Repetitorium

Question 1

Neutralizing antibodies action

Answer 1

target viral glycoproteins > block host cell entry of viruses

Question 2

Enveloped viral entry into cells - block?

Answer 2

ab can bind viral GP and block virus entry

Glycoproteins of enveloped viruses mediate membrane fusion

Question 3

HIV maturation and inhibition?

Answer 3

HIV maturation is due to the activity of the viral protease. The HIV protease is a target for antiviral intervention.

Question 4

Renin-angiotensin sytem

Answer 4

Controls blood pressure. Can play a role in virus induced lung injury.

Question 5

SARS-CoV - resevoir, receptor expression

Answer 5

Uses bats as natural reservoir. Alters ACE2 expression in the lung and thereby promotes lung disease.

Question 6

TMPRSS2

Answer 6

Primes influenza A hemagglutinin for membrane fusion.

Is required for influenza A virus spread and pathogenesis in mice.

Question 7

Exchange of genetic segments between inluenza A virus (reassortment) is intimately linked with..

Answer 7

antigenic shift, pandemic influenza

Question 8

Interferon system

Answer 8

JAK/STAT signaling is required for ISG expression.

Antiviral effectors of the interferon system block HIV infection of macaque cells.

Question 9

HIV-2

Answer 9

HIV-2 is attenuated as compared to HIV-1. HIV-2 is endemic in Western Africa.

Question 10

Rabies and Ebola infection route,

Answer 10

Rabies: direct transmission by animal bites
Ebola: direct transmission by bodily fluids

Question 11

Herpesviruses

Answer 11

Estabolish lifelong latency.
Are medically important in the context of immunosuppression.
Cannot replicate wihout expression of IE gene products.