Repressors Flashcards
1
Q
Cro repressor
A
Lytic growth
Transcribe right
Blocks Lambda
3 helices in HTH
3 beta strands Dimerize
1 helix binds DNA Major groove
dimer binds two major grooves on same side
2
Q
Lambda repressor
A
Lysogenic growth
Transcribe Left
Blocks cro
5 helices
3 are HTH binding DNA
2 are dimerizing
helices bind to major groove
3
Q
Trp repressor
A
Core domain: 1,2 dimerize
head domain: 4,5,6 bind dna (5 binds to DNA)
3 connects the domains
conformational change
Binding of ligand activates repressor
4
Q
Lac repressor
A
Hairpin
tetramer
conformational change
binding of ligand deactivates repressor
5 helices