxyprogesterone Norethindrone 
Norethynodrel 
Ethynodiol diacetate 
Norgestimate 
Norgestrel 
Desogestrel 
Drospirenone

MOA: all agonist

33
Q

Phosphodiesterase 5 (PDE5) Inhibitors (name the drugs, MOA, and TU)

A
  1. Sildenafil (Viagra®)
  2. Vardenafil (Levitra®)
  3. Tadalafil (Cialis®)
  4. Avanafil (Stendra®)

MOA: all increases cGMP
TU: Erectile dysfunction

34
Q

Gonadotropins (name the drugs)

A
  1. Gonadorelin
  2. Leuprolide
  3. Goserelin
  4. Histrelin
  5. Naferelin
  6. Triptorelin
  7. Ganirelix
  8. Cetrorelix
  9. Degarelix
35
Q

Gonadotropins (Gonadorelin)

A

MOA: hGnRH acetate salt
TU: infertility, suppression of LH & FSH release, endometriosis, uterine leimyomata, prostate cancer, precocious puberty

36
Q

Gonadotropins (Leuprolide)

A

MOA: hGnRH analog
TU:Endometriosis, uterine fibroids, prostate cancer, central precocious puberty

37
Q

Gonadotropins (Goserelin)

A

MOA: hGnRH analog
TU: Endometriosis, prostate and breast cancer

38
Q

Gonadotropins (Histrelin)

A

MOA: hGnRH analog
TU: Prostate cancer, Central precocious puberty

39
Q

Gonadotropins (Naferelin)

A

MOA: hGnRH analog
TU: Central precocious puberty

40
Q

Gonadotropins (Triptorelin)

A

MOA: hGnRH analog
TU: Prostate cancer

41
Q

Gonadotropins (Ganirelix)

A

MOA: GnRH antagonist
TU: ovarian hyperstimulation

42
Q

Gonadotropins (Cetrorelix)

A

MOA: GnRH antagonist
TU: ovarian hyperstimulation

43
Q

Gonadotropins (Degarelix)

A

MOA: GnRH antagonist
TU: prostate cancer

44
Q

What are the 5 hGnRH analog drugs?

A 
Leuprolide
Goserelin 
Histrelin
Naferelin 
Triptorelin
45
Q

What are the 3 GnRH antagonist drugs?

A

Ganirelix
Cetrorelix
Degarelix

Pharm II (4 decks)

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