Renal Regulation of Water And Acid Base Balance Flashcards
Total fluid volume
~60% body weight
Unregulated water loss
Sweat
Feces
Vomit
Water evaporation from respiratory lining and skin
Regulated water loss
Renal regulation
High water intake
Increased ECF volume
Decreased sodium concentration
Decreased osmolarity
Hypoosmotic urine production
Low water intake
Decreased ECF volume
Increased sodium concentration
Increased osmolarity
Hyperosmotic urine production
Vasopressin effect in urea recycling
Increased number of UT-A1 and UT-A3
Vasopressin function
Promote water reabsorption from collecting duct
Central diabetes insipidus cause
Decreased/negligent production and release of ADH
Central diabetes insipidus clinical features
Polyuria
Polydipsia
Central diabetes insipidus treatment
External ADH
Syndrome of inappropriate ADH secretion cause
Increased production of release of ADH
Syndrome of inappropriate ADH secretion clinical features
Hyperosmolar urine
Hypervolemia
Hyponatremia
Syndrome of inappropriate ADH secretion treatment
Non-peptide inhibitor of ADH receptor (conivaptan and tolvaptan)
Fluid restriction
Nephrogenic diabetes insipidus cause
Less/mutant AQP2
Mutant V2 receptor
Nephrogenic diabetes insipidus clinical features
Polyuria
Polydipsia
