Renal Scenario Flashcards
What are the main structures of the renal system?
2 kidneys 2 ureters Bladder 2 sphincter muscles Urethra Nerves
What is the function of the kidneys?
They maintain homeostasis:
Excrete waste products and drugs
Maintain fluid balance
Blood filtration
Hormone production for BP regulation
Production of RBC’s(erythropoietin production, controls RBC production).
Nephron is the ‘functional unit’ of the kidneys
What are nephrons + what is their function?
Functional unit of the kidneys, removing urea from the blood, urine is formed as it filters through the nephrons down the renal tubules.
They feature tubules, closed at one end, joining collecting duct at the other end.
Closed end is indented, forming glomerular capsule (almost completely enclose a network of arterial capillaries called the glomerulus).
There are 1 million nephrons in one kidney.
What does urine consist of?
95% water
Urea
Various other chemicals (sodium, chloride, potassium)
What is the function of the ureters?
They carry urine from kidneys to bladder.
Muscles in ureter walls continually tighten and relax forcing urine downwards away from kidneys.
Around every 10-15 seconds, small amounts of urine are emptied into bladder from ureters.
What is the function of the bladder?
Storage and emptying of urine.
Holds around 300-400mls during the day, roughly 800mls at night.
Sensation to urine increase as bladder fills, brain sends signals to nerves in the bladder to contract to expel urine whilst the brain sends signals to the nerves in the sphincters to relax, allowing the flow of urine through the urethra.
What is the function of the sphincters?
Circular muscles called sphincters help keep urine from leaking. The sphincter muscles close tightly like a rubber band around the opening of the bladder into the urethra.
Damage to area of brain controlling sphincter muscles or damage to pelvic floor muscles can cause incontinence problems.
How do the kidneys maintain fluid balance?
They can adjust urine concentration to reflect the body’s water needs.
-conserving water if dehydrated, expelling water in dilute urine if in excess.
Antidiuretic hormone(ADH) stimulates water reabsorbtion by stimulating insertion of "water channels" or aquaporins into the membranes of kidney tubules. These channels transport solute-free water through tubular cells and back into blood, leading to a decrease in plasma osmolarity and an increase osmolarity of urine. ADH is released by the pituitary gland when hypothalamus sends signals.
What role do the kidneys play in RBC formation?
The kidneys produce erythropoietin, a hormone that stimulates RBC formation.
It is produced and expelled into the blood stream if blood oxygen levels are low.
It travels to the bone marrow where it stimulates stem cells to become RBC’s.
What role do the kidneys play in acid base balance?
Acid base balance is the balance of acidic and basic compounds in the blood.
the kidneys maintain ABB by reabsorbing bicarbonate from urine and excreting hydrogen ions into urine.
What role do the kidneys play in renin-angiotensin mechanisms?
The renin-angiotensin-aldosterone system (RAAS) is a signaling pathway responsible for regulating the body’s blood pressure. Stimulated by low blood pressure or certain nerve impulses (e.g. in stressful situations), the kidneys release an enzyme called renin.
What are the signs and symptoms of kidney disease?
Itching Muscle cramps Nausea and vomiting Decreased appetite Oedema in feet and ankles Too much urine or not enough urine SOB Trouble sleeping
What are the signs and symptoms of kidney failure?
Itching Muscle cramps Nausea and vomiting Decreased appetite Oedema in feet and ankles Polyuria or oliguria SOB Trouble sleeping (Same as CKD)
What are the causes of kidney failure?
Diabetes
Hypertension
Autoimmune diseases, such as lupus and IgA nephropathy
Genetic diseases such as polycystic kidney disease
Nephrotic syndrome
Urinary tract problems
What is kidney failure?
Also known as End Stage Renal Disease, it is the last stage of CKD in which the kidneys are no longer able to function without dialysis or a kidney transplant.
What are the 5 stages of renal failure?
Stage 1 with normal or high GFR (GFR > 90 mL/min)
Stage 2 Mild CKD (GFR = 60-89 mL/min)
Stage 3A Moderate CKD (GFR = 45-59 mL/min)
Stage 3B Moderate CKD (GFR = 30-44 mL/min
Stage 4 Severe CKD (GFR = 15-29 mL/min)
Stage 5 End Stage CKD (GFR <15 mL/min)
What is GFR?
Glomerular filtration rate (GFR) measures kidney function.
It measures how effectively the kidneys clean to blood by measuring creatinine levels.
As kidney function declines, creatinine levels increase.
What is CKD?
Chronic kidney disease (CKD) occurs when kidneys are no longer able to clean toxins and waste product from the blood and perform their functions to full capacity.