renal transplant

Question 1

What is the initial change in serum erythropoietin levels observed post-renal transplant, and how do these levels change over time?

Answer 1

Post-renal transplant, there is an initial increase in serum erythropoietin levels. These levels subsequently fall back to a baseline level over time.

Question 2

Describe the subsequent hematological changes that follow the initial increase in serum erythropoietin post-transplant.

Answer 2

Following the initial increase in serum erythropoietin, there is a reticulocytosis (increase in reticulocyte count) and a rise in hematocrit.

Question 3

What are the potential causes of post-transplant erythrocytosis

Answer 3

Potential causes of post-transplant erythrocytosis include:
oversecretion of erythropoietin by the native kidneys, the transplanted kidney, or the liver.

Some patients may have low erythropoietin levels

and other factors like IGF-1 might also play a role

Question 4

What percentage of transplant patients are affected by post-transplant erythrocytosis, and within what timeframe is it most likely to occur?

Answer 4

What percentage of transplant patients are affected by post-transplant erythrocytosis, and within what timeframe is it most likely to occur?

Question 5

Which groups of transplant patients are most at risk for developing post-transplant erythrocytosis?

Answer 5

The groups most at risk include hypertensive males, those with autosomal dominant polycystic kidney disease (ADPKD), and patients who have received a simultaneous pancreas and kidney transplant.

Question 6

complications of untreated post-transplant erythrocytosis?

Answer 6

increased incidence of vascular and thromboembolic disorders or excessive bleeding.

Question 7

How might the presence of native kidneys in transplant patients influence the risk of developing erythrocytosis?

Answer 7

the native kidneys may continue to secrete erythropoietin, contributing to elevated erythrocyte levels.